Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TNNC1
  • Mouse genes Tnnc1
  • Rat genes Tnnc1
  • Zfish genes tnnc1a,tnnc1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnnc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	Tnnc1	IDA		Mouse	MGI:MGI:3793921|PMID:8785301
Molecular Function	GO:0005509	calcium ion binding	TNNC1	IDA		Human	PMID:12840750
Molecular Function	GO:0005509	calcium ion binding	TNNC1	IDA		Human	PMID:18092822
Molecular Function	GO:0005509	calcium ion binding	Tnnc1	IDA		Rat	PMID:8557674|RGD:1598618
Molecular Function	GO:0048306	calcium-dependent protein binding	TNNC1	IPI	UniProtKB:P19429	Human	PMID:7957210
Molecular Function	GO:0005515	protein binding	TNNC1	IPI	UniProtKB:P19429	Human	PMID:10806205
Molecular Function	GO:0005515	protein binding	TNNC1	IPI	UniProtKB:P19237	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	TNNC1	IPI	UniProtKB:P19237	Human	PMID:32296183
Molecular Function	GO:0042803	protein homodimerization activity	TNNC1	IDA		Human	PMID:18092822
Molecular Function	GO:0031013	troponin I binding	TNNC1	IPI	UniProtKB:P19429	Human	PMID:11735257
Molecular Function	GO:0031013	troponin I binding	TNNC1	IPI	UniProtKB:P19429	Human	PMID:15542288
Molecular Function	GO:0031013	troponin I binding	TNNC1	IDA		Human	PMID:18092822
Molecular Function	GO:0031013	troponin I binding	TNNC1	IPI	UniProtKB:P19429	Human	PMID:7957210
Molecular Function	GO:0031014	troponin T binding	TNNC1	IPI	UniProtKB:P45379	Human	PMID:15542288
Molecular Function	GO:0031014	troponin T binding	TNNC1	IPI	UniProtKB:P45379	Human	PMID:8205619
Cellular Component	GO:1990584	cardiac Troponin complex	TNNC1	IDA		Human	PMID:25771144
Cellular Component	GO:0043292	contractile fiber	Tnnc1	IDA		Rat	PMID:14985239|RGD:1598612
Cellular Component	GO:0043292	contractile fiber	Tnnc1	IDA		Rat	PMID:9409484|RGD:1600167
Cellular Component	GO:0005861	troponin complex	TNNC1	IDA		Human	PMID:10850966
Cellular Component	GO:0005861	troponin complex	TNNC1	IDA		Human	PMID:12093807
Biological Process	GO:0060048	cardiac muscle contraction	TNNC1	IMP		Human	PMID:15542288
Biological Process	GO:0060048	cardiac muscle contraction	TNNC1	IDA		Human	PMID:25771144
Biological Process	GO:0060048	cardiac muscle contraction	Tnnc1	IMP		Rat	PMID:9409484|RGD:1600167
Biological Process	GO:0060048	cardiac muscle contraction	tnnc1a	IMP	ZFIN:ZDB-GENO-101130-4	Zfish	PMID:20925115
Biological Process	GO:0060048	cardiac muscle contraction	tnnc1a	IMP	ZFIN:ZDB-MRPHLNO-101108-9	Zfish	PMID:20925115
Biological Process	GO:0060048	cardiac muscle contraction	tnnc1a	IMP	ZFIN:ZDB-GENO-101108-2	Zfish	PMID:20925115
Biological Process	GO:0060048	cardiac muscle contraction	tnnc1b	IMP	ZFIN:ZDB-MRPHLNO-101108-10	Zfish	PMID:20925115
Biological Process	GO:0003231	cardiac ventricle development	tnnc1a	IMP	ZFIN:ZDB-GENO-101108-2	Zfish	PMID:20925115
Biological Process	GO:0003231	cardiac ventricle development	tnnc1a	IMP	ZFIN:ZDB-GENO-101130-4	Zfish	PMID:20925115
Biological Process	GO:0003231	cardiac ventricle development	tnnc1a	IMP	ZFIN:ZDB-MRPHLNO-101108-9	Zfish	PMID:20925115
Biological Process	GO:0002086	diaphragm contraction	Tnnc1	IDA		Rat	PMID:14985239|RGD:1598612
Biological Process	GO:0043462	regulation of ATP-dependent activity	Tnnc1	IDA		Mouse	MGI:MGI:3793921|PMID:8785301
Biological Process	GO:0006937	regulation of muscle contraction	TNNC1	IDA		Human	PMID:18092822
Biological Process	GO:0032972	regulation of muscle filament sliding speed	Tnnc1	IMP		Mouse	MGI:MGI:3793933|PMID:10747195
Biological Process	GO:0014823	response to activity	tnnc1a	IDA		Zfish	PMID:16966387
Biological Process	GO:0010038	response to metal ion	Tnnc1	IDA		Rat	PMID:14985239|RGD:1598612
Biological Process	GO:0014883	transition between fast and slow fiber	Tnnc1	IDA		Mouse	PMID:18978355
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	TNNC1	IMP		Human	PMID:15542288

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern