Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TNNI3
  • Mouse genes Tnni3
  • Rat genes Tnni3
  • Zfish genes tnni2a.1,tnni2a.2,tnni2a.3,tnni2a.4,tnni2b.1,tnni2b.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnni3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	TNNI3	IDA		Human	PMID:10806205
Molecular Function	GO:0051015	actin filament binding	TNNI3	IPI	UniProtKB:P58772,UniProtKB:P68135	Human	PMID:25771144
Molecular Function	GO:0051015	actin filament binding	TNNI3	IPI	UniProtKB:P68135	Human	PMID:25771144
Molecular Function	GO:0019855	calcium channel inhibitor activity	TNNI3	IPI	UniProtKB:Q13563	Human	PMID:12809519
Molecular Function	GO:0048306	calcium-dependent protein binding	TNNI3	IPI	UniProtKB:P63316	Human	PMID:7957210
Molecular Function	GO:0140678	molecular function inhibitor activity	TNNI3	EXP		Human	PMID:12840750
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:P63316	Human	PMID:10806205
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:Q13563	Human	PMID:12525172
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:Q9P0L9	Human	PMID:12525172
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:Q59H18	Human	PMID:12721663
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:Q13563	Human	PMID:12809519
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:Q9P0L9	Human	PMID:12809519
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:Q9UKA8	Human	PMID:16516408
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:Q9UKA8-1	Human	PMID:16516408
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:Q9UKA8-4	Human	PMID:16516408
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:Q13043	Human	PMID:18986304
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:Q5VU43-11	Human	PMID:21569246
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:Q59H18-2	Human	PMID:23369981
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:P02585	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:A6NK89	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:O43933	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TNNI3	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Tnni3	IPI	UniProtKB:Q5VU43-11	Rat	PMID:21569246|RGD:10047194
Molecular Function	GO:0019904	protein domain specific binding	TNNI3	IPI	UniProtKB:Q99698	Human	PMID:11984006
Molecular Function	GO:0019901	protein kinase binding	TNNI3	IPI	UniProtKB:Q59H18	Human	PMID:12721663
Molecular Function	GO:0030172	troponin C binding	TNNI3	IPI	UniProtKB:P63316	Human	PMID:11735257
Molecular Function	GO:0030172	troponin C binding	TNNI3	IPI	UniProtKB:P63316	Human	PMID:15542288
Molecular Function	GO:0030172	troponin C binding	TNNI3	IPI	UniProtKB:P63316	Human	PMID:7957210
Molecular Function	GO:0031014	troponin T binding	TNNI3	IPI	UniProtKB:P45379	Human	PMID:15542288
Cellular Component	GO:0097512	cardiac myofibril	TNNI3	IMP		Human	PMID:25771144
Cellular Component	GO:1990584	cardiac Troponin complex	TNNI3	IMP		Human	PMID:25771144
Cellular Component	GO:0043292	contractile fiber	Tnni3	IDA		Rat	PMID:9409484|RGD:1600167
Cellular Component	GO:0005737	cytoplasm	Tnni3	IDA		Rat	PMID:15601779|RGD:8553397
Cellular Component	GO:0030016	myofibril	Tnni3	IDA		Rat	PMID:11448842|RGD:1600178
Cellular Component	GO:0030017	sarcomere	Tnni3	IDA		Mouse	PMID:16481394
Cellular Component	GO:0030017	sarcomere	Tnni3	IDA		Rat	PMID:15601779|RGD:8553397
Cellular Component	GO:0005861	troponin complex	TNNI3	IDA		Human	PMID:10806205
Cellular Component	GO:0005861	troponin complex	TNNI3	IDA		Human	PMID:10850966
Cellular Component	GO:0005861	troponin complex	TNNI3	IDA		Human	PMID:12093807
Cellular Component	GO:0005861	troponin complex	TNNI3	IDA		Human	PMID:7957210
Biological Process	GO:0060048	cardiac muscle contraction	TNNI3	IMP		Human	PMID:11735257
Biological Process	GO:0060048	cardiac muscle contraction	Tnni3	IDA		Rat	PMID:11448842|RGD:1600178
Biological Process	GO:0060048	cardiac muscle contraction	Tnni3	IDA		Rat	PMID:14551059|RGD:1600569
Biological Process	GO:0060048	cardiac muscle contraction	Tnni3	IMP		Rat	PMID:9409484|RGD:1600167
Biological Process	GO:0060047	heart contraction	TNNI3	IMP		Human	PMID:12531876
Biological Process	GO:0007507	heart development	Tnni3	IDA		Mouse	PMID:15611140
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Tnni3	IMP		Mouse	PMID:11158984
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Tnni3	IDA		Mouse	PMID:11356618
Biological Process	GO:0030239	myofibril assembly	tnni2a.4	IMP	ZFIN:ZDB-GENO-100507-15	Zfish	PMID:21245197
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	TNNI3	IMP		Human	PMID:10806205
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	TNNI3	IDA		Human	PMID:11735257
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	TNNI3	IDA		Human	PMID:7957210
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	TNNI3	IMP		Human	PMID:25771144
Biological Process	GO:0006937	regulation of muscle contraction	Tnni3	IDA		Mouse	PMID:12551921
Biological Process	GO:0006940	regulation of smooth muscle contraction	Tnni3	IMP		Rat	PMID:16236710|RGD:1580418
Biological Process	GO:0001980	regulation of systemic arterial blood pressure by ischemic conditions	Tnni3	IMP		Mouse	PMID:11158984
Biological Process	GO:0006941	striated muscle contraction	Tnni3	IDA		Mouse	PMID:11356618
Biological Process	GO:0006941	striated muscle contraction	Tnni3	IDA		Mouse	PMID:10642551
Biological Process	GO:0001570	vasculogenesis	Tnni3	IDA		Mouse	PMID:15611140
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	TNNI3	IMP		Human	PMID:11815426
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	TNNI3	IMP		Human	PMID:16754800

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern