Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMEM64
  • Mouse genes Tmem64
  • Rat genes Tmem64
  • Zfish genes tmem64
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmem64

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Tmem64	IPI	PR:P27773	Mouse	PMID:23395171
Molecular Function	GO:0005515	protein binding	Tmem64	IPI	PR:O55143	Mouse	PMID:23395171
Cellular Component	GO:0005783	endoplasmic reticulum	Tmem64	IDA		Mouse	PMID:23395171
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Tmem64	IMP		Mouse	MGI:MGI:5643786|PMID:25979161
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Tmem64	IMP		Mouse	MGI:MGI:5643786|PMID:25979161
Biological Process	GO:0030316	osteoclast differentiation	Tmem64	IMP	MGI:MGI:3880885	Mouse	PMID:23395171
Biological Process	GO:0045780	positive regulation of bone resorption	Tmem64	IMP	MGI:MGI:3880885	Mouse	PMID:23395171
Biological Process	GO:0045600	positive regulation of fat cell differentiation	Tmem64	IMP		Mouse	MGI:MGI:5643786|PMID:25979161
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Tmem64	IMP	MGI:MGI:3880885	Mouse	PMID:23395171
Biological Process	GO:0043462	regulation of ATP-dependent activity	Tmem64	IMP	MGI:MGI:3880885	Mouse	PMID:23395171
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	Tmem64	IMP	MGI:MGI:3880885	Mouse	PMID:23395171

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern