Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLR4
  • Mouse genes Tlr4
  • Rat genes Tlr4
  • Zfish genes tlr4al,tlr4ba,tlr4bb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tlr4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TLR4	IPI	UniProtKB:O00206	Human	PMID:23059983
Molecular Function	GO:0042802	identical protein binding	TLR4	IPI	UniProtKB:O00206	Human	PMID:23155421
Molecular Function	GO:0001530	lipopolysaccharide binding	TLR4	IMP		Human	PMID:16514062
Molecular Function	GO:0001530	lipopolysaccharide binding	Tlr4	IDA		Rat	PMID:16973131|RGD:1643119
Molecular Function	GO:0001875	lipopolysaccharide immune receptor activity	TLR4	IDA		Human	PMID:19252480
Molecular Function	GO:0001875	lipopolysaccharide immune receptor activity	Tlr4	IDA		Mouse	MGI:MGI:5913054|PMID:28098138
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Tlr4	IPI	RGD:3329	Rat	PMID:14962484|RGD:1302746
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q9H0E2	Human	PMID:11441107
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:P58753	Human	PMID:11544529
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q6IA17	Human	PMID:12925853
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q9NPH5	Human	PMID:15356101
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q99836	Human	PMID:15728506
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q9Y6Y9	Human	PMID:15728506
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:P9WGU1	Human	PMID:16622205
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q9NPH5	Human	PMID:17064675
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q99836	Human	PMID:17126326
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:P58753	Human	PMID:17258210
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q86XR7	Human	PMID:17258210
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q99836	Human	PMID:17258210
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q9Y6Y9	Human	PMID:17803912
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q9Y6Y9	Human	PMID:19252480
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:P58753	Human	PMID:19509286
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q9Y2C9	Human	PMID:20037584
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q9Y6Y9	Human	PMID:20547845
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:P11226	Human	PMID:21383675
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:P58753	Human	PMID:21829704
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q86XR7	Human	PMID:21829704
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q99836	Human	PMID:21829704
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:P58753	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q86XR7	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:O15389	Human	PMID:25187624
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:O43699-3	Human	PMID:25187624
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q9Y336	Human	PMID:25187624
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:P24821	Human	PMID:29150600
Molecular Function	GO:0005515	protein binding	TLR4	IPI	UniProtKB:Q96A54	Human	PMID:29190778
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	UniProtKB:E9Q4P1	Mouse	MGI:MGI:5688815|PMID:25736436
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	UniProtKB:P31809|UniProtKB:P48025	Mouse	MGI:MGI:5478702|PMID:22496641
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	UniProtKB:Q9JHF9	Mouse	MGI:MGI:5914828|PMID:21857663
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	UniProtKB:P22366	Mouse	MGI:MGI:5441112|PMID:23023391
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	UniProtKB:Q3U0V2	Mouse	MGI:MGI:3806433|PMID:18719121
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	UniProtKB:P58242	Mouse	MGI:MGI:5689225|PMID:26095358
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	UniProtKB:Q3UU41	Mouse	MGI:MGI:5913054|PMID:28098138
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	UniProtKB:Q9JHF9	Mouse	MGI:MGI:3763315|PMID:17803912
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	UniProtKB:P22366	Mouse	MGI:MGI:6202827|PMID:29990310
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	UniProtKB:Q91Y57	Mouse	MGI:MGI:5616258|PMID:25187624
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	UniProtKB:Q9JHF9	Mouse	MGI:MGI:5426338|PMID:22532668
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	PR:P04918	Mouse	PMID:18820689
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	RGD:735043	Rat	PMID:14962484|RGD:1302746
Molecular Function	GO:0005515	protein binding	Tlr4	IPI	RGD:61306	Rat	PMID:23447644|RGD:10402845
Molecular Function	GO:0046982	protein heterodimerization activity	TLR4	IPI	UniProtKB:Q9Y2C9	Human	PMID:20037584
Molecular Function	GO:0038023	signaling receptor activity	TLR4	IDA		Human	PMID:15618008
Molecular Function	GO:0005102	signaling receptor binding	TLR4	IPI	UniProtKB:P16671,UniProtKB:Q9Y2C9	Human	PMID:20037584
Cellular Component	GO:0009986	cell surface	TLR4	IDA		Human	PMID:25204797
Cellular Component	GO:0009986	cell surface	Tlr4	IDA		Rat	PMID:16847070|RGD:1598585
Cellular Component	GO:0005737	cytoplasm	TLR4	IDA		Human	PMID:19740627
Cellular Component	GO:0005737	cytoplasm	TLR4	IPI	UniProtKB:P16671,UniProtKB:Q9Y2C9	Human	PMID:20037584
Cellular Component	GO:0005737	cytoplasm	Tlr4	IDA		Rat	PMID:16847070|RGD:1598585
Cellular Component	GO:0009897	external side of plasma membrane	TLR4	IDA		Human	PMID:16514062
Cellular Component	GO:0005794	Golgi apparatus	TLR4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0046696	lipopolysaccharide receptor complex	TLR4	IDA		Human	PMID:11274165
Cellular Component	GO:0046696	lipopolysaccharide receptor complex	TLR4	IDA		Human	PMID:19252480
Cellular Component	GO:0045121	membrane raft	Tlr4	IDA		Rat	PMID:16847070|RGD:1598585
Cellular Component	GO:0048471	perinuclear region of cytoplasm	TLR4	IDA		Human	PMID:15027902
Cellular Component	GO:0001891	phagocytic cup	TLR4	IDA		Human	PMID:30883606
Cellular Component	GO:0005886	plasma membrane	TLR4	IDA		Human	PMID:12055629
Cellular Component	GO:0005886	plasma membrane	TLR4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	TLR4	IDA		Human	PMID:11274165
Cellular Component	GO:0005886	plasma membrane	TLR4	IDA		Human	PMID:15027902
Cellular Component	GO:0005886	plasma membrane	TLR4	IDA		Human	PMID:16338228
Cellular Component	GO:0005886	plasma membrane	TLR4	IDA		Human	PMID:19740627
Cellular Component	GO:0005886	plasma membrane	Tlr4	IDA		Mouse	MGI:MGI:6244743|PMID:28096568
Cellular Component	GO:0005886	plasma membrane	Tlr4	IDA		Mouse	PMID:25549946
Cellular Component	GO:0032991	protein-containing complex	tlr4ba	IPI	ZFIN:ZDB-GENE-050320-35	Zfish	PMID:29518406
Cellular Component	GO:0043235	receptor complex	TLR4	IPI		Human	PMID:19252480
Cellular Component	GO:0043235	receptor complex	TLR4	IPI		Human	PMID:20037584
Cellular Component	GO:0043235	receptor complex	TLR4	IPI	UniProtKB:P16671,UniProtKB:Q9Y2C9	Human	PMID:20037584
Cellular Component	GO:0043235	receptor complex	Tlr4	IDA		Mouse	MGI:MGI:5913054|PMID:28098138
Biological Process	GO:0002218	activation of innate immune response	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:15661922
Biological Process	GO:0014002	astrocyte development	Tlr4	IMP		Mouse	PMID:22577135
Biological Process	GO:0042100	B cell proliferation	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0002322	B cell proliferation involved in immune response	Tlr4	IMP		Mouse	PMID:10880523
Biological Process	GO:1904646	cellular response to amyloid-beta	TLR4	IDA		Human	PMID:20037584
Biological Process	GO:1904646	cellular response to amyloid-beta	TLR4	IGI	UniProtKB:P16671,UniProtKB:Q9Y2C9	Human	PMID:20037584
Biological Process	GO:0071222	cellular response to lipopolysaccharide	TLR4	IDA		Human	PMID:11432859
Biological Process	GO:0071222	cellular response to lipopolysaccharide	TLR4	IGI	RNAcentral:URS000026261D_9606	Human	PMID:30321456
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Tlr4	IDA		Mouse	MGI:MGI:6244743|PMID:28096568
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Tlr4	IMP		Mouse	MGI:MGI:4421230|PMID:20051628
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Tlr4	IMP		Mouse	MGI:MGI:5462034|PMID:21880694
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Tlr4	IMP	MGI:MGI:1860755	Mouse	PMID:14691481
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Tlr4	IDA		Mouse	PMID:10880523
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Tlr4	IMP		Mouse	PMID:10880523
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Tlr4	IDA		Mouse	PMID:24740015
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Tlr4	IEP		Rat	PMID:20438866|RGD:7777075
Biological Process	GO:0071223	cellular response to lipoteichoic acid	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0071260	cellular response to mechanical stimulus	TLR4	IEP		Human	PMID:19593445
Biological Process	GO:0071260	cellular response to mechanical stimulus	Tlr4	IEP		Rat	PMID:20202224|RGD:4144075
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	TLR4	IDA		Human	PMID:20037584
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	Tlr4	IGI	UniProtKB:Q9Y2C9	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	Tlr4	IMP		Mouse	MGI:MGI:5462034|PMID:21880694
Biological Process	GO:0071300	cellular response to retinoic acid	Tlr4	IEP		Rat	PMID:20438866|RGD:7777075
Biological Process	GO:0071346	cellular response to type II interferon	TLR4	IDA		Human	PMID:11672593
Biological Process	GO:0042742	defense response to bacterium	TLR4	IGI	RNAcentral:URS000026261D_9606	Human	PMID:30321456
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:15661922
Biological Process	GO:0032497	detection of lipopolysaccharide	TLR4	IDA		Human	PMID:19252480
Biological Process	GO:0032497	detection of lipopolysaccharide	Tlr4	IDA		Mouse	MGI:MGI:5913054|PMID:28098138
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Tlr4	IMP		Rat	PMID:27760212|RGD:12910551
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Tlr4	IMP		Rat	PMID:27760212|RGD:12910551
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0010467	gene expression	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:18509511
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Tlr4	IDA		Mouse	PMID:16260493
Biological Process	GO:0007252	I-kappaB phosphorylation	TLR4	IDA		Human	PMID:19740627
Biological Process	GO:0007252	I-kappaB phosphorylation	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:18820689
Biological Process	GO:0016064	immunoglobulin mediated immune response	Tlr4	IEP		Rat	PMID:19257980|RGD:2312508
Biological Process	GO:0006954	inflammatory response	Tlr4	IMP		Mouse	MGI:MGI:5462034|PMID:21880694
Biological Process	GO:0006954	inflammatory response	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:18509511
Biological Process	GO:0006954	inflammatory response	Tlr4	IEP		Rat	PMID:15204789|RGD:1624166
Biological Process	GO:0002758	innate immune response-activating signaling pathway	Tlr4	IMP		Rat	PMID:19226379|RGD:2312509
Biological Process	GO:0032608	interferon-beta production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:15661922
Biological Process	GO:0032613	interleukin-10 production	Tlr4	IDA		Mouse	PMID:21609717
Biological Process	GO:0032635	interleukin-6 production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0032635	interleukin-6 production	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0060729	intestinal epithelial structure maintenance	Tlr4	IMP		Mouse	MGI:MGI:4421230|PMID:20051628
Biological Process	GO:0007254	JNK cascade	Tlr4	IGI	MGI:MGI:1346877	Mouse	PMID:16260493
Biological Process	GO:0007254	JNK cascade	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0007254	JNK cascade	Tlr4	IDA		Mouse	PMID:16260493
Biological Process	GO:0006691	leukotriene metabolic process	Tlr4	IDA		Rat	PMID:21765618|RGD:7241098
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	TLR4	IGI	UniProtKB:O95711	Human	PMID:10880523
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	TLR4	IGI	UniProtKB:Q9Y6Y9	Human	PMID:10880523
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Tlr4	IDA		Mouse	MGI:MGI:5913054|PMID:28098138
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Tlr4	IGI	MGI:MGI:1321404	Mouse	PMID:10880523
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Tlr4	IGI	MGI:MGI:1341909	Mouse	PMID:10880523
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Tlr4	IGI	MGI:MGI:1194924	Mouse	PMID:10880523
Biological Process	GO:0046651	lymphocyte proliferation	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10607756
Biological Process	GO:0042116	macrophage activation	TLR4	IMP		Human	PMID:10835634
Biological Process	GO:0010934	macrophage cytokine production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0010934	macrophage cytokine production	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0010934	macrophage cytokine production	Tlr4	IMP	MGI:MGI:1857718	Mouse	PMID:10623794
Biological Process	GO:0010934	macrophage cytokine production	Tlr4	IDA		Mouse	PMID:21609717
Biological Process	GO:0010934	macrophage cytokine production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10607756
Biological Process	GO:0010934	macrophage cytokine production	Tlr4	IMP	MGI:MGI:1860755	Mouse	PMID:14691481
Biological Process	GO:0010934	macrophage cytokine production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:15661922
Biological Process	GO:0045342	MHC class II biosynthetic process	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0014004	microglia differentiation	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:18509511
Biological Process	GO:0001774	microglial cell activation	Tlr4	IDA		Rat	PMID:16973131|RGD:1643119
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TLR4	IDA		Human	PMID:20037584
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Tlr4	IGI	UniProtKB:Q9EPW9	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Tlr4	IMP		Mouse	MGI:MGI:6101064|PMID:26370079
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Tlr4	IMP		Mouse	MGI:MGI:4421230|PMID:20051628
Biological Process	GO:0032700	negative regulation of interleukin-17 production	Tlr4	IMP		Mouse	MGI:MGI:3773594|PMID:18203139
Biological Process	GO:0032700	negative regulation of interleukin-17 production	Tlr4	IMP		Mouse	MGI:MGI:4421230|PMID:20051628
Biological Process	GO:0032707	negative regulation of interleukin-23 production	Tlr4	IMP		Mouse	MGI:MGI:3773594|PMID:18203139
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Tlr4	IMP		Mouse	MGI:MGI:4421230|PMID:20051628
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Tlr4	IMP		Mouse	MGI:MGI:3773594|PMID:18203139
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Tlr4	IMP		Mouse	MGI:MGI:4421230|PMID:20051628
Biological Process	GO:0032689	negative regulation of type II interferon production	Tlr4	IMP		Mouse	MGI:MGI:4421230|PMID:20051628
Biological Process	GO:0022008	neurogenesis	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:18509511
Biological Process	GO:0006809	nitric oxide biosynthetic process	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0002537	nitric oxide production involved in inflammatory response	Tlr4	IMP	MGI:MGI:1857718	Mouse	PMID:10623794
Biological Process	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0006909	phagocytosis	TLR4	IDA		Human	PMID:30883606
Biological Process	GO:0043065	positive regulation of apoptotic process	Tlr4	IMP		Rat	PMID:16272348|RGD:1598594
Biological Process	GO:0030890	positive regulation of B cell proliferation	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	TLR4	IDA		Human	PMID:11672593
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	TLR4	IMP		Human	PMID:21329689
Biological Process	GO:0032722	positive regulation of chemokine production	TLR4	IDA		Human	PMID:19740627
Biological Process	GO:0032722	positive regulation of chemokine production	Tlr4	IDA		Mouse	MGI:MGI:4456948|PMID:15356140
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	TLR4	IMP		Human	PMID:30321456
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Tlr4	IGI	UniProtKB:Q9Y2C9	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0043388	positive regulation of DNA binding	Tlr4	IMP		Rat	PMID:16272348|RGD:1598594
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Tlr4	IMP		Rat	PMID:16272348|RGD:1598594
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0010628	positive regulation of gene expression	TLR4	IMP		Human	PMID:23817958
Biological Process	GO:0010628	positive regulation of gene expression	Tlr4	IGI	UniProtKB:P05067:PRO_0000000092	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0010628	positive regulation of gene expression	Tlr4	IMP		Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0010628	positive regulation of gene expression	Tlr4	IGI	UniProtKB:Q9EPW9	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0010628	positive regulation of gene expression	Tlr4	IMP		Mouse	MGI:MGI:5462034|PMID:21880694
Biological Process	GO:1901534	positive regulation of hematopoietic progenitor cell differentiation	tlr4bb	IMP	ZFIN:ZDB-MRPHLNO-110427-2	Zfish	PMID:25540193
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Tlr4	IDA		Mouse	PMID:19734906
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Tlr4	IDA		Mouse	PMID:16260493
Biological Process	GO:0050729	positive regulation of inflammatory response	TLR4	IMP		Human	PMID:21329689
Biological Process	GO:0050729	positive regulation of inflammatory response	Tlr4	IGI	UniProtKB:O00206	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0050729	positive regulation of inflammatory response	Tlr4	IMP		Rat	PMID:16651628|RGD:1598593
Biological Process	GO:0032727	positive regulation of interferon-alpha production	Tlr4	IDA		Mouse	MGI:MGI:4456948|PMID:15356140
Biological Process	GO:0032728	positive regulation of interferon-beta production	Tlr4	IDA		Mouse	MGI:MGI:4456948|PMID:15356140
Biological Process	GO:0032728	positive regulation of interferon-beta production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:15661922
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	TLR4	IDA		Human	PMID:11432859
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Tlr4	IDA		Mouse	MGI:MGI:5546292|PMID:23812099
Biological Process	GO:0032732	positive regulation of interleukin-1 production	Tlr4	IDA		Mouse	MGI:MGI:4456948|PMID:15356140
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Tlr4	IDA		Mouse	MGI:MGI:4456948|PMID:15356140
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Tlr4	IDA		Mouse	PMID:21609717
Biological Process	GO:0032735	positive regulation of interleukin-12 production	TLR4	IDA		Human	PMID:15027902
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Tlr4	IDA		Mouse	MGI:MGI:5913054|PMID:28098138
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Tlr4	IDA		Mouse	MGI:MGI:4456948|PMID:15356140
Biological Process	GO:0032755	positive regulation of interleukin-6 production	TLR4	IDA		Human	PMID:19740627
Biological Process	GO:0032755	positive regulation of interleukin-6 production	TLR4	IMP		Human	PMID:21329689
Biological Process	GO:0032755	positive regulation of interleukin-6 production	TLR4	IMP		Human	PMID:30321456
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tlr4	IDA		Mouse	MGI:MGI:4456948|PMID:15356140
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tlr4	IDA		Mouse	MGI:MGI:5913054|PMID:28098138
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tlr4	IMP	MGI:MGI:1860755	Mouse	PMID:14691481
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0032757	positive regulation of interleukin-8 production	TLR4	IDA		Human	PMID:17951129
Biological Process	GO:0032757	positive regulation of interleukin-8 production	TLR4	IDA		Human	PMID:19740627
Biological Process	GO:0032757	positive regulation of interleukin-8 production	TLR4	IDA		Human	PMID:21329689
Biological Process	GO:0046330	positive regulation of JNK cascade	Tlr4	IGI	MGI:MGI:1346877	Mouse	PMID:16260493
Biological Process	GO:0046330	positive regulation of JNK cascade	Tlr4	IDA		Mouse	PMID:16260493
Biological Process	GO:0046330	positive regulation of JNK cascade	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0050671	positive regulation of lymphocyte proliferation	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10607756
Biological Process	GO:0043032	positive regulation of macrophage activation	Tlr4	IGI	UniProtKB:Q9Y2C9	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10607756
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Tlr4	IDA		Mouse	PMID:21609717
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Tlr4	IMP	MGI:MGI:1860755	Mouse	PMID:14691481
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:15661922
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Tlr4	IMP	MGI:MGI:1857718	Mouse	PMID:10623794
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Tlr4	IMP		Mouse	MGI:MGI:4421230|PMID:20051628
Biological Process	GO:1904466	positive regulation of matrix metallopeptidase secretion	TLR4	IMP		Human	PMID:21329689
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TLR4	IMP		Human	PMID:30233718
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TLR4	IDA		Human	PMID:12594207
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TLR4	IGI	UniProtKB:P05067:PRO_0000000092,UniProtKB:P16671,UniProtKB:Q9Y2C9	Human	PMID:20037584
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TLR4	IGI	UniProtKB:P16671,UniProtKB:Q9Y2C9	Human	PMID:20037584
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TLR4	IDA		Human	PMID:29038465
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Tlr4	IMP		Mouse	MGI:MGI:6099204|PMID:29038465
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Tlr4	IMP		Rat	PMID:16651628|RGD:1598593
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	TLR4	IDA		Human	PMID:19740627
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Tlr4	IGI	UniProtKB:P05067:PRO_0000000092	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Tlr4	IDA		Mouse	MGI:MGI:4456948|PMID:15356140
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	Tlr4	IDA		Mouse	MGI:MGI:5546292|PMID:23812099
Biological Process	GO:0070430	positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:1903223	positive regulation of oxidative stress-induced neuron death	Tlr4	IGI	UniProtKB:P05067:PRO_0000000092	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Tlr4	IDA		Rat	PMID:12616494|RGD:634467
Biological Process	GO:0010572	positive regulation of platelet activation	Tlr4	IMP		Mouse	MGI:MGI:3838274|PMID:16514062
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	Tlr4	IMP		Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Tlr4	IMP		Mouse	MGI:MGI:5462034|PMID:21880694
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Tlr4	IMP		Mouse	MGI:MGI:5462034|PMID:21880694
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tlr4	IDA		Mouse	MGI:MGI:4456948|PMID:15356140
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	TLR4	IDA		Human	PMID:17951129
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	TLR4	IMP		Human	PMID:30321456
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tlr4	IDA		Mouse	MGI:MGI:4456948|PMID:15356140
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tlr4	IMP	MGI:MGI:1857718	Mouse	PMID:10623794
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tlr4	IMP	MGI:MGI:1860755	Mouse	PMID:14691481
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10607756
Biological Process	GO:0032729	positive regulation of type II interferon production	Tlr4	IMP		Mouse	MGI:MGI:3773594|PMID:18203139
Biological Process	GO:0002730	regulation of dendritic cell cytokine production	Tlr4	IDA		Mouse	PMID:19047410
Biological Process	GO:1901532	regulation of hematopoietic progenitor cell differentiation	tlr4bb	IGI	ZFIN:ZDB-GENE-040426-2227	Zfish	PMID:25540193
Biological Process	GO:0050727	regulation of inflammatory response	Tlr4	IMP		Mouse	MGI:MGI:3773594|PMID:18203139
Biological Process	GO:0051930	regulation of sensory perception of pain	Tlr4	IMP		Rat	PMID:20478276|RGD:4144073
Biological Process	GO:0032680	regulation of tumor necrosis factor production	Tlr4	IMP		Rat	PMID:24199847|RGD:12910488
Biological Process	GO:0014823	response to activity	Tlr4	IEP		Rat	PMID:20007518|RGD:4144081
Biological Process	GO:0014823	response to activity	Tlr4	IEP		Rat	PMID:20369365|RGD:4144074
Biological Process	GO:0009617	response to bacterium	Tlr4	IMP		Mouse	PMID:11294571
Biological Process	GO:0045471	response to ethanol	Tlr4	IMP		Rat	PMID:16272348|RGD:1598594
Biological Process	GO:0070542	response to fatty acid	Tlr4	IDA		Rat	PMID:19144836|RGD:2312510
Biological Process	GO:0051384	response to glucocorticoid	Tlr4	IEP		Rat	PMID:19141191|RGD:8693609
Biological Process	GO:1990268	response to gold nanoparticle	Tlr4	IEP		Rat	PMID:23150627|RGD:7815044
Biological Process	GO:0001666	response to hypoxia	Tlr4	IEP		Rat	PMID:15535030|RGD:2312731
Biological Process	GO:0032868	response to insulin	Tlr4	IEP		Rat	PMID:16740310|RGD:2312491
Biological Process	GO:0032496	response to lipopolysaccharide	TLR4	IDA		Human	PMID:12594207
Biological Process	GO:0032496	response to lipopolysaccharide	TLR4	IDA		Human	PMID:14607928
Biological Process	GO:0032496	response to lipopolysaccharide	Tlr4	IGI	MGI:MGI:1270861	Mouse	PMID:11489994
Biological Process	GO:0032496	response to lipopolysaccharide	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0032496	response to lipopolysaccharide	Tlr4	IMP	MGI:MGI:1860755	Mouse	PMID:10229796
Biological Process	GO:0032496	response to lipopolysaccharide	Tlr4	IMP	MGI:MGI:1857718	Mouse	PMID:12055258
Biological Process	GO:0032496	response to lipopolysaccharide	Tlr4	IMP	MGI:MGI:1857718	Mouse	PMID:10229796
Biological Process	GO:0032496	response to lipopolysaccharide	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10607756
Biological Process	GO:0032496	response to lipopolysaccharide	Tlr4	IDA		Rat	PMID:16973131|RGD:1643119
Biological Process	GO:0032496	response to lipopolysaccharide	Tlr4	IEP		Rat	PMID:17167854|RGD:1620770
Biological Process	GO:0043278	response to morphine	Tlr4	IEP		Rat	PMID:18599265|RGD:7777128
Biological Process	GO:0006979	response to oxidative stress	Tlr4	IMP		Rat	PMID:16847070|RGD:1598585
Biological Process	GO:0032570	response to progesterone	Tlr4	IEP		Rat	PMID:18316784|RGD:2312713
Biological Process	GO:0032526	response to retinoic acid	Tlr4	IEP		Rat	PMID:20438866|RGD:7777075
Biological Process	GO:0009636	response to toxic substance	Tlr4	IEP		Rat	PMID:15535030|RGD:2312731
Biological Process	GO:0003009	skeletal muscle contraction	Tlr4	IEP		Rat	PMID:20007518|RGD:4144081
Biological Process	GO:0051403	stress-activated MAPK cascade	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	TLR4	IDA		Human	PMID:15618008
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	Tlr4	IDA		Mouse	MGI:MGI:5913054|PMID:28098138
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	Tlr4	IDA		Mouse	PMID:25549946
Biological Process	GO:0002224	toll-like receptor signaling pathway	TLR4	IDA		Human	PMID:14607928
Biological Process	GO:0002224	toll-like receptor signaling pathway	Tlr4	IDA		Rat	PMID:16973131|RGD:1643119
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Tlr4	IGI	UniProtKB:Q9EPW9	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0032640	tumor necrosis factor production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10549626
Biological Process	GO:0032640	tumor necrosis factor production	Tlr4	IDA		Mouse	PMID:18261938
Biological Process	GO:0032640	tumor necrosis factor production	Tlr4	IMP	MGI:MGI:1857718	Mouse	PMID:10623794
Biological Process	GO:0032640	tumor necrosis factor production	Tlr4	IMP	MGI:MGI:1860755	Mouse	PMID:14691481
Biological Process	GO:0032640	tumor necrosis factor production	Tlr4	IMP	MGI:MGI:1860885	Mouse	PMID:10607756
Biological Process	GO:0032609	type II interferon production	Tlr4	IGI	MGI:MGI:1270861	Mouse	PMID:11489994
Biological Process	GO:0002246	wound healing involved in inflammatory response	Tlr4	IMP		Mouse	MGI:MGI:5462034|PMID:21880694

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern