Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMBIM1
  • Mouse genes Tmbim1
  • Rat genes Tmbim1
  • Zfish genes tmbim1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmbim1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005123	death receptor binding	TMBIM1	IDA		Human	PMID:21107705
Molecular Function	GO:0005515	protein binding	TMBIM1	IPI	UniProtKB:P20138	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM1	IPI	UniProtKB:Q13323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM1	IPI	UniProtKB:Q14973	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM1	IPI	UniProtKB:Q6P531	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM1	IPI	UniProtKB:Q7Z5B4-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM1	IPI	UniProtKB:Q8NCR0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM1	IPI	UniProtKB:Q9HC23	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM1	IPI	UniProtKB:Q9NWH2	Human	PMID:32296183
Cellular Component	GO:0010008	endosome membrane	TMBIM1	IDA		Human	PMID:16607040
Cellular Component	GO:0070062	extracellular exosome	TMBIM1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	TMBIM1	HDA		Human	PMID:23533145
Cellular Component	GO:0005794	Golgi apparatus	TMBIM1	IDA		Human	PMID:21107705
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	TMBIM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005765	lysosomal membrane	TMBIM1	IDA		Human	PMID:16607040
Cellular Component	GO:0005765	lysosomal membrane	TMBIM1	HDA		Human	PMID:17897319
Biological Process	GO:0043086	negative regulation of catalytic activity	Tmbim1	IMP		Mouse	MGI:MGI:5572875|PMID:16636500
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TMBIM1	IMP		Human	PMID:21107705
Biological Process	GO:1902045	negative regulation of Fas signaling pathway	TMBIM1	IMP		Human	PMID:21107705
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	TMBIM1	IMP		Human	PMID:21107705
Biological Process	GO:2000504	positive regulation of blood vessel remodeling	Tmbim1	IMP		Mouse	MGI:MGI:5572875|PMID:16636500

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern