Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMED2
  • Mouse genes Tmed2
  • Rat genes Tmed2
  • Zfish genes tmed2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmed2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005109	frizzled binding	Tmed2	IPI	PR:Q9JIP6	Mouse	PMID:35353806
Molecular Function	GO:0005515	protein binding	TMED2	IPI	UniProtKB:P49755	Human	PMID:10359607
Molecular Function	GO:0005515	protein binding	TMED2	IPI	UniProtKB:P49755	Human	PMID:12237308
Molecular Function	GO:0005515	protein binding	TMED2	IPI	UniProtKB:P49755	Human	PMID:16641999
Molecular Function	GO:0005515	protein binding	TMED2	IPI	UniProtKB:P55085	Human	PMID:17693410
Molecular Function	GO:0005515	protein binding	TMED2	IPI	UniProtKB:P49755	Human	PMID:18287528
Molecular Function	GO:0005515	protein binding	TMED2	IPI	UniProtKB:P41180	Human	PMID:20361938
Molecular Function	GO:0005515	protein binding	TMED2	IPI	UniProtKB:O35587	Human	PMID:20427317
Molecular Function	GO:0005515	protein binding	TMED2	IPI	UniProtKB:P13987	Human	PMID:20427317
Molecular Function	GO:0005515	protein binding	TMED2	IPI	UniProtKB:P49755	Human	PMID:20427317
Molecular Function	GO:0005515	protein binding	TMED2	IPI	UniProtKB:P55085	Human	PMID:21219331
Molecular Function	GO:0005515	protein binding	Tmed2	IPI	PR:O88312	Mouse	PMID:31040128
Molecular Function	GO:0005515	protein binding	Tmed2	IPI	UniProtKB:O35254	Rat	PMID:11739402|RGD:2317249
Molecular Function	GO:0005515	protein binding	Tmed2	IPI	UniProtKB:Q9R064	Rat	PMID:11739402|RGD:2317249
Molecular Function	GO:0005515	protein binding	Tmed2	IPI	UniProtKB:Q63645	Rat	PMID:17693410|RGD:8554006
Molecular Function	GO:0005119	smoothened binding	Tmed2	IPI	PR:P56726	Mouse	PMID:35353806
Cellular Component	GO:0030137	COPI-coated vesicle	Tmed2	IDA		Rat	PMID:10214941|RGD:2317280
Cellular Component	GO:0005783	endoplasmic reticulum	TMED2	IDA		Human	PMID:12237308
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Tmed2	IDA		Mouse	PMID:30236446
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	TMED2	IDA		Human	PMID:12237308
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	Tmed2	IDA		Mouse	PMID:30236446
Cellular Component	GO:0005794	Golgi apparatus	TMED2	IDA		Human	PMID:12237308
Cellular Component	GO:0005794	Golgi apparatus	Tmed2	IDA		Mouse	PMID:35353806
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	TMED2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Tmed2	IDA		Rat	PMID:8663407|RGD:68840
Cellular Component	GO:0042589	zymogen granule membrane	Tmed2	IDA		Rat	PMID:8663407|RGD:68840
Biological Process	GO:1905069	allantois development	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:30236446
Biological Process	GO:0060670	branching involved in labyrinthine layer morphogenesis	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:30236446
Biological Process	GO:0060717	chorion development	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:30236446
Biological Process	GO:0048598	embryonic morphogenesis	Tmed2	IMP		Mouse	MGI:MGI:4453264|PMID:20178780
Biological Process	GO:0001892	embryonic placenta development	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:20178780
Biological Process	GO:0090158	endoplasmic reticulum membrane organization	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:28797121
Biological Process	GO:0007029	endoplasmic reticulum organization	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:30236446
Biological Process	GO:0007030	Golgi organization	TMED2	IMP		Human	PMID:17693410
Biological Process	GO:0001947	heart looping	Tmed2	IMP	MGI:MGI:4343479	Mouse	PMID:20178780
Biological Process	GO:0001947	heart looping	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:20178780
Biological Process	GO:0001701	in utero embryonic development	Tmed2	IMP	MGI:MGI:4343479	Mouse	PMID:20178780
Biological Process	GO:0001701	in utero embryonic development	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:20178780
Biological Process	GO:0006954	inflammatory response	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:31040128
Biological Process	GO:0006886	intracellular protein transport	TMED2	IDA		Human	PMID:20427317
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Tmed2	IMP		Mouse	MGI:MGI:4453264|PMID:20178780
Biological Process	GO:0072595	maintenance of protein localization in organelle	Tmed2	IMP		Mouse	PMID:35353806
Biological Process	GO:0001893	maternal placenta development	Tmed2	IMP		Mouse	MGI:MGI:4453264|PMID:20178780
Biological Process	GO:0035264	multicellular organism growth	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:20178780
Biological Process	GO:0035264	multicellular organism growth	Tmed2	IMP	MGI:MGI:4343479	Mouse	PMID:20178780
Biological Process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:28797121
Biological Process	GO:0034260	negative regulation of GTPase activity	TMED2	IDA		Human	PMID:10761932
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	Tmed2	IMP		Mouse	PMID:35353806
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Tmed2	IMP		Mouse	PMID:35353806
Biological Process	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	Tmed2	IMP		Mouse	PMID:35353806
Biological Process	GO:0001843	neural tube closure	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:20178780
Biological Process	GO:0036499	PERK-mediated unfolded protein response	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:28797121
Biological Process	GO:0010628	positive regulation of gene expression	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:20178780
Biological Process	GO:0036342	post-anal tail morphogenesis	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:20178780
Biological Process	GO:0036342	post-anal tail morphogenesis	Tmed2	IMP	MGI:MGI:4343479	Mouse	PMID:20178780
Biological Process	GO:0008104	protein localization	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:30236446
Biological Process	GO:0072659	protein localization to plasma membrane	TMED2	IDA		Human	PMID:20361938
Biological Process	GO:0009306	protein secretion	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:31040128
Biological Process	GO:2000638	regulation of SREBP signaling pathway	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:28797121
Biological Process	GO:0032525	somite rostral/caudal axis specification	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:20178780
Biological Process	GO:0001756	somitogenesis	Tmed2	IMP	MGI:MGI:4456438	Mouse	PMID:20178780

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern