Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMC1
  • Mouse genes Tmc1
  • Rat genes Tmc1
  • Zfish genes tmc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	Tmc1	IMP	MGI:MGI:1856845	Mouse	PMID:24981230
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	Tmc1	IGI	MGI:MGI:2151017	Mouse	PMID:24981230
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	Tmc1	IMP	MGI:MGI:5427097	Mouse	PMID:24981230
Molecular Function	GO:0005515	protein binding	Tmc1	IPI	UniProtKB:A1Y9I9	Mouse	MGI:MGI:6100205|PMID:28504928
Molecular Function	GO:0005515	protein binding	Tmc1	IPI	UniProtKB:A1Y9I9	Mouse	MGI:MGI:6119970|PMID:28534737
Molecular Function	GO:0005515	protein binding	Tmc1	IPI	UniProtKB:Q99PJ1	Mouse	MGI:MGI:5604056|PMID:25114259
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Tmc1	IGI	MGI:MGI:2151017	Mouse	PMID:23871232
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Tmc1	IMP	MGI:MGI:5427097	Mouse	PMID:23871232
Cellular Component	GO:0009897	external side of plasma membrane	Tmc1	IDA		Mouse	PMID:16455951
Cellular Component	GO:0032421	stereocilium bundle	tmc1	IDA		Zfish	PMID:28534737|ZFIN:ZDB-PUB-170524-6
Cellular Component	GO:0032426	stereocilium tip	Tmc1	IDA		Mouse	PMID:22105175
Biological Process	GO:0060117	auditory receptor cell development	Tmc1	IMP	MGI:MGI:5427097	Mouse	PMID:22105175
Biological Process	GO:0070588	calcium ion transmembrane transport	Tmc1	IGI	MGI:MGI:2151017	Mouse	PMID:23871232
Biological Process	GO:0070588	calcium ion transmembrane transport	Tmc1	IMP	MGI:MGI:5427097	Mouse	PMID:23871232
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	Tmc1	IGI	MGI:MGI:2151017	Mouse	PMID:22105175
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	Tmc1	IMP	MGI:MGI:5427097	Mouse	PMID:22105175
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	Tmc1	IMP		Mouse	PMID:23871232
Biological Process	GO:1903169	regulation of calcium ion transmembrane transport	Tmc1	IMP	MGI:MGI:5427097	Mouse	PMID:24981230
Biological Process	GO:1903169	regulation of calcium ion transmembrane transport	Tmc1	IGI	MGI:MGI:2151017	Mouse	PMID:24981230
Biological Process	GO:1903169	regulation of calcium ion transmembrane transport	Tmc1	IMP	MGI:MGI:1856845	Mouse	PMID:24981230
Biological Process	GO:0007605	sensory perception of sound	Tmc1	IMP	MGI:MGI:1856845	Mouse	MGI:MGI:48774
Biological Process	GO:0060005	vestibular reflex	Tmc1	IGI	MGI:MGI:2151017	Mouse	PMID:22105175
Biological Process	GO:0060005	vestibular reflex	Tmc1	IGI	MGI:MGI:2151017	Mouse	PMID:24981230
Biological Process	GO:0060005	vestibular reflex	Tmc1	IMP	MGI:MGI:1856845	Mouse	PMID:24981230
Biological Process	GO:0060005	vestibular reflex	Tmc1	IMP	MGI:MGI:5427097	Mouse	PMID:24981230

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern