Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLR6
  • Mouse genes Tlr6
  • Rat genes Tlr6
  • Zfish genes tlr1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tlr6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042498	diacyl lipopeptide binding	Tlr6	IDA		Mouse	PMID:19931471
Molecular Function	GO:0042802	identical protein binding	TLR6	IPI	UniProtKB:Q9Y2C9	Human	PMID:23155421
Molecular Function	GO:0042802	identical protein binding	TLR6	IDA		Human	PMID:25088687
Molecular Function	GO:0071723	lipopeptide binding	Tlr6	IMP		Mouse	MGI:MGI:2137801|PMID:11431423
Molecular Function	GO:0071723	lipopeptide binding	Tlr6	IMP		Rat	PMID:18353287|RGD:5684896
Molecular Function	GO:0005515	protein binding	TLR6	IPI	UniProtKB:O60603,UniProtKB:P08571,UniProtKB:P16671	Human	PMID:16880211
Molecular Function	GO:0005515	protein binding	TLR6	IPI	UniProtKB:O00206	Human	PMID:20037584
Molecular Function	GO:0005515	protein binding	TLR6	IPI	UniProtKB:O60603	Human	PMID:20067962
Molecular Function	GO:0005515	protein binding	TLR6	IPI	UniProtKB:O60603	Human	PMID:23155421
Molecular Function	GO:0005515	protein binding	Tlr6	IPI	PR:Q9QUN7	Mouse	PMID:19931471
Molecular Function	GO:0046982	protein heterodimerization activity	TLR6	IPI	UniProtKB:O00206	Human	PMID:20037584
Molecular Function	GO:0005102	signaling receptor binding	TLR6	IPI	UniProtKB:O00206,UniProtKB:P16671	Human	PMID:20037584
Molecular Function	GO:0035663	Toll-like receptor 2 binding	TLR6	IPI	UniProtKB:O60603	Human	PMID:16880211
Cellular Component	GO:0005794	Golgi apparatus	TLR6	IDA		Human	PMID:16880211
Cellular Component	GO:0045121	membrane raft	TLR6	IDA		Human	PMID:16880211
Cellular Component	GO:0043235	receptor complex	TLR6	IPI		Human	PMID:20037584
Cellular Component	GO:0043235	receptor complex	TLR6	IPI	UniProtKB:O00206,UniProtKB:P16671	Human	PMID:20037584
Cellular Component	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex	TLR6	IPI		Human	PMID:23155421
Cellular Component	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex	Tlr6	IDA		Mouse	PMID:19931471
Biological Process	GO:1904646	cellular response to amyloid-beta	TLR6	IDA		Human	PMID:20037584
Biological Process	GO:1904646	cellular response to amyloid-beta	TLR6	IGI	UniProtKB:O00206,UniProtKB:P16671	Human	PMID:20037584
Biological Process	GO:0071726	cellular response to diacyl bacterial lipopeptide	TLR6	IDA		Human	PMID:19931471
Biological Process	GO:0071726	cellular response to diacyl bacterial lipopeptide	TLR6	IDA		Human	PMID:16880211
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	TLR6	IDA		Human	PMID:20037584
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	Tlr6	IGI	UniProtKB:O00206	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0042496	detection of diacyl bacterial lipopeptide	TLR6	IDA		Human	PMID:19931471
Biological Process	GO:0006954	inflammatory response	Tlr6	IDA		Rat	PMID:16154916|RGD:4889539
Biological Process	GO:0001774	microglial cell activation	Tlr6	IDA		Rat	PMID:16973131|RGD:1643119
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TLR6	IDA		Human	PMID:20037584
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Tlr6	IGI	UniProtKB:Q9QUK6	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0032717	negative regulation of interleukin-8 production	TLR6	IGI	ComplexPortal:CPX-1134,UniProtKB:O60603	Human	PMID:22198949
Biological Process	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	TLR6	IGI	ComplexPortal:CPX-1134,UniProtKB:O60603	Human	PMID:22198949
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Tlr6	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5307186|PMID:22198949
Biological Process	GO:0046209	nitric oxide metabolic process	Tlr6	IDA		Rat	PMID:16973131|RGD:1643119
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Tlr6	IGI	UniProtKB:O00206	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0010628	positive regulation of gene expression	Tlr6	IMP		Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0010628	positive regulation of gene expression	Tlr6	IGI	UniProtKB:P05067:PRO_0000000092	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0010628	positive regulation of gene expression	Tlr6	IGI	UniProtKB:Q9QUK6	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TLR6	IDA		Human	PMID:10231569
Biological Process	GO:0050729	positive regulation of inflammatory response	Tlr6	IGI	UniProtKB:O00206	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Tlr6	IDA		Mouse	MGI:MGI:5546292|PMID:23812099
Biological Process	GO:0043507	positive regulation of JUN kinase activity	TLR6	IDA		Human	PMID:10231569
Biological Process	GO:0043032	positive regulation of macrophage activation	Tlr6	IGI	UniProtKB:O00206	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TLR6	IGI	UniProtKB:O00206,UniProtKB:P05067:PRO_0000000092,UniProtKB:P16671	Human	PMID:20037584
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TLR6	IGI	UniProtKB:O00206,UniProtKB:P16671	Human	PMID:20037584
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Tlr6	IGI	UniProtKB:O00206,UniProtKB:P05067:PRO_0000000092,UniProtKB:P16671	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	Tlr6	IDA		Mouse	MGI:MGI:5546292|PMID:23812099
Biological Process	GO:1903223	positive regulation of oxidative stress-induced neuron death	Tlr6	IGI	UniProtKB:P05067:PRO_0000000092	Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	Tlr6	IMP		Mouse	MGI:MGI:4438693|PMID:20037584
Biological Process	GO:0032493	response to bacterial lipoprotein	Tlr6	IDA		Rat	PMID:16973131|RGD:1643119
Biological Process	GO:0002224	toll-like receptor signaling pathway	Tlr6	IDA		Rat	PMID:16973131|RGD:1643119
Biological Process	GO:0002224	toll-like receptor signaling pathway	Tlr6	IMP		Rat	PMID:18353287|RGD:5684896
Biological Process	GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	TLR6	IDA		Human	PMID:23626692
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Tlr6	IGI	UniProtKB:Q9QUK6	Mouse	MGI:MGI:4438693|PMID:20037584

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern