Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TNFRSF21
  • Mouse genes Tnfrsf21
  • Rat genes Tnfrsf21
  • Zfish genes tnfrsf21
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnfrsf21

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TNFRSF21	IPI	UniProtKB:P08138	Human	PMID:23559013
Molecular Function	GO:0005515	protein binding	TNFRSF21	IPI	UniProtKB:O43765	Human	PMID:32296183
Cellular Component	GO:0030424	axon	Tnfrsf21	IDA		Mouse	MGI:MGI:3838040|PMID:19225519
Cellular Component	GO:0005737	cytoplasm	Tnfrsf21	IDA		Rat	PMID:25898930|RGD:13781947
Cellular Component	GO:0005886	plasma membrane	TNFRSF21	IDA		Human	PMID:19654028
Cellular Component	GO:0005886	plasma membrane	Tnfrsf21	IDA		Mouse	MGI:MGI:3628730|PMID:12515813
Biological Process	GO:0002250	adaptive immune response	Tnfrsf21	IMP		Mouse	MGI:MGI:2137821|PMID:11485735
Biological Process	GO:0006915	apoptotic process	TNFRSF21	IMP		Human	PMID:22761420
Biological Process	GO:0007413	axonal fasciculation	Tnfrsf21	IMP		Rat	PMID:25898930|RGD:13781947
Biological Process	GO:0001783	B cell apoptotic process	Tnfrsf21	IMP		Mouse	MGI:MGI:3628730|PMID:12515813
Biological Process	GO:0071356	cellular response to tumor necrosis factor	TNFRSF21	IDA		Human	PMID:19654028
Biological Process	GO:0014045	establishment of endothelial blood-brain barrier	tnfrsf21	IGI	ZFIN:ZDB-MRPHLNO-120302-1,ZFIN:ZDB-MRPHLNO-120302-4	Zfish	PMID:22340501
Biological Process	GO:0014045	establishment of endothelial blood-brain barrier	tnfrsf21	IMP	ZFIN:ZDB-MRPHLNO-120302-1	Zfish	PMID:22340501
Biological Process	GO:0006959	humoral immune response	Tnfrsf21	IMP		Mouse	MGI:MGI:2137821|PMID:11485735
Biological Process	GO:0042552	myelination	Tnfrsf21	IMP		Mouse	MGI:MGI:5545972|PMID:21725297
Biological Process	GO:0030889	negative regulation of B cell proliferation	Tnfrsf21	IMP		Mouse	MGI:MGI:3628730|PMID:12515813
Biological Process	GO:0032693	negative regulation of interleukin-10 production	Tnfrsf21	IMP		Mouse	MGI:MGI:2137821|PMID:11485735
Biological Process	GO:0032696	negative regulation of interleukin-13 production	Tnfrsf21	IMP		Mouse	MGI:MGI:2137821|PMID:11485735
Biological Process	GO:0032714	negative regulation of interleukin-5 production	Tnfrsf21	IMP		Mouse	MGI:MGI:2137821|PMID:11485735
Biological Process	GO:0031642	negative regulation of myelination	TNFRSF21	IMP		Human	PMID:21725297
Biological Process	GO:0042130	negative regulation of T cell proliferation	Tnfrsf21	IMP		Mouse	MGI:MGI:2137821|PMID:11485735
Biological Process	GO:0051402	neuron apoptotic process	Tnfrsf21	IMP		Mouse	MGI:MGI:5546316|PMID:23559013
Biological Process	GO:0051402	neuron apoptotic process	Tnfrsf21	IMP		Mouse	MGI:MGI:3838040|PMID:19225519
Biological Process	GO:0097252	oligodendrocyte apoptotic process	Tnfrsf21	IMP		Mouse	MGI:MGI:5545972|PMID:21725297
Biological Process	GO:0048713	regulation of oligodendrocyte differentiation	Tnfrsf21	IMP		Mouse	MGI:MGI:5545972|PMID:21725297
Biological Process	GO:0002040	sprouting angiogenesis	tnfrsf21	IMP	ZFIN:ZDB-MRPHLNO-120302-1	Zfish	PMID:22340501
Biological Process	GO:0002040	sprouting angiogenesis	tnfrsf21	IGI	ZFIN:ZDB-MRPHLNO-120302-1,ZFIN:ZDB-MRPHLNO-120302-4	Zfish	PMID:22340501
Biological Process	GO:0050852	T cell receptor signaling pathway	Tnfrsf21	IMP		Mouse	MGI:MGI:2137821|PMID:11485735

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern