Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tnfsf11

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TNFSF11
- Mouse genes Tnfsf11
- Rat genes Tnfsf11
- Zfish genes tnfsf11
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnfsf11

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	TNFSF11	IDA		Human	PMID:15248232
Molecular Function	GO:0005125	cytokine activity	TNFSF11	IDA		Human	PMID:9367155
Molecular Function	GO:0042802	identical protein binding	Tnfsf11	IPI	PR:O35235	Mouse	PMID:11859102
Molecular Function	GO:0005515	protein binding	TNFSF11	IPI	UniProtKB:P98066	Human	PMID:18586671
Molecular Function	GO:0005515	protein binding	TNFSF11	IPI	UniProtKB:O00300	Human	PMID:22664871
Molecular Function	GO:0005515	protein binding	TNFSF11	IPI	UniProtKB:O00526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNFSF11	IPI	UniProtKB:Q6UX06	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Tnfsf11	IPI	UniProtKB:P35555	Mouse	MGI:MGI:5795811\|PMID:24039232
Molecular Function	GO:0005515	protein binding	Tnfsf11	IPI	UniProtKB:O08712\|UniProtKB:O35305	Mouse	MGI:MGI:5917007\|PMID:23039992
Molecular Function	GO:0005515	protein binding	Tnfsf11	IPI	UniProtKB:O35305	Mouse	MGI:MGI:5918211\|PMID:21059944
Molecular Function	GO:0005515	protein binding	Tnfsf11	IPI	PR:O35235	Mouse	PMID:11859102
Molecular Function	GO:0032813	tumor necrosis factor receptor superfamily binding	Tnfsf11	IPI	UniProtKB:Q9Y6Q6	Mouse	MGI:MGI:1099613\|PMID:9367155
Biological Process	GO:0009887	animal organ morphogenesis	Tnfsf11	IMP	MGI:MGI:1859962	Mouse	PMID:9950424
Biological Process	GO:0060348	bone development	Tnfsf11	IMP	MGI:MGI:5614816	Mouse	PMID:26234751
Biological Process	GO:0045453	bone resorption	Tnfsf11	IDA		Mouse	PMID:12490655
Biological Process	GO:0055074	calcium ion homeostasis	Tnfsf11	IGI	MGI:MGI:2158925	Mouse	PMID:21982707
Biological Process	GO:0019722	calcium-mediated signaling	Tnfsf11	IDA		Mouse	MGI:MGI:5795811\|PMID:24039232
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Tnfsf11	IEP		Mouse	PMID:20439489
Biological Process	GO:0019221	cytokine-mediated signaling pathway	TNFSF11	IDA		Human	PMID:15248232
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Tnfsf11	IDA		Mouse	MGI:MGI:3838421\|PMID:19252502
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Tnfsf11	IDA		Mouse	PMID:19298785
Biological Process	GO:0007254	JNK cascade	Tnfsf11	IGI	MGI:MGI:109520	Mouse	PMID:22073305
Biological Process	GO:0060749	mammary gland alveolus development	Tnfsf11	IMP	MGI:MGI:1859962	Mouse	PMID:11051546
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	Tnfsf11	IMP	MGI:MGI:1859962	Mouse	PMID:11051546
Biological Process	GO:0002548	monocyte chemotaxis	TNFSF11	IDA		Human	PMID:15248232
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tnfsf11	IMP		Mouse	MGI:MGI:6252929\|PMID:27336669
Biological Process	GO:0001503	ossification	Tnfsf11	IMP	MGI:MGI:1859962	Mouse	PMID:9950424
Biological Process	GO:0036035	osteoclast development	Tnfsf11	IDA		Mouse	PMID:21841309
Biological Process	GO:0030316	osteoclast differentiation	TNFSF11	IDA		Human	PMID:18606301
Biological Process	GO:0030316	osteoclast differentiation	Tnfsf11	IMP		Mouse	MGI:MGI:3575591\|PMID:15750601
Biological Process	GO:0030316	osteoclast differentiation	Tnfsf11	IGI	MGI:MGI:104798	Mouse	PMID:15485831
Biological Process	GO:0030316	osteoclast differentiation	Tnfsf11	IGI	MGI:MGI:99484	Mouse	PMID:15485831
Biological Process	GO:0030316	osteoclast differentiation	Tnfsf11	IDA		Mouse	PMID:14662855
Biological Process	GO:0030316	osteoclast differentiation	Tnfsf11	IGI	MGI:MGI:1339753	Mouse	PMID:17053831
Biological Process	GO:0030316	osteoclast differentiation	Tnfsf11	IDA		Mouse	PMID:15724149
Biological Process	GO:0030316	osteoclast differentiation	Tnfsf11	IDA		Mouse	PMID:17442941
Biological Process	GO:0002158	osteoclast proliferation	Tnfsf11	IDA		Mouse	PMID:22451653
Biological Process	GO:0038001	paracrine signaling	Tnfsf11	IDA		Mouse	PMID:24190884
Biological Process	GO:0045780	positive regulation of bone resorption	TNFSF11	IDA		Human	PMID:17241109
Biological Process	GO:0045780	positive regulation of bone resorption	Tnfsf11	IMP		Rat	PMID:11092398\|RGD:730134
Biological Process	GO:0051466	positive regulation of corticotropin-releasing hormone secretion	Tnfsf11	IDA		Mouse	MGI:MGI:4413614\|PMID:19940926
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Tnfsf11	IDA		Mouse	MGI:MGI:4413614\|PMID:19940926
Biological Process	GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	TNFSF11	IDA		Human	PMID:18606301
Biological Process	GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion	Tnfsf11	IDA		Mouse	MGI:MGI:4413614\|PMID:19940926
Biological Process	GO:0010628	positive regulation of gene expression	Tnfsf11	IDA		Mouse	PMID:17442941
Biological Process	GO:0010628	positive regulation of gene expression	Tnfsf11	IDA		Mouse	PMID:19715671
Biological Process	GO:0034112	positive regulation of homotypic cell-cell adhesion	TNFSF11	IDA		Human	PMID:9367155
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Tnfsf11	IDA		Mouse	PMID:19298785
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	TNFSF11	IDA		Human	PMID:15248232
Biological Process	GO:0046330	positive regulation of JNK cascade	Tnfsf11	IGI	MGI:MGI:109520	Mouse	PMID:22073305
Biological Process	GO:0043406	positive regulation of MAP kinase activity	TNFSF11	IDA		Human	PMID:15304486
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TNFSF11	IDA		Human	PMID:9367155
Biological Process	GO:2001206	positive regulation of osteoclast development	Tnfsf11	IDA		Mouse	PMID:23980096
Biological Process	GO:2001206	positive regulation of osteoclast development	Tnfsf11	IDA		Mouse	PMID:18269914
Biological Process	GO:2001206	positive regulation of osteoclast development	Tnfsf11	IDA		Mouse	PMID:22437732
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	TNFSF11	IDA		Human	PMID:15304486
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	TNFSF11	IDA		Human	PMID:17241109
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	TNFSF11	IDA		Human	PMID:19560569
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Tnfsf11	IGI	MGI:MGI:1339753	Mouse	PMID:21048959
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Tnfsf11	IDA		Mouse	PMID:15724149
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Tnfsf11	IDA		Mouse	PMID:15657444
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Tnfsf11	IGI	MGI:MGI:102469	Mouse	PMID:21982707
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Tnfsf11	IGI	MGI:MGI:1339753	Mouse	PMID:17053831
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Tnfsf11	IGI	MGI:MGI:2158925	Mouse	PMID:21982707
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Tnfsf11	IMP		Rat	PMID:11092398\|RGD:730134
Biological Process	GO:0042327	positive regulation of phosphorylation	Tnfsf11	IDA		Mouse	MGI:MGI:3838421\|PMID:19252502
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Tnfsf11	IMP	MGI:MGI:1859962	Mouse	PMID:11051546
Biological Process	GO:0050870	positive regulation of T cell activation	TNFSF11	IDA		Human	PMID:9367155
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TNFSF11	IDA		Human	PMID:15304486
Biological Process	GO:0043491	protein kinase B signaling	Tnfsf11	IMP	MGI:MGI:1859962	Mouse	PMID:11051546
Biological Process	GO:1904616	regulation of actin binding	Tnfsf11	IDA		Mouse	PMID:19715671
Biological Process	GO:0045670	regulation of osteoclast differentiation	Tnfsf11	IDA		Mouse	PMID:12490655
Biological Process	GO:0045670	regulation of osteoclast differentiation	Tnfsf11	IDA		Mouse	PMID:23395171
Biological Process	GO:0045471	response to ethanol	Tnfsf11	IEP		Rat	PMID:22576626\|RGD:151667429
Biological Process	GO:0035902	response to immobilization stress	Tnfsf11	IEP		Rat	PMID:18380564\|RGD:2302362
Biological Process	GO:0009612	response to mechanical stimulus	tnfsf11	IDA		Zfish	PMID:23632157
Biological Process	GO:0009314	response to radiation	Tnfsf11	IEP		Rat	PMID:16752412\|RGD:2302322
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	TNFSF11	IDA		Human	PMID:18606301
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	Tnfsf11	IDA		Mouse	PMID:18269914
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	Tnfsf11	IDA		Mouse	PMID:22437732
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	Tnfsf11	IDA		Mouse	PMID:17442941
Biological Process	GO:0044691	tooth eruption	Tnfsf11	IMP	MGI:MGI:5614816	Mouse	PMID:26234751
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	Tnfsf11	IGI	UniProtKB:O35305	Mouse	MGI:MGI:4413614\|PMID:19940926

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.