Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMPRSS6
  • Mouse genes Tmprss6
  • Rat genes Tmprss6
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmprss6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TMPRSS6	IPI	UniProtKB:Q6ZVN8	Human	PMID:19357398
Cellular Component	GO:0005615	extracellular space	TMPRSS6	IDA		Human	PMID:25156943
Cellular Component	GO:0005886	plasma membrane	TMPRSS6	IDA		Human	PMID:19357398
Cellular Component	GO:0005886	plasma membrane	Tmprss6	IDA		Mouse	PMID:12744720
Biological Process	GO:0030509	BMP signaling pathway	Tmprss6	IGI	MGI:MGI:1916835	Mouse	PMID:19751239
Biological Process	GO:0030509	BMP signaling pathway	Tmprss6	IGI	MGI:MGI:1321394	Mouse	PMID:19751239
Biological Process	GO:0030509	BMP signaling pathway	Tmprss6	IGI	MGI:MGI:88177	Mouse	PMID:19751239
Biological Process	GO:0030509	BMP signaling pathway	Tmprss6	IGI	MGI:MGI:88180	Mouse	PMID:19751239
Biological Process	GO:0006879	intracellular iron ion homeostasis	Tmprss6	IMP		Mouse	MGI:MGI:5644209|PMID:25860887
Biological Process	GO:0033619	membrane protein proteolysis	TMPRSS6	IMP		Human	PMID:25156943
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	TMPRSS6	IMP		Human	PMID:18408718
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Tmprss6	IMP	MGI:MGI:3776631	Mouse	PMID:19751239
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Tmprss6	IGI	MGI:MGI:88180	Mouse	PMID:19751239
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Tmprss6	IGI	MGI:MGI:1321394	Mouse	PMID:19751239
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Tmprss6	IGI	MGI:MGI:1916835	Mouse	PMID:19751239
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Tmprss6	IGI	MGI:MGI:88177	Mouse	PMID:19751239
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	TMPRSS6	IMP		Human	PMID:25156943
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tmprss6	IMP		Mouse	MGI:MGI:5644209|PMID:25860887
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tmprss6	IMP		Mouse	MGI:MGI:5644209|PMID:25860887
Biological Process	GO:0097264	self proteolysis	TMPRSS6	IMP		Human	PMID:25156943

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern