Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLK2
  • Mouse genes Tlk2
  • Rat genes Tlk2
  • Zfish genes tlk2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tlk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	TLK2	IDA		Human	PMID:12660173
Molecular Function	GO:0042802	identical protein binding	TLK2	IPI	UniProtKB:Q86UE8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TLK2	IPI	UniProtKB:Q15306	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TLK2	IPI	UniProtKB:Q92985	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TLK2	IPI	UniProtKB:P26367	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TLK2	IPI	UniProtKB:Q02548	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TLK2	IPI	UniProtKB:Q7KZS0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TLK2	IPI	UniProtKB:Q8NHQ1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TLK2	IPI	UniProtKB:Q96IK5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TLK2	IPI	UniProtKB:Q96NE9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TLK2	IPI	UniProtKB:Q9NPF5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Tlk2	IPI	UniProtKB:Q924N4	Mouse	MGI:MGI:6221361|PMID:27782176
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TLK2	IDA		Human	PMID:12660173
Cellular Component	GO:0005882	intermediate filament	TLK2	IDA		Human	PMID:10455159
Cellular Component	GO:0005882	intermediate filament	Tlk2	IDA		Mouse	MGI:MGI:1343639|PMID:10455159
Cellular Component	GO:0005634	nucleus	TLK2	IDA		Human	PMID:10455159
Cellular Component	GO:0005634	nucleus	TLK2	IDA		Human	PMID:9427565
Cellular Component	GO:0005634	nucleus	Tlk2	IDA		Mouse	MGI:MGI:1343639|PMID:10455159
Cellular Component	GO:0048471	perinuclear region of cytoplasm	TLK2	IDA		Human	PMID:10455159
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Tlk2	IDA		Mouse	MGI:MGI:1343639|PMID:10455159
Biological Process	GO:0071480	cellular response to gamma radiation	TLK2	IDA		Human	PMID:12660173
Biological Process	GO:0007059	chromosome segregation	TLK2	IMP		Human	PMID:20705056
Biological Process	GO:0006974	DNA damage response	TLK2	IDA		Human	PMID:12660173
Biological Process	GO:0035556	intracellular signal transduction	TLK2	IDA		Human	PMID:12660173
Biological Process	GO:0051179	localization	TLK2	EXP		Human	PMID:29955062
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	TLK2	IMP		Human	PMID:20016786
Biological Process	GO:0018105	peptidyl-serine phosphorylation	TLK2	IDA		Human	PMID:20016786
Biological Process	GO:0006468	protein phosphorylation	TLK2	IDA		Human	PMID:12660173
Biological Process	GO:1902275	regulation of chromatin organization	TLK2	IDA		Human	PMID:12660173

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern