Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMBIM6
  • Mouse genes Tmbim6
  • Rat genes Tmbim6
  • Zfish genes tegt
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmbim6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0060698	endoribonuclease inhibitor activity	TMBIM6	IDA		Human	PMID:19328063
Molecular Function	GO:0060698	endoribonuclease inhibitor activity	Tmbim6	IMP		Mouse	MGI:MGI:3840374|PMID:19328063
Molecular Function	GO:0019899	enzyme binding	TMBIM6	IPI	UniProtKB:O75460	Human	PMID:19328063
Molecular Function	GO:0019899	enzyme binding	Tmbim6	IPI	UniProtKB:Q9EQY0	Mouse	MGI:MGI:3840374|PMID:19328063
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q2M2E3	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q96GF1	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P49768	Human	PMID:30559186
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:A0A7P0TAB9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:O00311	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:O15529	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:O75310	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:O75908	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P02724	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P11912	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P15151	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P28335	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P30040	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P30825	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P35372-10	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P36382	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P46695	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P48165	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P48547	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P49863	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q02223	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q14802-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q16322	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q2M2E3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q5SR56	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q6NZ63	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q6UXB8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q6UXG3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q6ZVN8-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q86SS6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q86V24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q86YW5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q86YW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q8IYJ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q8N4V1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q8N6K0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q8N7P3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q8TCZ2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q8TDV0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q8TED1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q96AG4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q96AP7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q96BA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q96DU3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q96GF1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q96GZ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q96HJ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q96MG2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9BRK0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9BSE4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9BVT8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9BYJ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9H400	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9HD20-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9NQG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9NTQ9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9NX52-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9NY72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9Y320	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9Y3P8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9Y666-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q9Y6X5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:P10415	Human	PMID:9660918
Molecular Function	GO:0005515	protein binding	TMBIM6	IPI	UniProtKB:Q07817-1	Human	PMID:9660918
Molecular Function	GO:0031625	ubiquitin protein ligase binding	TMBIM6	IPI	UniProtKB:Q9NZS9	Human	PMID:21068390
Cellular Component	GO:0005737	cytoplasm	TMBIM6	IDA		Human	PMID:9660918
Cellular Component	GO:0005783	endoplasmic reticulum	TMBIM6	IDA		Human	PMID:19328063
Cellular Component	GO:0005783	endoplasmic reticulum	TMBIM6	IDA		Human	PMID:21068390
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TMBIM6	IDA		Human	PMID:9660918
Cellular Component	GO:0016020	membrane	TMBIM6	HDA		Human	PMID:19946888
Cellular Component	GO:0031966	mitochondrial membrane	TMBIM6	IDA		Human	PMID:9660918
Biological Process	GO:0034620	cellular response to unfolded protein	TMBIM6	IDA		Human	PMID:19328063
Biological Process	GO:0034620	cellular response to unfolded protein	Tmbim6	IMP		Mouse	MGI:MGI:3840374|PMID:19328063
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Tmbim6	IDA		Mouse	PMID:22240901
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Tmbim6	IDA		Mouse	PMID:15304216
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Tmbim6	IMP	MGI:MGI:3052422	Mouse	PMID:15304216
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Tmbim6	IDA		Mouse	PMID:15304216
Biological Process	GO:0030324	lung development	Tmbim6	IEP		Rat	PMID:10198159|RGD:2291962
Biological Process	GO:0043066	negative regulation of apoptotic process	TMBIM6	IGI	UniProtKB:Q07812	Human	PMID:9660918
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	TMBIM6	IDA		Human	PMID:21075086
Biological Process	GO:0010523	negative regulation of calcium ion transport into cytosol	TMBIM6	IDA		Human	PMID:26582200
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	TMBIM6	IDA		Human	PMID:21075086
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Tmbim6	IGI	MGI:MGI:1913418	Mouse	PMID:22240901
Biological Process	GO:0060702	negative regulation of endoribonuclease activity	TMBIM6	IDA		Human	PMID:19328063
Biological Process	GO:0060702	negative regulation of endoribonuclease activity	Tmbim6	IMP		Mouse	MGI:MGI:3840374|PMID:19328063
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	TMBIM6	IDA		Human	PMID:21075086
Biological Process	GO:0002638	negative regulation of immunoglobulin production	Tmbim6	IMP		Mouse	MGI:MGI:3840374|PMID:19328063
Biological Process	GO:0032091	negative regulation of protein binding	TMBIM6	IDA		Human	PMID:19328063
Biological Process	GO:0033119	negative regulation of RNA splicing	TMBIM6	IDA		Human	PMID:19328063
Biological Process	GO:0033119	negative regulation of RNA splicing	Tmbim6	IMP		Mouse	MGI:MGI:3840374|PMID:19328063
Biological Process	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	Tmbim6	IMP		Mouse	MGI:MGI:3840374|PMID:19328063
Biological Process	GO:0036483	neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Tmbim6	IMP	MGI:MGI:3052422	Mouse	PMID:15304216
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Tmbim6	IMP		Mouse	MGI:MGI:5619465|PMID:21075086
Biological Process	GO:1902065	response to L-glutamate	TMBIM6	IDA		Human	PMID:21075086
Biological Process	GO:0007283	spermatogenesis	Tmbim6	IEP		Rat	PMID:8012111|RGD:730005

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern