Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tlr9

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TLR9
- Mouse genes Tlr9
- Rat genes Tlr9
- Zfish genes tlr9
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tlr9

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005149	interleukin-1 receptor binding	TLR9	IPI	UniProtKB:Q6IA17	Human	PMID:12925853
Molecular Function	GO:0005515	protein binding	Tlr9	IPI	UniProtKB:Q8VCW4	Mouse	MGI:MGI:3828189\|PMID:18931679
Molecular Function	GO:0005515	protein binding	Tlr9	IPI	UniProtKB:P58242	Mouse	MGI:MGI:5689225\|PMID:26095358
Molecular Function	GO:0005515	protein binding	Tlr9	IPI	UniProtKB:P11507	Mouse	MGI:MGI:5613436\|PMID:24610369
Molecular Function	GO:0005515	protein binding	Tlr9	IPI	UniProtKB:P22366	Mouse	MGI:MGI:3826712\|PMID:18820679
Molecular Function	GO:0005515	protein binding	Tlr9	IPI	UniProtKB:Q8VCW4	Mouse	MGI:MGI:4457250\|PMID:17452530
Molecular Function	GO:0005515	protein binding	Tlr9	IPI	PR:Q6SJQ5	Mouse	PMID:21940676
Molecular Function	GO:0035197	siRNA binding	TLR9	IMP		Human	PMID:15723075
Molecular Function	GO:0045322	unmethylated CpG binding	Tlr9	IDA		Rat	PMID:16973131\|RGD:1643119
Cellular Component	GO:0016324	apical plasma membrane	TLR9	IDA		Human	PMID:17128265
Cellular Component	GO:0016323	basolateral plasma membrane	TLR9	IDA		Human	PMID:17128265
Cellular Component	GO:0005737	cytoplasm	TLR9	IDA		Human	PMID:19740627
Cellular Component	GO:0032009	early phagosome	Tlr9	IDA		Mouse	MGI:MGI:3776596\|PMID:18305481
Cellular Component	GO:0036019	endolysosome	Tlr9	IMP		Mouse	MGI:MGI:3828189\|PMID:18931679
Cellular Component	GO:0036019	endolysosome	Tlr9	IDA		Mouse	MGI:MGI:6274965\|PMID:25917084
Cellular Component	GO:0036019	endolysosome	Tlr9	IGI	UniProtKB:Q8VCW4	Mouse	MGI:MGI:3826712\|PMID:18820679
Cellular Component	GO:0005783	endoplasmic reticulum	Tlr9	IDA		Mouse	MGI:MGI:3776596\|PMID:18305481
Cellular Component	GO:0005783	endoplasmic reticulum	tlr9	IDA		Zfish	PMID:24282308
Cellular Component	GO:0005768	endosome	Tlr9	IDA		Mouse	MGI:MGI:3776596\|PMID:18305481
Cellular Component	GO:0005768	endosome	Tlr9	IDA		Mouse	PMID:20847273
Cellular Component	GO:0005764	lysosome	Tlr9	IDA		Mouse	MGI:MGI:3826712\|PMID:18820679
Cellular Component	GO:0005764	lysosome	Tlr9	IDA		Mouse	MGI:MGI:3776596\|PMID:18305481
Cellular Component	GO:0045335	phagocytic vesicle	Tlr9	IGI	UniProtKB:Q8VCW4	Mouse	MGI:MGI:3826712\|PMID:18820679
Cellular Component	GO:0005886	plasma membrane	TLR9	IDA		Human	PMID:19740627
Cellular Component	GO:0005886	plasma membrane	Tlr9	IDA		Mouse	PMID:16415873
Cellular Component	GO:0005886	plasma membrane	Tlr9	IDA		Rat	PMID:22785180\|RGD:7248431
Biological Process	GO:0002218	activation of innate immune response	Tlr9	IDA		Mouse	MGI:MGI:5887188\|PMID:25686612
Biological Process	GO:0019731	antibacterial humoral response	tlr9	IDA		Zfish	PMID:24282308
Biological Process	GO:1902350	cellular response to chloroquine	Tlr9	IDA		Mouse	PMID:17475835
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Tlr9	IEP		Rat	PMID:20655116\|RGD:5130179
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Tlr9	IEP		Rat	PMID:21308757\|RGD:5129495
Biological Process	GO:0071248	cellular response to metal ion	Tlr9	IEP		Rat	PMID:17415764\|RGD:5130196
Biological Process	GO:0071248	cellular response to metal ion	Tlr9	IEP		Rat	PMID:21308757\|RGD:5129495
Biological Process	GO:0050829	defense response to Gram-negative bacterium	TLR9	IMP		Human	PMID:22427638
Biological Process	GO:0051607	defense response to virus	Tlr9	IGI	MGI:MGI:2429859	Mouse	PMID:18250457
Biological Process	GO:0051607	defense response to virus	Tlr9	IMP		Rat	PMID:17202329\|RGD:2301335
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Tlr9	IDA		Mouse	MGI:MGI:3826712\|PMID:18820679
Biological Process	GO:0007252	I-kappaB phosphorylation	TLR9	IDA		Human	PMID:19740627
Biological Process	GO:0006955	immune response	Tlr9	IMP	MGI:MGI:2660562	Mouse	PMID:11130078
Biological Process	GO:0030277	maintenance of gastrointestinal epithelium	Tlr9	IMP		Mouse	MGI:MGI:4399015\|PMID:17128265
Biological Process	GO:0008584	male gonad development	Tlr9	IEP		Rat	PMID:19703144\|RGD:5129498
Biological Process	GO:0001774	microglial cell activation	Tlr9	IDA		Rat	PMID:16973131\|RGD:1643119
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Tlr9	IPI	UniProtKB:P22366	Mouse	MGI:MGI:3826712\|PMID:18820679
Biological Process	GO:1901895	negative regulation of ATPase-coupled calcium transmembrane transporter activity	TLR9	IDA		Human	PMID:24610369
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Tlr9	IGI	MGI:MGI:1922072	Mouse	PMID:23109291
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Tlr9	IMP		Mouse	MGI:MGI:3773594\|PMID:18203139
Biological Process	GO:0032717	negative regulation of interleukin-8 production	TLR9	IDA		Human	PMID:17128265
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	TLR9	IDA		Human	PMID:17128265
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	TLR9	IDA		Human	PMID:17128265
Biological Process	GO:0010508	positive regulation of autophagy	Tlr9	IDA		Rat	PMID:18632594\|RGD:2301341
Biological Process	GO:0050871	positive regulation of B cell activation	TLR9	IDA		Human	PMID:23857366
Biological Process	GO:0030890	positive regulation of B cell proliferation	TLR9	IDA		Human	PMID:23857366
Biological Process	GO:0032722	positive regulation of chemokine production	TLR9	IDA		Human	PMID:19740627
Biological Process	GO:0001819	positive regulation of cytokine production	Tlr9	IDA		Mouse	MGI:MGI:5887192\|PMID:21402738
Biological Process	GO:0010628	positive regulation of gene expression	TLR9	IDA		Human	PMID:24409285
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	TLR9	IDA		Human	PMID:24409285
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TLR9	IDA		Human	PMID:17128265
Biological Process	GO:0002639	positive regulation of immunoglobulin production	TLR9	IDA		Human	PMID:23857366
Biological Process	GO:0032727	positive regulation of interferon-alpha production	TLR9	IDA		Human	PMID:16286015
Biological Process	GO:0032728	positive regulation of interferon-beta production	TLR9	IDA		Human	PMID:16286015
Biological Process	GO:0032728	positive regulation of interferon-beta production	Tlr9	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Tlr9	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Tlr9	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0032741	positive regulation of interleukin-18 production	Tlr9	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0032755	positive regulation of interleukin-6 production	TLR9	IDA		Human	PMID:19740627
Biological Process	GO:0032755	positive regulation of interleukin-6 production	TLR9	IDA		Human	PMID:24409285
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tlr9	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0032757	positive regulation of interleukin-8 production	TLR9	IDA		Human	PMID:17128265
Biological Process	GO:0032757	positive regulation of interleukin-8 production	TLR9	IDA		Human	PMID:19740627
Biological Process	GO:0032757	positive regulation of interleukin-8 production	TLR9	IDA		Human	PMID:24409285
Biological Process	GO:0043507	positive regulation of JUN kinase activity	TLR9	IDA		Human	PMID:17128265
Biological Process	GO:0043410	positive regulation of MAPK cascade	TLR9	IDA		Human	PMID:23857366
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TLR9	IDA		Human	PMID:17128265
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Tlr9	IDA		Mouse	MGI:MGI:5887188\|PMID:25686612
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	TLR9	IDA		Human	PMID:19740627
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Tlr9	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	Tlr9	IMP		Mouse	MGI:MGI:3828189\|PMID:18931679
Biological Process	GO:0034123	positive regulation of toll-like receptor signaling pathway	TLR9	IDA		Human	PMID:17128265
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tlr9	IMP		Mouse	MGI:MGI:4399015\|PMID:17128265
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tlr9	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tlr9	IMP		Mouse	MGI:MGI:3828189\|PMID:18931679
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tlr9	IDA		Mouse	MGI:MGI:4456948\|PMID:15356140
Biological Process	GO:0032729	positive regulation of type II interferon production	TLR9	IDA		Human	PMID:16286015
Biological Process	GO:0050864	regulation of B cell activation	Tlr9	IGI	MGI:MGI:1922072	Mouse	PMID:23109291
Biological Process	GO:0045577	regulation of B cell differentiation	TLR9	IDA		Human	PMID:23857366
Biological Process	GO:0002730	regulation of dendritic cell cytokine production	Tlr9	IDA		Mouse	PMID:19047410
Biological Process	GO:0050727	regulation of inflammatory response	Tlr9	IMP		Mouse	MGI:MGI:3773594\|PMID:18203139
Biological Process	GO:0001932	regulation of protein phosphorylation	Tlr9	IDA		Mouse	PMID:24740015
Biological Process	GO:0034163	regulation of toll-like receptor 9 signaling pathway	TLR9	IDA		Human	PMID:23857366
Biological Process	GO:0009615	response to virus	Tlr9	IMP	MGI:MGI:3038816	Mouse	PMID:14993594
Biological Process	GO:0002224	toll-like receptor signaling pathway	Tlr9	IDA		Rat	PMID:16973131\|RGD:1643119
Biological Process	GO:0002224	toll-like receptor signaling pathway	tlr9	IDA		Zfish	PMID:24282308

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.