Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TNFRSF4
  • Mouse genes Tnfrsf4
  • Rat genes Tnfrsf4
  • Zfish genes si:ch73-361p23.3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnfrsf4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TNFRSF4	IPI	UniProtKB:P23510	Human	PMID:16905106
Molecular Function	GO:0005515	protein binding	Tnfrsf4	IPI	UniProtKB:P39429	Mouse	MGI:MGI:1101440|PMID:9418902
Molecular Function	GO:0005515	protein binding	Tnfrsf4	IPI	UniProtKB:P39429	Mouse	MGI:MGI:4939821|PMID:21282629
Molecular Function	GO:0005515	protein binding	Tnfrsf4	IPI	UniProtKB:O54926	Mouse	MGI:MGI:3696501|PMID:12478477
Molecular Function	GO:0005515	protein binding	Tnfrsf4	IPI	UniProtKB:P43488	Mouse	MGI:MGI:74350|PMID:7749983
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	Tnfrsf4	IPI	UniProtKB:P43488	Mouse	PMID:14635034
Cellular Component	GO:0009986	cell surface	Tnfrsf4	IMP		Rat	PMID:2828930|RGD:730097
Cellular Component	GO:0009897	external side of plasma membrane	Tnfrsf4	IDA		Mouse	PMID:19008373
Cellular Component	GO:0009897	external side of plasma membrane	Tnfrsf4	IDA		Mouse	PMID:16301745
Cellular Component	GO:0005886	plasma membrane	Tnfrsf4	IDA		Mouse	PMID:10586044
Biological Process	GO:0006968	cellular defense response	Tnfrsf4	IMP	MGI:MGI:1859871	Mouse	PMID:10586044
Biological Process	GO:0006954	inflammatory response	Tnfrsf4	IPI	UniProtKB:P43488	Mouse	PMID:14635034
Biological Process	GO:0006954	inflammatory response	Tnfrsf4	IMP	MGI:MGI:1859871	Mouse	PMID:14730361
Biological Process	GO:0070236	negative regulation of activation-induced cell death of T cells	Tnfrsf4	IMP		Mouse	MGI:MGI:2150820|PMID:11567634
Biological Process	GO:0001818	negative regulation of cytokine production	Tnfrsf4	IPI	UniProtKB:P43488	Mouse	PMID:14635034
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Tnfrsf4	IDA		Mouse	MGI:MGI:74350|PMID:7749983
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Tnfrsf4	IDA		Mouse	MGI:MGI:74350|PMID:7749983
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Tnfrsf4	IMP		Mouse	MGI:MGI:2150820|PMID:11567634
Biological Process	GO:0030890	positive regulation of B cell proliferation	Tnfrsf4	IMP		Mouse	MGI:MGI:74350|PMID:7749983
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Tnfrsf4	IDA		Mouse	MGI:MGI:74350|PMID:7749983
Biological Process	GO:0042981	regulation of apoptotic process	Tnfrsf4	IMP	MGI:MGI:1859871	Mouse	PMID:14730361
Biological Process	GO:0045859	regulation of protein kinase activity	Tnfrsf4	IMP	MGI:MGI:1859871	Mouse	PMID:14730361
Biological Process	GO:0042098	T cell proliferation	Tnfrsf4	IMP		Rat	PMID:2828930|RGD:730097

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern