Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TNKS
  • Mouse genes Tnks
  • Rat genes Tnks
  • Zfish genes tnksa,tnksb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnks

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042393	histone binding	TNKS	IPI	UniProtKB:O75367	Human	PMID:26373281
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	TNKS	IDA		Human	PMID:11854288
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	TNKS	IDA		Human	PMID:16076287
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	TNKS	IDA		Human	PMID:19759537
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	TNKS	IDA		Human	PMID:21270334
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	TNKS	IDA		Human	PMID:21478859
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	TNKS	IDA		Human	PMID:22864114
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	TNKS	IDA		Human	PMID:9822378
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	TNKS	IDA		Human	PMID:15133513
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	TNKS	IDA		Human	PMID:25043379
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	TNKS	IDA		Human	PMID:9822378
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:P54274	Human	PMID:11854288
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9C0C2	Human	PMID:11854288
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:P54274	Human	PMID:12080061
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q14980	Human	PMID:12080061
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9C0C2	Human	PMID:12080061
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9NUX5	Human	PMID:12768206
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q96RU3	Human	PMID:14596906
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:P54274	Human	PMID:15133513
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q14980	Human	PMID:16076287
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9NWT6	Human	PMID:17003112
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:O15169	Human	PMID:19759537
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:O35625	Human	PMID:19759537
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9Y2T1	Human	PMID:19759537
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:P54274	Human	PMID:20696165
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9NWT6	Human	PMID:21251231
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:O15169	Human	PMID:21478859
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:O15234	Human	PMID:21478859
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9H2G9	Human	PMID:21478859
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9Y2T1	Human	PMID:21478859
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9NTX7	Human	PMID:21799911
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9HC77	Human	PMID:22699936
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:A8MVW5	Human	PMID:22864114
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9NTX7	Human	PMID:25327252
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:O75367-2	Human	PMID:26373281
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:P54274	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9NWT6	Human	PMID:26972000
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9BS91	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9H2G9	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9NWT6	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q3KP66	Human	PMID:29420262
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:O00560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:P56279	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q7L775	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q8TF42	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9NX46	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9Y530	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:P52272	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q14980	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q3KP66	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9BS91	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:Q9H2G9	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	TNKS	IPI	UniProtKB:P54274	Human	PMID:9822378
Molecular Function	GO:0008270	zinc ion binding	TNKS	IDA		Human	PMID:18436240
Cellular Component	GO:0000781	chromosome, telomeric region	TNKS	IDA		Human	PMID:11739745
Cellular Component	GO:0000781	chromosome, telomeric region	TNKS	IDA		Human	PMID:9822378
Cellular Component	GO:0005829	cytosol	Tnks	IDA		Mouse	PMID:23791195
Cellular Component	GO:0005794	Golgi apparatus	TNKS	IDA		Human	PMID:22864114
Cellular Component	GO:0097431	mitotic spindle pole	TNKS	IDA		Human	PMID:16076287
Cellular Component	GO:0016604	nuclear body	TNKS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031965	nuclear membrane	TNKS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TNKS	IDA		Human	GO_REF:0000052
Biological Process	GO:0031670	cellular response to nutrient	Tnks	IEP		Rat	PMID:25876076|RGD:13628743
Biological Process	GO:0042593	glucose homeostasis	tnksb	IMP	ZFIN:ZDB-MRPHLNO-160216-2	Zfish	PMID:26169937
Biological Process	GO:1904908	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	TNKS	IMP		Human	PMID:26373281
Biological Process	GO:1904357	negative regulation of telomere maintenance via telomere lengthening	TNKS	IMP		Human	PMID:25939383
Biological Process	GO:1904743	negative regulation of telomeric DNA binding	TNKS	IMP		Human	PMID:25939383
Biological Process	GO:1904743	negative regulation of telomeric DNA binding	TNKS	IDA		Human	PMID:9822378
Biological Process	GO:0018105	peptidyl-serine phosphorylation	TNKS	IDA		Human	PMID:17026964
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	TNKS	IDA		Human	PMID:17026964
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	TNKS	IMP		Human	PMID:19759537
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	TNKS	IMP		Human	PMID:25939383
Biological Process	GO:0051973	positive regulation of telomerase activity	TNKS	IDA		Human	PMID:12782650
Biological Process	GO:1904355	positive regulation of telomere capping	TNKS	IDA		Human	PMID:21531765
Biological Process	GO:1904355	positive regulation of telomere capping	TNKS	IMP		Human	PMID:25939383
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	TNKS	IMP		Human	PMID:11739745
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	TNKS	IDA		Human	PMID:12782650
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	TNKS	IDA		Human	PMID:18221737
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TNKS	IDA		Human	PMID:19245366
Biological Process	GO:0070213	protein auto-ADP-ribosylation	TNKS	IDA		Human	PMID:21478859
Biological Process	GO:0070198	protein localization to chromosome, telomeric region	TNKS	IMP		Human	PMID:15133513
Biological Process	GO:0070198	protein localization to chromosome, telomeric region	TNKS	IMP		Human	PMID:18221737
Biological Process	GO:0070212	protein poly-ADP-ribosylation	TNKS	IDA		Human	PMID:16076287
Biological Process	GO:0070212	protein poly-ADP-ribosylation	TNKS	IDA		Human	PMID:25043379
Biological Process	GO:0070212	protein poly-ADP-ribosylation	TNKS	IMP		Human	PMID:25939383
Biological Process	GO:0070212	protein poly-ADP-ribosylation	TNKS	IDA		Human	PMID:9822378
Biological Process	GO:0000209	protein polyubiquitination	TNKS	IDA		Human	PMID:19759537
Biological Process	GO:0000209	protein polyubiquitination	TNKS	IDA		Human	PMID:21478859

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern