Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TNFSF4
  • Mouse genes Tnfsf4
  • Rat genes Tnfsf4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnfsf4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TNFSF4	IPI	UniProtKB:P43488	Human	PMID:16905106
Molecular Function	GO:0005515	protein binding	TNFSF4	IPI	UniProtKB:P43489	Human	PMID:16905106
Molecular Function	GO:0005515	protein binding	Tnfsf4	IPI	UniProtKB:P23510	Mouse	MGI:MGI:5926345|PMID:16905106
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	Tnfsf4	IPI	PR:P47741	Mouse	PMID:14635034
Molecular Function	GO:0032813	tumor necrosis factor receptor superfamily binding	Tnfsf4	IPI	UniProtKB:P47741	Mouse	MGI:MGI:74350|PMID:7749983
Molecular Function	GO:0032813	tumor necrosis factor receptor superfamily binding	Tnfsf4	IMP		Rat	PMID:10772947|RGD:2289071
Molecular Function	GO:0032813	tumor necrosis factor receptor superfamily binding	Tnfsf4	IPI	RGD:737375	Rat	PMID:9790919|RGD:634509
Cellular Component	GO:0009986	cell surface	TNFSF4	IDA		Human	PMID:18397322
Cellular Component	GO:0009986	cell surface	Tnfsf4	IDA		Rat	PMID:9790919|RGD:634509
Cellular Component	GO:0005615	extracellular space	TNFSF4	IDA		Human	PMID:17166734
Biological Process	GO:0002526	acute inflammatory response	Tnfsf4	IMP		Mouse	MGI:MGI:4835591|PMID:20844189
Biological Process	GO:0035783	CD4-positive, alpha-beta T cell costimulation	Tnfsf4	IDA		Mouse	MGI:MGI:4819294|PMID:20639485
Biological Process	GO:0071222	cellular response to lipopolysaccharide	TNFSF4	IDA		Human	PMID:20844189
Biological Process	GO:0035714	cellular response to nitrogen dioxide	Tnfsf4	IMP		Mouse	MGI:MGI:4943801|PMID:20659336
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	TNFSF4	IDA		Human	PMID:19029446
Biological Process	GO:0008203	cholesterol metabolic process	Tnfsf4	IMP		Mouse	PMID:3473481
Biological Process	GO:0002215	defense response to nematode	Tnfsf4	IMP		Mouse	MGI:MGI:3763508|PMID:12496423
Biological Process	GO:0006954	inflammatory response	Tnfsf4	IPI	PR:P47741	Mouse	PMID:14635034
Biological Process	GO:0035709	memory T cell activation	Tnfsf4	IMP		Mouse	MGI:MGI:3763508|PMID:12496423
Biological Process	GO:0001818	negative regulation of cytokine production	Tnfsf4	IPI	PR:P47741	Mouse	PMID:14635034
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Tnfsf4	IDA		Mouse	MGI:MGI:74350|PMID:7749983
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Tnfsf4	IDA		Mouse	MGI:MGI:74350|PMID:7749983
Biological Process	GO:0032700	negative regulation of interleukin-17 production	TNFSF4	IDA		Human	PMID:18501882
Biological Process	GO:0045590	negative regulation of regulatory T cell differentiation	Tnfsf4	IMP		Mouse	MGI:MGI:3806904|PMID:18713990
Biological Process	GO:0045626	negative regulation of T-helper 1 cell differentiation	Tnfsf4	IDA		Mouse	MGI:MGI:4942267|PMID:9670042
Biological Process	GO:0032689	negative regulation of type II interferon production	Tnfsf4	IDA		Mouse	MGI:MGI:4942267|PMID:9670042
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Tnfsf4	IDA		Rat	PMID:9790919|RGD:634509
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation	Tnfsf4	IMP		Mouse	MGI:MGI:3772919|PMID:16670306
Biological Process	GO:0050871	positive regulation of B cell activation	Tnfsf4	IDA		Mouse	MGI:MGI:4942267|PMID:9670042
Biological Process	GO:1900281	positive regulation of CD4-positive, alpha-beta T cell costimulation	Tnfsf4	IDA		Mouse	MGI:MGI:4819294|PMID:20639485
Biological Process	GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation	Tnfsf4	IDA		Mouse	MGI:MGI:4819294|PMID:20639485
Biological Process	GO:0032722	positive regulation of chemokine production	Tnfsf4	IMP		Mouse	MGI:MGI:4942253|PMID:12355440
Biological Process	GO:0002891	positive regulation of immunoglobulin mediated immune response	Tnfsf4	IMP		Mouse	MGI:MGI:3763508|PMID:12496423
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Tnfsf4	IDA		Mouse	MGI:MGI:74350|PMID:7749983
Biological Process	GO:0050729	positive regulation of inflammatory response	TNFSF4	IDA		Human	PMID:20844189
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Tnfsf4	IMP		Mouse	MGI:MGI:4835591|PMID:20844189
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Tnfsf4	IMP		Mouse	MGI:MGI:4835591|PMID:20844189
Biological Process	GO:0032736	positive regulation of interleukin-13 production	Tnfsf4	IDA		Mouse	MGI:MGI:4943387|PMID:18354165
Biological Process	GO:0032743	positive regulation of interleukin-2 production	Tnfsf4	IDA		Rat	PMID:9790919|RGD:634509
Biological Process	GO:0032753	positive regulation of interleukin-4 production	TNFSF4	IDA		Human	PMID:18501882
Biological Process	GO:0032753	positive regulation of interleukin-4 production	Tnfsf4	IDA		Mouse	MGI:MGI:4942267|PMID:9670042
Biological Process	GO:0032753	positive regulation of interleukin-4 production	Tnfsf4	IDA		Mouse	MGI:MGI:4943387|PMID:18354165
Biological Process	GO:0032753	positive regulation of interleukin-4 production	Tnfsf4	IMP		Mouse	MGI:MGI:3763508|PMID:12496423
Biological Process	GO:2000572	positive regulation of interleukin-4-dependent isotype switching to IgE isotypes	Tnfsf4	IMP		Mouse	MGI:MGI:3763508|PMID:12496423
Biological Process	GO:0032755	positive regulation of interleukin-6 production	TNFSF4	IDA		Human	PMID:20844189
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tnfsf4	IMP		Mouse	MGI:MGI:4835591|PMID:20844189
Biological Process	GO:2000568	positive regulation of memory T cell activation	Tnfsf4	IMP		Mouse	MGI:MGI:3763508|PMID:12496423
Biological Process	GO:0043382	positive regulation of memory T cell differentiation	Tnfsf4	IDA		Mouse	MGI:MGI:3806904|PMID:18713990
Biological Process	GO:2000525	positive regulation of T cell costimulation	Tnfsf4	IDA		Mouse	MGI:MGI:4819294|PMID:20639485
Biological Process	GO:0002726	positive regulation of T cell cytokine production	Tnfsf4	IDA		Mouse	MGI:MGI:4942267|PMID:9670042
Biological Process	GO:0002726	positive regulation of T cell cytokine production	Tnfsf4	IDA		Mouse	MGI:MGI:4943387|PMID:18354165
Biological Process	GO:2000570	positive regulation of T-helper 2 cell activation	Tnfsf4	IMP		Mouse	MGI:MGI:3763508|PMID:12496423
Biological Process	GO:0045630	positive regulation of T-helper 2 cell differentiation	Tnfsf4	IDA		Mouse	MGI:MGI:4943387|PMID:18354165
Biological Process	GO:0002830	positive regulation of type 2 immune response	Tnfsf4	IMP		Mouse	MGI:MGI:3763508|PMID:12496423
Biological Process	GO:0002830	positive regulation of type 2 immune response	Tnfsf4	IDA		Mouse	MGI:MGI:4943387|PMID:18354165
Biological Process	GO:0002830	positive regulation of type 2 immune response	Tnfsf4	IMP		Mouse	MGI:MGI:4355816|PMID:17785785
Biological Process	GO:0032729	positive regulation of type II interferon production	TNFSF4	IDA		Human	PMID:18501882
Biological Process	GO:0032729	positive regulation of type II interferon production	Tnfsf4	IMP		Mouse	MGI:MGI:3806904|PMID:18713990
Biological Process	GO:0002819	regulation of adaptive immune response	Tnfsf4	IDA		Mouse	MGI:MGI:4835591|PMID:20844189
Biological Process	GO:0050727	regulation of inflammatory response	Tnfsf4	IDA		Mouse	MGI:MGI:4942253|PMID:12355440
Biological Process	GO:0035713	response to nitrogen dioxide	Tnfsf4	IDA		Mouse	MGI:MGI:4943801|PMID:20659336
Biological Process	GO:0009615	response to virus	Tnfsf4	IDA		Mouse	MGI:MGI:4819294|PMID:20639485
Biological Process	GO:0042098	T cell proliferation	Tnfsf4	IMP		Rat	PMID:10772947|RGD:2289071
Biological Process	GO:0035712	T-helper 2 cell activation	Tnfsf4	IMP		Mouse	MGI:MGI:3763508|PMID:12496423

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern