Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLE3
  • Mouse genes Tle3
  • Rat genes Tle3
  • Zfish genes tle3a,tle3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tle3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TLE3	IPI	UniProtKB:Q9BQA5	Human	PMID:17577209
Molecular Function	GO:0005515	protein binding	TLE3	IPI	UniProtKB:P98170	Human	PMID:22304967
Molecular Function	GO:0005515	protein binding	TLE3	IPI	UniProtKB:Q9NQB0	Human	PMID:22304967
Molecular Function	GO:0005515	protein binding	TLE3	IPI	UniProtKB:O95935	Human	PMID:26235987
Molecular Function	GO:0005515	protein binding	Tle3	IPI	PR:P42586	Mouse	PMID:17202186
Molecular Function	GO:0005515	protein binding	Tle3	IPI	UniProtKB:P32182	Rat	PMID:10748198|RGD:8553421
Molecular Function	GO:0005515	protein binding	tle3a	IPI	UniProtKB:Q2WG80	Zfish	PMID:16326386|ZFIN:ZDB-PUB-051214-10
Molecular Function	GO:0005515	protein binding	tle3a	IPI	ZFIN:ZDB-GENE-980605-30	Zfish	PMID:25371059
Molecular Function	GO:0005515	protein binding	tle3a	IPI	ZFIN:ZDB-GENE-001206-2	Zfish	PMID:25371059
Cellular Component	GO:1990907	beta-catenin-TCF complex	TLE3	IDA		Human	PMID:28296634
Cellular Component	GO:0005654	nucleoplasm	TLE3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Tle3	IDA		Rat	PMID:10748198|RGD:8553421
Biological Process	GO:0030099	myeloid cell differentiation	tle3b	IMP	ZFIN:ZDB-MRPHLNO-081001-1	Zfish	PMID:18258796
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Tle3	IMP		Mouse	MGI:MGI:5495578|PMID:23473036
Biological Process	GO:0006355	regulation of DNA-templated transcription	Tle3	IDA		Rat	PMID:10800926|RGD:634434
Biological Process	GO:1900052	regulation of retinoic acid biosynthetic process	tle3a	IGI	ZFIN:ZDB-GENO-090916-1,ZFIN:ZDB-MRPHLNO-101021-7	Zfish	PMID:20850014
Biological Process	GO:0061056	sclerotome development	tle3a	IMP	ZFIN:ZDB-MRPHLNO-170810-2	Zfish	PMID:28630873

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern