Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TNIK
  • Mouse genes Tnik
  • Rat genes Tnik
  • Zfish genes tnika,tnikb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnik

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:P16333	Human	PMID:10521462
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:Q12933	Human	PMID:10521462
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:P10114	Human	PMID:15342639
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:Q6F6B3	Human	PMID:18930710
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:P35222	Human	PMID:19816403
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:Q9NQB0	Human	PMID:19816403
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:P10114	Human	PMID:20159449
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:P46934	Human	PMID:20159449
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:O14920	Human	PMID:22904686
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:O43318	Human	PMID:22904686
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:P03230	Human	PMID:22904686
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:Q12933	Human	PMID:22904686
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:Q9NYJ8	Human	PMID:22904686
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:Q9Y4K3	Human	PMID:22904686
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:Q9NRI5	Human	PMID:29961565
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:Q9NRI5	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	TNIK	IPI	UniProtKB:Q9NRI5	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Tnik	IPI	UniProtKB:P46935|UniProtKB:Q80ZJ1	Mouse	MGI:MGI:4835109|PMID:20159449
Molecular Function	GO:0004672	protein kinase activity	TNIK	IDA		Human	PMID:22797597
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TNIK	IDA		Human	PMID:10521462
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TNIK	IDA		Human	PMID:15342639
Cellular Component	GO:0016324	apical plasma membrane	TNIK	IDA		Human	PMID:22797597
Cellular Component	GO:0005737	cytoplasm	TNIK	IDA		Human	PMID:15342639
Cellular Component	GO:0005737	cytoplasm	TNIK	IDA		Human	PMID:19061864
Cellular Component	GO:0005856	cytoskeleton	TNIK	IDA		Human	PMID:15342639
Cellular Component	GO:0005829	cytosol	TNIK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	TNIK	HDA		Human	PMID:20458337
Cellular Component	GO:0098978	glutamatergic synapse	Tnik	IMP		Mouse	PMID:23035106
Cellular Component	GO:0098978	glutamatergic synapse	Tnik	IDA		Mouse	PMID:23035106
Cellular Component	GO:0098978	glutamatergic synapse	Tnik	IPI		Mouse	PMID:23035106
Cellular Component	GO:0098978	glutamatergic synapse	Tnik	IDA		Rat	PMID:20838393|RGD:13702418
Cellular Component	GO:0005654	nucleoplasm	TNIK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TNIK	IDA		Human	PMID:19816403
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Tnik	IDA		Rat	PMID:20838393|RGD:13702418
Cellular Component	GO:0098793	presynapse	Tnik	IDA		Rat	PMID:20838393|RGD:13702418
Biological Process	GO:0031532	actin cytoskeleton reorganization	TNIK	IDA		Human	PMID:15342639
Biological Process	GO:0060027	convergent extension involved in gastrulation	tnika	IMP	ZFIN:ZDB-MRPHLNO-070124-1	Zfish	PMID:16794032
Biological Process	GO:0007010	cytoskeleton organization	TNIK	IMP		Human	PMID:10521462
Biological Process	GO:0007369	gastrulation	tnika	IMP	ZFIN:ZDB-MRPHLNO-070124-1	Zfish	PMID:16794032
Biological Process	GO:0007369	gastrulation	tnika	IMP	ZFIN:ZDB-MRPHLNO-070124-2	Zfish	PMID:16794032
Biological Process	GO:0007369	gastrulation	tnika	IMP	ZFIN:ZDB-MRPHLNO-070124-3	Zfish	PMID:16794032
Biological Process	GO:0035556	intracellular signal transduction	TNIK	IDA		Human	PMID:10521462
Biological Process	GO:0030033	microvillus assembly	TNIK	IMP		Human	PMID:22797597
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Tnik	IMP		Rat	PMID:21048137|RGD:8553980
Biological Process	GO:0046330	positive regulation of JNK cascade	TNIK	IMP		Human	PMID:10521462
Biological Process	GO:0046330	positive regulation of JNK cascade	TNIK	IDA		Human	PMID:15342639
Biological Process	GO:0001934	positive regulation of protein phosphorylation	TNIK	IMP		Human	PMID:22797597
Biological Process	GO:0046777	protein autophosphorylation	TNIK	IDA		Human	PMID:10521462
Biological Process	GO:0046777	protein autophosphorylation	TNIK	IDA		Human	PMID:15342639
Biological Process	GO:0072659	protein localization to plasma membrane	TNIK	IMP		Human	PMID:22797597
Biological Process	GO:0006468	protein phosphorylation	TNIK	IDA		Human	PMID:10521462
Biological Process	GO:0006468	protein phosphorylation	TNIK	IDA		Human	PMID:15342639
Biological Process	GO:0006468	protein phosphorylation	TNIK	IDA		Human	PMID:22797597
Biological Process	GO:0008360	regulation of cell shape	tnika	IMP	ZFIN:ZDB-MRPHLNO-070124-1	Zfish	PMID:16794032
Biological Process	GO:0048814	regulation of dendrite morphogenesis	TNIK	IDA		Human	PMID:20159449
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Tnik	IDA		Mouse	PMID:23035106
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Tnik	IMP		Mouse	PMID:23035106
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Tnik	IPI		Mouse	PMID:23035106
Biological Process	GO:0010243	response to organonitrogen compound	Tnik	IEP		Rat	PMID:22242189|RGD:151347836

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern