Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tnfrsf11a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TNFRSF11A
- Mouse genes Tnfrsf11a
- Rat genes Tnfrsf11a
- Zfish genes tnfrsf11a
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnfrsf11a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019955	cytokine binding	TNFRSF11A	IPI	UniProtKB:O35235	Human	PMID:9367155
Molecular Function	GO:0005515	protein binding	TNFRSF11A	IPI	UniProtKB:Q12933	Human	PMID:10075662
Molecular Function	GO:0005515	protein binding	TNFRSF11A	IPI	UniProtKB:Q9UQC2	Human	PMID:15750601
Molecular Function	GO:0005515	protein binding	TNFRSF11A	IPI	UniProtKB:Q9Z1S8	Human	PMID:15750601
Molecular Function	GO:0005515	protein binding	TNFRSF11A	IPI	UniProtKB:O14788:PRO_0000034515	Human	PMID:23333834
Molecular Function	GO:0005515	protein binding	TNFRSF11A	IPI	UniProtKB:Q12933	Human	PMID:29844572
Molecular Function	GO:0005515	protein binding	Tnfrsf11a	IPI	UniProtKB:O35235-1	Mouse	MGI:MGI:5918211\|PMID:21059944
Molecular Function	GO:0005515	protein binding	Tnfrsf11a	IPI	UniProtKB:Q60803\|UniProtKB:Q9Z1R2	Mouse	MGI:MGI:3688344\|PMID:15102471
Molecular Function	GO:0005515	protein binding	Tnfrsf11a	IPI	UniProtKB:O35235-1	Mouse	MGI:MGI:5917007\|PMID:23039992
Molecular Function	GO:0005515	protein binding	Tnfrsf11a	IPI	UniProtKB:P39429\|UniProtKB:P70196	Mouse	MGI:MGI:1334074\|PMID:10097072
Molecular Function	GO:0004888	transmembrane signaling receptor activity	TNFRSF11A	IDA		Human	PMID:9367155
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	Tnfrsf11a	IMP		Mouse	MGI:MGI:4413614\|PMID:19940926
Cellular Component	GO:0009986	cell surface	Tnfrsf11a	IDA		Mouse	PMID:21844205
Cellular Component	GO:0005737	cytoplasm	Tnfrsf11a	IDA		Rat	PMID:20833686\|RGD:151665823
Cellular Component	GO:0005829	cytosol	TNFRSF11A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	TNFRSF11A	IDA		Human	PMID:9367155
Cellular Component	GO:0005886	plasma membrane	TNFRSF11A	IDA		Human	GO_REF:0000052
Biological Process	GO:0002250	adaptive immune response	TNFRSF11A	IMP		Human	PMID:18606301
Biological Process	GO:0034224	cellular response to zinc ion starvation	Tnfrsf11a	IEP		Rat	PMID:21893222\|RGD:151667428
Biological Process	GO:0060086	circadian temperature homeostasis	Tnfrsf11a	IMP		Mouse	MGI:MGI:4413614\|PMID:19940926
Biological Process	GO:0048535	lymph node development	Tnfrsf11a	IMP	MGI:MGI:1860238	Mouse	PMID:10500098
Biological Process	GO:0060749	mammary gland alveolus development	Tnfrsf11a	IMP	MGI:MGI:2183226	Mouse	PMID:11051546
Biological Process	GO:0007275	multicellular organism development	Tnfrsf11a	IMP	MGI:MGI:1860238	Mouse	PMID:10500098
Biological Process	GO:0072674	multinuclear osteoclast differentiation	Tnfrsf11a	IMP		Mouse	PMID:11805147
Biological Process	GO:0001503	ossification	Tnfrsf11a	IMP	MGI:MGI:1860238	Mouse	PMID:10500098
Biological Process	GO:0030316	osteoclast differentiation	TNFRSF11A	IMP		Human	PMID:18606301
Biological Process	GO:0030316	osteoclast differentiation	Tnfrsf11a	IEP		Rat	PMID:22576626\|RGD:151667429
Biological Process	GO:0045780	positive regulation of bone resorption	Tnfrsf11a	IMP		Mouse	PMID:11805147
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	TNFRSF11A	IDA		Human	PMID:12296995
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Tnfrsf11a	IMP		Mouse	MGI:MGI:4413614\|PMID:19940926
Biological Process	GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	TNFRSF11A	IMP		Human	PMID:18606301
Biological Process	GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion	Tnfrsf11a	IMP		Mouse	MGI:MGI:4413614\|PMID:19940926
Biological Process	GO:0043507	positive regulation of JUN kinase activity	TNFRSF11A	IMP		Human	PMID:12296995
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TNFRSF11A	IMP		Human	PMID:12296995
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TNFRSF11A	IDA		Human	PMID:9367155
Biological Process	GO:0034097	response to cytokine	TNFRSF11A	IMP		Human	PMID:18606301
Biological Process	GO:0045471	response to ethanol	Tnfrsf11a	IEP		Rat	PMID:22576626\|RGD:151667429
Biological Process	GO:0032868	response to insulin	Tnfrsf11a	IEP		Rat	PMID:20818503\|RGD:151667419
Biological Process	GO:0070555	response to interleukin-1	Tnfrsf11a	IMP		Mouse	MGI:MGI:4413614\|PMID:19940926
Biological Process	GO:0032496	response to lipopolysaccharide	Tnfrsf11a	IMP		Mouse	MGI:MGI:4413614\|PMID:19940926
Biological Process	GO:0009612	response to mechanical stimulus	Tnfrsf11a	IEP		Rat	PMID:20833686\|RGD:151665823
Biological Process	GO:0014070	response to organic cyclic compound	Tnfrsf11a	IEP		Rat	PMID:20818503\|RGD:151667419
Biological Process	GO:0009314	response to radiation	Tnfrsf11a	IEP		Rat	PMID:16752412\|RGD:2302322
Biological Process	GO:0034612	response to tumor necrosis factor	Tnfrsf11a	IMP		Mouse	MGI:MGI:4413614\|PMID:19940926
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	TNFRSF11A	IMP		Human	PMID:18606301
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	Tnfrsf11a	IMP		Mouse	MGI:MGI:4413614\|PMID:19940926

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.