Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMEM74
  • Mouse genes Tmem74
  • Rat genes Tmem74
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmem74

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TMEM74	IPI	UniProtKB:Q969F0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TMEM74	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM74	IPI	UniProtKB:Q5J8X5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM74	IPI	UniProtKB:Q69YG0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TMEM74	IPI	UniProtKB:Q9H400	Human	PMID:32296183
Molecular Function	GO:0044325	transmembrane transporter binding	Tmem74	IPI	PR:O88704	Mouse	PMID:30886335
Cellular Component	GO:0005886	plasma membrane	Tmem74	IDA		Mouse	PMID:30886335
Biological Process	GO:0051867	general adaptation syndrome, behavioral process	Tmem74	IDA		Mouse	PMID:30886335
Biological Process	GO:0051867	general adaptation syndrome, behavioral process	Tmem74	IMP	MGI:MGI:6690870	Mouse	PMID:30886335
Biological Process	GO:0051867	general adaptation syndrome, behavioral process	Tmem74	IMP		Mouse	PMID:30886335
Biological Process	GO:0016236	macroautophagy	TMEM74	IMP		Human	PMID:18294959
Biological Process	GO:2001257	regulation of cation channel activity	Tmem74	IMP	MGI:MGI:6690870	Mouse	PMID:30886335
Biological Process	GO:2001257	regulation of cation channel activity	Tmem74	IDA		Mouse	PMID:30886335

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern