Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMEM106B
  • Mouse genes Tmem106b
  • Rat genes Tmem106b
  • Zfish genes tmem106ba,tmem106bb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmem106b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051117	ATPase binding	TMEM106B	IPI	UniProtKB:Q15904	Human	PMID:28728022
Molecular Function	GO:0051117	ATPase binding	Tmem106b	IPI	UniProtKB:Q15904	Mouse	PMID:28728022
Molecular Function	GO:0005515	protein binding	TMEM106B	IPI	UniProtKB:Q96JE9	Human	PMID:24357581
Molecular Function	GO:0005515	protein binding	TMEM106B	IPI	UniProtKB:Q9BVX2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM106B	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Tmem106b	IPI	UniProtKB:Q63560	Rat	PMID:24357581|RGD:8693363
Cellular Component	GO:0005768	endosome	TMEM106B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005765	lysosomal membrane	TMEM106B	IDA		Human	PMID:24357581
Cellular Component	GO:0005764	lysosome	TMEM106B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	Tmem106b	IDA		Mouse	MGI:MGI:5701557|PMID:26370502
Cellular Component	GO:0005764	lysosome	Tmem106b	IDA		Mouse	PMID:25066864
Biological Process	GO:0048813	dendrite morphogenesis	TMEM106B	IMP		Human	PMID:24357581
Biological Process	GO:0007042	lysosomal lumen acidification	Tmem106b	IMP	MGI:MGI:5319917	Mouse	PMID:28728022
Biological Process	GO:1905146	lysosomal protein catabolic process	Tmem106b	IMP	MGI:MGI:5319917	Mouse	PMID:28728022
Biological Process	GO:0007041	lysosomal transport	Tmem106b	IMP		Mouse	PMID:25066864
Biological Process	GO:0032418	lysosome localization	TMEM106B	IMP		Human	PMID:24357581
Biological Process	GO:0007040	lysosome organization	Tmem106b	IMP		Mouse	PMID:25066864
Biological Process	GO:0070050	neuron cellular homeostasis	Tmem106b	IMP	MGI:MGI:5319917	Mouse	PMID:28728022
Biological Process	GO:1900006	positive regulation of dendrite development	Tmem106b	IMP		Mouse	PMID:25066864
Biological Process	GO:0051345	positive regulation of hydrolase activity	Tmem106b	IMP	MGI:MGI:5319917	Mouse	PMID:28728022
Biological Process	GO:1905671	regulation of lysosome organization	Tmem106b	IMP	MGI:MGI:5319917	Mouse	PMID:28728022

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern