Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLE4
  • Mouse genes Tle4
  • Rat genes Tle4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tle4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Tle4	IDA		Mouse	PMID:16002402
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Tle4	IPI	UniProtKB:P0CL69	Mouse	MGI:MGI:4940410|PMID:21317240
Molecular Function	GO:0005515	protein binding	TLE4	IPI	UniProtKB:Q02962	Human	PMID:24676634
Molecular Function	GO:0005515	protein binding	Tle4	IPI	UniProtKB:P80206	Mouse	MGI:MGI:6245330|PMID:17060451
Molecular Function	GO:0005515	protein binding	Tle4	IPI	PR:P24610	Mouse	PMID:15729346
Molecular Function	GO:0005515	protein binding	Tle4	IPI	PR:P80205	Mouse	PMID:15105370
Molecular Function	GO:0005515	protein binding	Tle4	IPI	PR:P25425	Mouse	PMID:16002402
Molecular Function	GO:0005515	protein binding	Tle4	IPI	PR:P27782	Mouse	PMID:15729346
Molecular Function	GO:0005515	protein binding	Tle4	IPI	PR:Q62233	Mouse	PMID:12050133
Molecular Function	GO:0005515	protein binding	Tle4	IPI	PR:P80206	Mouse	PMID:15105370
Molecular Function	GO:0005515	protein binding	Tle4	IPI	PR:P13297	Mouse	PMID:16002402
Molecular Function	GO:0005515	protein binding	Tle4	IPI	PR:Q9QZ28	Mouse	PMID:12050133
Molecular Function	GO:0003714	transcription corepressor activity	Tle4	IDA		Mouse	MGI:MGI:4940410|PMID:21317240
Molecular Function	GO:0003714	transcription corepressor activity	Tle4	IDA		Mouse	PMID:15105370
Molecular Function	GO:0003714	transcription corepressor activity	Tle4	IDA		Mouse	PMID:12050133
Molecular Function	GO:0003714	transcription corepressor activity	Tle4	IGI	MGI:MGI:101898	Mouse	PMID:16002402
Molecular Function	GO:0003714	transcription corepressor activity	Tle4	IGI	MGI:MGI:97168	Mouse	PMID:16002402
Molecular Function	GO:0003714	transcription corepressor activity	Tle4	IGI	MGI:MGI:97487	Mouse	PMID:15729346
Molecular Function	GO:0003714	transcription corepressor activity	Tle4	IGI	MGI:MGI:96770	Mouse	PMID:15729346
Molecular Function	GO:0003714	transcription corepressor activity	Tle4	IGI	MGI:MGI:88276	Mouse	PMID:15729346
Cellular Component	GO:1990907	beta-catenin-TCF complex	TLE4	IDA		Human	PMID:28296634
Cellular Component	GO:0005654	nucleoplasm	TLE4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TLE4	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	Tle4	IDA		Mouse	MGI:MGI:6245330|PMID:17060451
Cellular Component	GO:0005634	nucleus	Tle4	IDA		Rat	PMID:8245004|RGD:69851
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Tle4	IEP		Mouse	PMID:20439489
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Tle4	IDA		Mouse	MGI:MGI:4940410|PMID:21317240
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Tle4	IDA		Mouse	PMID:12050133
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tle4	IDA		Mouse	PMID:16002402
Biological Process	GO:0016055	Wnt signaling pathway	Tle4	IDA		Mouse	PMID:15105370

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern