Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TNFAIP3
  • Mouse genes Tnfaip3
  • Rat genes Tnfaip3
  • Zfish genes tnfaip3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnfaip3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	TNFAIP3	IDA		Human	PMID:15258597
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	TNFAIP3	IMP		Human	PMID:15258597
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	TNFAIP3	IDA		Human	PMID:23827681
Molecular Function	GO:0042802	identical protein binding	TNFAIP3	IPI	UniProtKB:P21580	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	TNFAIP3	IPI	UniProtKB:P21580	Human	PMID:25502805
Molecular Function	GO:0042802	identical protein binding	TNFAIP3	IPI	UniProtKB:P21580	Human	PMID:30561431
Molecular Function	GO:0042802	identical protein binding	TNFAIP3	IPI	UniProtKB:P21580	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	TNFAIP3	IPI	UniProtKB:P21580	Human	PMID:32296183
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	TNFAIP3	EXP		Human	PMID:14748687
Molecular Function	GO:0019900	kinase binding	Tnfaip3	IDA		Mouse	MGI:MGI:3777503|PMID:18342009
Molecular Function	GO:0002020	protease binding	TNFAIP3	IPI	UniProtKB:Q9UDY8	Human	PMID:18223652
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q9Y4K3	Human	PMID:11463333
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q8IUC6	Human	PMID:15142865
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q8NFZ5	Human	PMID:15169888
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q9Y3C5	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q15025	Human	PMID:15474016
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q86VP1	Human	PMID:15474016
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q8NFZ5	Human	PMID:15474016
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q9Y6K9	Human	PMID:15474016
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q14790	Human	PMID:19060883
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q9Y3C5	Human	PMID:19131965
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q92985	Human	PMID:20392859
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q15025	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q9Y6K9	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q9Y6K9	Human	PMID:23032186
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:P36406	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q12933	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q15025	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q96B67	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q96KP6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q12933	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q15025	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q86VP1	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q8NFZ5	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q9Y6K9	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q12933	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q15025	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:O95995	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:P36406	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:P54725	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q12933	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q15025	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q4G0R1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q86VP1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q96B67	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:Q9NWF9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNFAIP3	IPI	UniProtKB:P68510	Human	PMID:9299557
Molecular Function	GO:0005515	protein binding	Tnfaip3	IPI	UniProtKB:Q2TBA3	Mouse	MGI:MGI:4943389|PMID:18223652
Molecular Function	GO:0005515	protein binding	Tnfaip3	IPI	UniProtKB:Q3UKC1	Mouse	MGI:MGI:3774717|PMID:18239685
Molecular Function	GO:0005515	protein binding	Tnfaip3	IPI	UniProtKB:Q9WUU8	Mouse	MGI:MGI:1891487|PMID:10385526
Molecular Function	GO:0005515	protein binding	Tnfaip3	IPI	UniProtKB:Q61168	Mouse	MGI:MGI:6391873|PMID:22733818
Molecular Function	GO:0005515	protein binding	Tnfaip3	IDA		Mouse	MGI:MGI:6391873|PMID:22733818
Molecular Function	GO:0005515	protein binding	Tnfaip3	IPI	UniProtKB:Q9WUU8	Mouse	MGI:MGI:5430899|PMID:12586352
Molecular Function	GO:0005515	protein binding	Tnfaip3	IPI	UniProtKB:P39429	Mouse	MGI:MGI:5291889|PMID:21765415
Molecular Function	GO:0005515	protein binding	Tnfaip3	IPI	UniProtKB:Q9WUU8	Mouse	MGI:MGI:3835211|PMID:19060883
Molecular Function	GO:0005515	protein binding	Tnfaip3	IPI	UniProtKB:P01375	Mouse	MGI:MGI:5706670|PMID:26649818
Molecular Function	GO:0005515	protein binding	Tnfaip3	IPI	UniProtKB:Q9CYZ8	Mouse	MGI:MGI:4455093|PMID:20211142
Molecular Function	GO:0005515	protein binding	Tnfaip3	IPI	UniProtKB:P39429	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Tnfaip3	IPI	PR:Q99JG7	Mouse	PMID:11390377
Molecular Function	GO:0043621	protein self-association	TNFAIP3	IDA		Human	PMID:15474016
Molecular Function	GO:0043621	protein self-association	TNFAIP3	IDA		Human	PMID:8797804
Molecular Function	GO:0043130	ubiquitin binding	TNFAIP3	IPI	UniProtKB:P0CG48	Human	PMID:19285159
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TNFAIP3	IDA		Human	PMID:15258597
Cellular Component	GO:0005737	cytoplasm	Tnfaip3	IDA		Mouse	PMID:10385526
Cellular Component	GO:0070062	extracellular exosome	TNFAIP3	HDA		Human	PMID:20458337
Cellular Component	GO:0005634	nucleus	TNFAIP3	IDA		Human	PMID:11463333
Biological Process	GO:0001922	B-1 B cell homeostasis	Tnfaip3	IMP		Mouse	MGI:MGI:4946158|PMID:21088135
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Tnfaip3	IMP		Mouse	MGI:MGI:5490396|PMID:23609450
Biological Process	GO:0071222	cellular response to lipopolysaccharide	TNFAIP3	IDA		Human	PMID:19912257
Biological Process	GO:0071222	cellular response to lipopolysaccharide	TNFAIP3	IDA		Human	PMID:21127049
Biological Process	GO:0071222	cellular response to lipopolysaccharide	TNFAIP3	IDA		Human	PMID:21220427
Biological Process	GO:1904888	cranial skeletal system development	tnfaip3	IMP	ZFIN:ZDB-MRPHLNO-100225-22	Zfish	PMID:28450118
Biological Process	GO:0072666	establishment of protein localization to vacuole	Tnfaip3	IDA		Mouse	PMID:18952128
Biological Process	GO:0050869	negative regulation of B cell activation	Tnfaip3	IDA		Mouse	MGI:MGI:4946158|PMID:21088135
Biological Process	GO:2000349	negative regulation of CD40 signaling pathway	TNFAIP3	IMP		Human	PMID:12885753
Biological Process	GO:0060548	negative regulation of cell death	Tnfaip3	IMP		Mouse	MGI:MGI:3055167|PMID:11009421
Biological Process	GO:0002677	negative regulation of chronic inflammatory response	Tnfaip3	IMP		Mouse	MGI:MGI:3763997|PMID:18006655
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	Tnfaip3	IDA		Mouse	MGI:MGI:4943408|PMID:15962316
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	TNFAIP3	IDA		Human	PMID:12885753
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TNFAIP3	IDA		Human	PMID:12167698
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	TNFAIP3	IDA		Human	PMID:11463333
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	TNFAIP3	IDA		Human	PMID:15258597
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	TNFAIP3	IDA		Human	PMID:21127049
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	Tnfaip3	IMP		Mouse	MGI:MGI:3777503|PMID:18342009
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	Tnfaip3	IMP		Mouse	MGI:MGI:4946158|PMID:21088135
Biological Process	GO:0050728	negative regulation of inflammatory response	Tnfaip3	IDA		Mouse	MGI:MGI:5490396|PMID:23609450
Biological Process	GO:0050728	negative regulation of inflammatory response	Tnfaip3	IMP		Mouse	MGI:MGI:4946158|PMID:21088135
Biological Process	GO:0045824	negative regulation of innate immune response	Tnfaip3	IMP		Mouse	MGI:MGI:5490396|PMID:23609450
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	TNFAIP3	IMP		Human	PMID:28094437
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	Tnfaip3	IMP		Mouse	MGI:MGI:3763997|PMID:18006655
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	Tnfaip3	IMP		Mouse	MGI:MGI:3777503|PMID:18342009
Biological Process	GO:0032703	negative regulation of interleukin-2 production	TNFAIP3	IMP		Human	PMID:18223652
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Tnfaip3	IMP		Mouse	MGI:MGI:3763997|PMID:18006655
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Tnfaip3	IMP		Mouse	MGI:MGI:3777503|PMID:18342009
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Tnfaip3	IMP		Mouse	MGI:MGI:4946158|PMID:21088135
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	TNFAIP3	IDA		Human	PMID:18223652
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	tnfaip3	IMP	ZFIN:ZDB-GENO-220511-6	Zfish	PMID:33154446
Biological Process	GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	Tnfaip3	IMP		Mouse	MGI:MGI:3777503|PMID:18342009
Biological Process	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	Tnfaip3	IDA		Mouse	MGI:MGI:3777503|PMID:18342009
Biological Process	GO:0031397	negative regulation of protein ubiquitination	TNFAIP3	IDA		Human	PMID:20392859
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	TNFAIP3	IDA		Human	PMID:16816117
Biological Process	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	TNFAIP3	IDA		Human	PMID:15474016
Biological Process	GO:0034148	negative regulation of toll-like receptor 5 signaling pathway	Tnfaip3	IDA		Mouse	MGI:MGI:4943853|PMID:19912257
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Tnfaip3	IMP		Mouse	MGI:MGI:4946158|PMID:21088135
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	Tnfaip3	IDA		Mouse	MGI:MGI:4943408|PMID:15962316
Biological Process	GO:0045732	positive regulation of protein catabolic process	TNFAIP3	IDA		Human	PMID:21127049
Biological Process	GO:0045732	positive regulation of protein catabolic process	Tnfaip3	IDA		Mouse	PMID:18952128
Biological Process	GO:0016579	protein deubiquitination	Tnfaip3	IDA		Mouse	MGI:MGI:3777503|PMID:18342009
Biological Process	GO:0035871	protein K11-linked deubiquitination	TNFAIP3	IDA		Human	PMID:23827681
Biological Process	GO:0071108	protein K48-linked deubiquitination	TNFAIP3	IDA		Human	PMID:23827681
Biological Process	GO:0070936	protein K48-linked ubiquitination	TNFAIP3	IDA		Human	PMID:15258597
Biological Process	GO:0070536	protein K63-linked deubiquitination	TNFAIP3	IDA		Human	PMID:15258597
Biological Process	GO:0070536	protein K63-linked deubiquitination	Tnfaip3	IDA		Mouse	PMID:24012418
Biological Process	GO:0002634	regulation of germinal center formation	Tnfaip3	IMP		Mouse	MGI:MGI:4946158|PMID:21088135
Biological Process	GO:0002237	response to molecule of bacterial origin	TNFAIP3	IDA		Human	PMID:19912257
Biological Process	GO:0002237	response to molecule of bacterial origin	Tnfaip3	IDA		Mouse	MGI:MGI:4943853|PMID:19912257
Biological Process	GO:0032495	response to muramyl dipeptide	Tnfaip3	IMP		Mouse	MGI:MGI:3777503|PMID:18342009
Biological Process	GO:0072573	tolerance induction to lipopolysaccharide	TNFAIP3	IMP		Human	PMID:21220427

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern