Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLX2
  • Mouse genes Tlx2
  • Rat genes Tlx2
  • Zfish genes tlx2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tlx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	TLX2	IDA		Human	PMID:10869550
Molecular Function	GO:0005515	protein binding	TLX2	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TLX2	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Tlx2	IPI	PR:P68510	Mouse	PMID:9738002
Molecular Function	GO:0043565	sequence-specific DNA binding	TLX2	IDA		Human	PMID:10869550
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TLX2	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Tlx2	IDA		Mouse	PMID:9738002
Cellular Component	GO:0005634	nucleus	Tlx2	IDA		Mouse	PMID:9738002
Biological Process	GO:0048484	enteric nervous system development	Tlx2	IMP	MGI:MGI:2448951	Mouse	PMID:9259577
Biological Process	GO:0048839	inner ear development	tlx2	IMP	ZFIN:ZDB-MRPHLNO-150225-2	Zfish	PMID:25568117
Biological Process	GO:0001707	mesoderm formation	Tlx2	IMP	MGI:MGI:1857514	Mouse	PMID:9550720
Biological Process	GO:0050774	negative regulation of dendrite morphogenesis	Tlx2	IDA		Mouse	PMID:9738002
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TLX2	IDA		Human	PMID:10869550

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern