Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tlr3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TLR3
- Mouse genes Tlr3
- Rat genes Tlr3
- Zfish genes tlr3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tlr3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	TLR3	IDA		Human	PMID:16111635
Molecular Function	GO:0003725	double-stranded RNA binding	Tlr3	IDA		Rat	PMID:16973131\|RGD:1643119
Molecular Function	GO:0042802	identical protein binding	TLR3	IPI	UniProtKB:O15455	Human	PMID:18172197
Molecular Function	GO:0042802	identical protein binding	TLR3	IPI	UniProtKB:O15455	Human	PMID:23155421
Molecular Function	GO:0042802	identical protein binding	TLR3	IPI	UniProtKB:O15455	Human	PMID:25217833
Molecular Function	GO:0038187	pattern recognition receptor activity	TLR3	IDA		Human	PMID:16720699
Molecular Function	GO:0005515	protein binding	TLR3	IPI	UniProtKB:P27986	Human	PMID:16858407
Molecular Function	GO:0005515	protein binding	TLR3	IPI	UniProtKB:Q8IUC6	Human	PMID:25736436
Molecular Function	GO:0005515	protein binding	TLR3	IPI	UniProtKB:Q8IWB7	Human	PMID:25736436
Molecular Function	GO:0005515	protein binding	TLR3	IPI	UniProtKB:Q9H1C4	Human	PMID:33432245
Molecular Function	GO:0005515	protein binding	Tlr3	IPI	UniProtKB:Q8VCW4	Mouse	MGI:MGI:6695691\|PMID:33432245
Molecular Function	GO:0005515	protein binding	Tlr3	IPI	UniProtKB:E9Q4P1\|UniProtKB:Q80UF7	Mouse	MGI:MGI:5688815\|PMID:25736436
Molecular Function	GO:0005515	protein binding	Tlr3	IPI	UniProtKB:Q8VCW4	Mouse	MGI:MGI:4457250\|PMID:17452530
Molecular Function	GO:0005515	protein binding	tlr3	IPI	UniProtKB:Q1LUQ2	Zfish	PMID:17372010
Molecular Function	GO:0004888	transmembrane signaling receptor activity	Tlr3	IDA		Mouse	PMID:27830702
Cellular Component	GO:0009986	cell surface	Tlr3	IDA		Rat	PMID:20500834\|RGD:5128706
Cellular Component	GO:0005737	cytoplasm	TLR3	IDA		Human	PMID:19740627
Cellular Component	GO:0005769	early endosome	TLR3	IDA		Human	PMID:17982077
Cellular Component	GO:0005765	lysosomal membrane	TLR3	HDA		Human	PMID:17897319
Cellular Component	GO:0005886	plasma membrane	Tlr3	IDA		Mouse	PMID:27830702
Biological Process	GO:0071360	cellular response to exogenous dsRNA	Tlr3	IMP		Rat	PMID:15920723\|RGD:2301737
Biological Process	GO:0071360	cellular response to exogenous dsRNA	Tlr3	IEP		Rat	PMID:20937230\|RGD:5128701
Biological Process	GO:0035458	cellular response to interferon-beta	Tlr3	IEP		Rat	PMID:15661832\|RGD:5128798
Biological Process	GO:0071260	cellular response to mechanical stimulus	TLR3	IEP		Human	PMID:19593445
Biological Process	GO:0071346	cellular response to type II interferon	Tlr3	IEP		Rat	PMID:16638093\|RGD:5128794
Biological Process	GO:0098586	cellular response to virus	Tlr3	IMP		Mouse	PMID:18802055
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Tlr3	IEP		Rat	PMID:15661832\|RGD:5128798
Biological Process	GO:0032602	chemokine production	Tlr3	IMP	MGI:MGI:3690535	Mouse	PMID:12855817
Biological Process	GO:0006952	defense response	Tlr3	IMP	MGI:MGI:2653138	Mouse	PMID:11607032
Biological Process	GO:0051607	defense response to virus	TLR3	IEP		Human	PMID:32634389
Biological Process	GO:0051607	defense response to virus	Tlr3	IGI	MGI:MGI:2429859	Mouse	PMID:18250457
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	TLR3	IDA		Human	PMID:21737330
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Tlr3	IGI	MGI:MGI:1346877	Mouse	PMID:16260493
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Tlr3	IMP	MGI:MGI:3690535	Mouse	PMID:12855817
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Tlr3	IDA		Mouse	PMID:16260493
Biological Process	GO:0007252	I-kappaB phosphorylation	TLR3	IDA		Human	PMID:19740627
Biological Process	GO:0090594	inflammatory response to wounding	Tlr3	IDA		Mouse	PMID:27830702
Biological Process	GO:0032635	interleukin-6 production	Tlr3	IDA		Mouse	PMID:18261938
Biological Process	GO:0007254	JNK cascade	Tlr3	IMP		Mouse	PMID:18802055
Biological Process	GO:0007254	JNK cascade	Tlr3	IDA		Mouse	PMID:16260493
Biological Process	GO:0010934	macrophage cytokine production	Tlr3	IMP	MGI:MGI:3690535	Mouse	PMID:12855817
Biological Process	GO:0010934	macrophage cytokine production	Tlr3	IDA		Mouse	PMID:18261938
Biological Process	GO:0008584	male gonad development	Tlr3	IEP		Rat	PMID:19703144\|RGD:5129498
Biological Process	GO:0000165	MAPK cascade	Tlr3	IMP		Mouse	PMID:18802055
Biological Process	GO:0001774	microglial cell activation	Tlr3	IDA		Rat	PMID:16973131\|RGD:1643119
Biological Process	GO:0097527	necroptotic signaling pathway	TLR3	IDA		Human	PMID:21737330
Biological Process	GO:0045766	positive regulation of angiogenesis	Tlr3	IGI	RNAcentral:URS00001F1DA8_10090	Mouse	MGI:MGI:5766647\|PMID:26934179
Biological Process	GO:0043065	positive regulation of apoptotic process	Tlr3	IEP		Rat	PMID:16027122\|RGD:5128770
Biological Process	GO:0032722	positive regulation of chemokine production	TLR3	IDA		Human	PMID:19740627
Biological Process	GO:0032722	positive regulation of chemokine production	Tlr3	IMP	MGI:MGI:3690535	Mouse	PMID:12855817
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Tlr3	IDA		Mouse	PMID:27830702
Biological Process	GO:0010628	positive regulation of gene expression	TLR3	IMP		Human	PMID:23817958
Biological Process	GO:0010628	positive regulation of gene expression	TLR3	IMP		Human	PMID:25754930
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Tlr3	IMP	MGI:MGI:3690535	Mouse	PMID:12855817
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Tlr3	IGI	MGI:MGI:1346877	Mouse	PMID:16260493
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Tlr3	IDA		Mouse	PMID:16260493
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Tlr3	IDA		Mouse	PMID:19734906
Biological Process	GO:0032727	positive regulation of interferon-alpha production	TLR3	IDA		Human	PMID:16286015
Biological Process	GO:0032728	positive regulation of interferon-beta production	TLR3	IMP		Human	PMID:12054664
Biological Process	GO:0032728	positive regulation of interferon-beta production	TLR3	IDA		Human	PMID:16286015
Biological Process	GO:0032728	positive regulation of interferon-beta production	Tlr3	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Tlr3	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0032755	positive regulation of interleukin-6 production	TLR3	IDA		Human	PMID:19740627
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tlr3	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tlr3	IDA		Mouse	PMID:18261938
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tlr3	IMP	MGI:MGI:2653138	Mouse	PMID:17008311
Biological Process	GO:0032757	positive regulation of interleukin-8 production	TLR3	IDA		Human	PMID:17128265
Biological Process	GO:0046330	positive regulation of JNK cascade	Tlr3	IDA		Mouse	PMID:16260493
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Tlr3	IDA		Mouse	PMID:18261938
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Tlr3	IMP	MGI:MGI:3690535	Mouse	PMID:12855817
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Tlr3	IMP	MGI:MGI:3690535	Mouse	PMID:12855817
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	TLR3	IDA		Human	PMID:19740627
Biological Process	GO:0034123	positive regulation of toll-like receptor signaling pathway	TLR3	IDA		Human	PMID:17128265
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tlr3	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tlr3	IGI	MGI:MGI:2176882	Mouse	PMID:18802055
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tlr3	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tlr3	IMP	MGI:MGI:2653138	Mouse	PMID:17008311
Biological Process	GO:0032481	positive regulation of type I interferon production	Tlr3	IDA		Mouse	PMID:18207576
Biological Process	GO:0032729	positive regulation of type II interferon production	TLR3	IDA		Human	PMID:16286015
Biological Process	GO:0034346	positive regulation of type III interferon production	Tlr3	IDA		Mouse	PMID:18207576
Biological Process	GO:0002730	regulation of dendritic cell cytokine production	Tlr3	IDA		Mouse	PMID:19047410
Biological Process	GO:0009617	response to bacterium	tlr3	IDA		Zfish	PMID:15829296
Biological Process	GO:0043331	response to dsRNA	Tlr3	IDA		Rat	PMID:16973131\|RGD:1643119
Biological Process	GO:0043330	response to exogenous dsRNA	TLR3	IDA		Human	PMID:21266579
Biological Process	GO:0043330	response to exogenous dsRNA	Tlr3	IMP	MGI:MGI:3690535	Mouse	PMID:12855817
Biological Process	GO:0009615	response to virus	Tlr3	IMP	MGI:MGI:2653138	Mouse	PMID:14993594
Biological Process	GO:0009615	response to virus	Tlr3	IEP		Rat	PMID:15661832\|RGD:5128798
Biological Process	GO:0009615	response to virus	tlr3	IDA		Zfish	PMID:15829296
Biological Process	GO:0009615	response to virus	tlr3	IDA		Zfish	PMID:16777275
Biological Process	GO:0002224	toll-like receptor signaling pathway	TLR3	IDA		Human	PMID:18172197
Biological Process	GO:0002224	toll-like receptor signaling pathway	Tlr3	IDA		Rat	PMID:16973131\|RGD:1643119
Biological Process	GO:0032606	type I interferon production	Tlr3	IDA		Mouse	PMID:18207576
Biological Process	GO:0034343	type III interferon production	Tlr3	IDA		Mouse	PMID:18207576

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.