Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMC8
  • Mouse genes Tmc8
  • Rat genes Tmc8
  • Zfish genes tmc8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmc8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TMC8	IPI	UniProtKB:P06927	Human	PMID:18158319
Molecular Function	GO:0005515	protein binding	TMC8	IPI	UniProtKB:Q9Y6M5	Human	PMID:18158319
Molecular Function	GO:0005515	protein binding	TMC8	IPI	UniProtKB:Q99828	Human	PMID:30068544
Molecular Function	GO:0140311	protein sequestering activity	TMC8	IDA		Human	PMID:23429285
Molecular Function	GO:0043120	tumor necrosis factor binding	TMC8	IPI	UniProtKB:Q15628	Human	PMID:23429285
Cellular Component	GO:0005737	cytoplasm	TMC8	IDA		Human	PMID:12426567
Cellular Component	GO:0005783	endoplasmic reticulum	TMC8	IDA		Human	PMID:12426567
Cellular Component	GO:0005783	endoplasmic reticulum	TMC8	IDA		Human	PMID:18158319
Cellular Component	GO:0070062	extracellular exosome	TMC8	HDA		Human	PMID:20458337
Cellular Component	GO:0005615	extracellular space	TMC8	HDA		Human	PMID:22664934
Cellular Component	GO:0005794	Golgi apparatus	TMC8	IDA		Human	PMID:18158319
Cellular Component	GO:0031965	nuclear membrane	TMC8	IDA		Human	PMID:18158319
Biological Process	GO:0006882	intracellular zinc ion homeostasis	TMC8	IDA		Human	PMID:18158319
Biological Process	GO:0032091	negative regulation of protein binding	TMC8	IDA		Human	PMID:23429285
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	TMC8	IDA		Human	PMID:23429285
Biological Process	GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	TMC8	IDA		Human	PMID:23429285

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern