Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMC2
  • Mouse genes Tmc2
  • Rat genes Tmc2
  • Zfish genes tmc2a,tmc2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	Tmc2	IGI	MGI:MGI:2151016	Mouse	PMID:24981230
Molecular Function	GO:0005515	protein binding	Tmc2	IPI	UniProtKB:Q99PJ1	Mouse	MGI:MGI:5604056|PMID:25114259
Molecular Function	GO:0005515	protein binding	Tmc2	IPI	UniProtKB:A1Y9I9	Mouse	MGI:MGI:6100205|PMID:28504928
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Tmc2	IGI	MGI:MGI:2151016	Mouse	PMID:23871232
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Tmc2	IMP	MGI:MGI:5427099	Mouse	PMID:23871232
Cellular Component	GO:0032426	stereocilium tip	Tmc2	IDA		Mouse	PMID:22105175
Biological Process	GO:0070588	calcium ion transmembrane transport	Tmc2	IMP	MGI:MGI:5427099	Mouse	PMID:23871232
Biological Process	GO:0070588	calcium ion transmembrane transport	Tmc2	IGI	MGI:MGI:2151016	Mouse	PMID:23871232
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	TMC2	IMP		Human	PMID:11850618
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	Tmc2	IGI	MGI:MGI:2151016	Mouse	PMID:22105175
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	tmc2b	IMP	ZFIN:ZDB-GENO-190604-1	Zfish	PMID:29269857
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	tmc2b	IGI	ZFIN:ZDB-GENO-190604-15	Zfish	PMID:29269857
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	tmc2a	IGI	ZFIN:ZDB-GENO-190604-15	Zfish	PMID:29269857
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	tmc2a	IGI	ZFIN:ZDB-GENO-150116-4	Zfish	PMID:25114259
Biological Process	GO:0048839	inner ear development	tmc2b	IEP		Zfish	PMID:25114259|ZFIN:ZDB-PUB-140813-4
Biological Process	GO:0042472	inner ear morphogenesis	tmc2b	IEP		Zfish	PMID:25114259|ZFIN:ZDB-PUB-140813-4
Biological Process	GO:0048884	neuromast development	tmc2b	IEP		Zfish	PMID:25114259|ZFIN:ZDB-PUB-140813-4
Biological Process	GO:1903169	regulation of calcium ion transmembrane transport	Tmc2	IGI	MGI:MGI:2151016	Mouse	PMID:24981230
Biological Process	GO:0060005	vestibular reflex	Tmc2	IGI	MGI:MGI:2151016	Mouse	PMID:24981230
Biological Process	GO:0060005	vestibular reflex	Tmc2	IGI	MGI:MGI:2151016	Mouse	PMID:22105175

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern