Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMEM53
  • Mouse genes Tmem53
  • Rat genes Tmem53
  • Zfish genes tmem53
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmem53

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Cellular Component	GO:0031965	nuclear membrane	TMEM53	IDA		Human	PMID:33824347
Cellular Component	GO:0005640	nuclear outer membrane	Tmem53	IDA		Mouse	MGI:MGI:7310194|PMID:20091084
Cellular Component	GO:0005634	nucleus	TMEM53	HDA		Human	PMID:21630459
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	TMEM53	IMP		Human	PMID:33824347
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Tmem53	IMP		Mouse	MGI:MGI:6713651|PMID:33824347
Biological Process	GO:0030279	negative regulation of ossification	TMEM53	IMP		Human	PMID:33824347
Biological Process	GO:0030279	negative regulation of ossification	Tmem53	IMP		Mouse	MGI:MGI:6713651|PMID:33824347
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Tmem53	IMP		Mouse	MGI:MGI:6713651|PMID:33824347
Biological Process	GO:0046822	regulation of nucleocytoplasmic transport	TMEM53	IMP		Human	PMID:33824347
Biological Process	GO:0046822	regulation of nucleocytoplasmic transport	Tmem53	IMP		Mouse	MGI:MGI:6713651|PMID:33824347

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern