Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TNNT2
  • Mouse genes Tnnt2
  • Rat genes Tnnt2
  • Zfish genes tnnt2a,tnnt2b,tnnt2c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnnt2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	TNNT2	IDA		Human	PMID:8205619
Molecular Function	GO:0005515	protein binding	TNNT2	IPI	UniProtKB:Q15014	Human	PMID:25416956
Molecular Function	GO:0044877	protein-containing complex binding	Tnnt2	IPI	RGD:1309921|RGD:11434	Rat	PMID:12501194|RGD:1580426
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Tnnt2	IDA		Rat	PMID:16443664|RGD:1580456
Molecular Function	GO:0005200	structural constituent of cytoskeleton	Tnnt2	IDA		Mouse	PMID:12832403
Molecular Function	GO:0005523	tropomyosin binding	TNNT2	IDA		Human	PMID:10850966
Molecular Function	GO:0030172	troponin C binding	TNNT2	IPI	UniProtKB:P63316	Human	PMID:15542288
Molecular Function	GO:0030172	troponin C binding	TNNT2	IPI	UniProtKB:P63316	Human	PMID:8205619
Molecular Function	GO:0031013	troponin I binding	TNNT2	IPI	UniProtKB:P19429	Human	PMID:15542288
Molecular Function	GO:0031013	troponin I binding	Tnnt2	IPI	RGD:11434	Rat	PMID:12501194|RGD:1580426
Cellular Component	GO:0097512	cardiac myofibril	TNNT2	IDA		Human	PMID:25771144
Cellular Component	GO:1990584	cardiac Troponin complex	TNNT2	IDA		Human	PMID:25771144
Cellular Component	GO:0030016	myofibril	Tnnt2	IDA		Mouse	PMID:18781631
Cellular Component	GO:0030016	myofibril	Tnnt2	IDA		Mouse	PMID:10449439
Cellular Component	GO:0030016	myofibril	Tnnt2	IDA		Rat	PMID:11448842|RGD:1600178
Cellular Component	GO:0030017	sarcomere	Tnnt2	IDA		Mouse	PMID:24364879
Cellular Component	GO:0030017	sarcomere	Tnnt2	IDA		Mouse	PMID:12738802
Cellular Component	GO:0030017	sarcomere	Tnnt2	IDA		Mouse	PMID:16326803
Cellular Component	GO:0016528	sarcoplasm	Tnnt2	IDA		Mouse	PMID:15830381
Cellular Component	GO:0005865	striated muscle thin filament	TNNT2	IDA		Human	PMID:12186860
Cellular Component	GO:0005861	troponin complex	TNNT2	IDA		Human	PMID:12186860
Cellular Component	GO:0005861	troponin complex	Tnnt2	IDA		Mouse	PMID:12832403
Cellular Component	GO:0005861	troponin complex	Tnnt2	IDA		Rat	PMID:12501194|RGD:1580426
Cellular Component	GO:0005861	troponin complex	tnnt2a	IMP	ZFIN:ZDB-GENO-980202-320	Zfish	PMID:11967535
Biological Process	GO:0051764	actin crosslink formation	Tnnt2	IDA		Rat	PMID:16443664|RGD:1580456
Biological Process	GO:0060840	artery development	tnnt2a	IMP	ZFIN:ZDB-GENO-120201-6	Zfish	PMID:19450519
Biological Process	GO:0055009	atrial cardiac muscle tissue morphogenesis	Tnnt2	IMP	MGI:MGI:3692450	Mouse	PMID:10449439
Biological Process	GO:0055009	atrial cardiac muscle tissue morphogenesis	Tnnt2	IMP	MGI:MGI:3692448	Mouse	PMID:10449439
Biological Process	GO:0055009	atrial cardiac muscle tissue morphogenesis	Tnnt2	IMP	MGI:MGI:3692451	Mouse	PMID:10449439
Biological Process	GO:0008015	blood circulation	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:18417622
Biological Process	GO:0008015	blood circulation	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:16753140
Biological Process	GO:0008015	blood circulation	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:18469344
Biological Process	GO:0008015	blood circulation	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:23863480
Biological Process	GO:0001568	blood vessel development	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:20549735
Biological Process	GO:0001568	blood vessel development	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:24990152
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:22937010
Biological Process	GO:0060048	cardiac muscle contraction	TNNT2	IDA		Human	PMID:25771144
Biological Process	GO:0060048	cardiac muscle contraction	Tnnt2	IDA		Rat	PMID:11448842|RGD:1600178
Biological Process	GO:0060047	heart contraction	tnnt2a	IMP	ZFIN:ZDB-GENO-220915-4	Zfish	PMID:33924051
Biological Process	GO:0060047	heart contraction	tnnt2a	IMP	ZFIN:ZDB-GENO-220915-1	Zfish	PMID:33924051
Biological Process	GO:0060047	heart contraction	tnnt2a	IMP	ZFIN:ZDB-GENO-220915-3	Zfish	PMID:33924051
Biological Process	GO:0060047	heart contraction	tnnt2a	IMP	ZFIN:ZDB-GENO-980202-1038	Zfish	PMID:9007249
Biological Process	GO:0060047	heart contraction	tnnt2a	IMP	ZFIN:ZDB-GENO-070808-2	Zfish	PMID:9007249
Biological Process	GO:0060047	heart contraction	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:19800866
Biological Process	GO:0060047	heart contraction	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:17592134
Biological Process	GO:0060047	heart contraction	tnnt2a	IMP	ZFIN:ZDB-GENO-120201-6	Zfish	PMID:19450519
Biological Process	GO:0060047	heart contraction	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:24311987
Biological Process	GO:0007507	heart development	Tnnt2	IMP	MGI:MGI:3692603	Mouse	PMID:9637714
Biological Process	GO:0007507	heart development	Tnnt2	IMP	MGI:MGI:3692598	Mouse	PMID:9637714
Biological Process	GO:0007507	heart development	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:18660518
Biological Process	GO:0001947	heart looping	tnnt2a	IMP	ZFIN:ZDB-GENO-220915-4	Zfish	PMID:33924051
Biological Process	GO:0060218	hematopoietic stem cell differentiation	tnnt2a	IMP	ZFIN:ZDB-GENO-120201-6	Zfish	PMID:19450519
Biological Process	GO:0006874	intracellular calcium ion homeostasis	tnnt2a	IMP	ZFIN:ZDB-GENO-220915-3	Zfish	PMID:33924051
Biological Process	GO:0097535	lymphoid lineage cell migration into thymus	tnnt2a	IMP	ZFIN:ZDB-GENO-980202-1038	Zfish	PMID:22342843
Biological Process	GO:0006936	muscle contraction	Tnnt2	IDA		Mouse	PMID:12832403
Biological Process	GO:0006936	muscle contraction	Tnnt2	IMP		Rat	PMID:16644804|RGD:1580425
Biological Process	GO:0030049	muscle filament sliding	TNNT2	IDA		Human	PMID:12186860
Biological Process	GO:0030049	muscle filament sliding	TNNT2	IDA		Human	PMID:15923195
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	TNNT2	IDA		Human	PMID:10850966
Biological Process	GO:0006809	nitric oxide biosynthetic process	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:21849483
Biological Process	GO:0032781	positive regulation of ATP-dependent activity	TNNT2	IDA		Human	PMID:10850966
Biological Process	GO:0032781	positive regulation of ATP-dependent activity	TNNT2	IDA		Human	PMID:12186860
Biological Process	GO:0048793	pronephros development	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:16753140
Biological Process	GO:0008016	regulation of heart contraction	TNNT2	IMP		Human	PMID:15542288
Biological Process	GO:0008016	regulation of heart contraction	Tnnt2	IMP	MGI:MGI:3692450	Mouse	PMID:11158969
Biological Process	GO:0008016	regulation of heart contraction	Tnnt2	IMP	MGI:MGI:3693250	Mouse	PMID:16326803
Biological Process	GO:0008016	regulation of heart contraction	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-110616-1	Zfish	PMID:21245263
Biological Process	GO:0008016	regulation of heart contraction	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:21245263
Biological Process	GO:0006937	regulation of muscle contraction	Tnnt2	IDA		Rat	PMID:16443664|RGD:1580456
Biological Process	GO:0032972	regulation of muscle filament sliding speed	Tnnt2	IMP		Rat	PMID:10747195|RGD:8554013
Biological Process	GO:0010749	regulation of nitric oxide mediated signal transduction	tnnt2a	IDA		Zfish	PMID:19450519
Biological Process	GO:0009617	response to bacterium	Tnnt2	IEP		Mouse	PMID:23012479
Biological Process	GO:0051592	response to calcium ion	TNNT2	IMP		Human	PMID:8205619
Biological Process	GO:0045214	sarcomere organization	Tnnt2	IMP	MGI:MGI:3692448	Mouse	PMID:10449439
Biological Process	GO:0045214	sarcomere organization	Tnnt2	IMP	MGI:MGI:3692450	Mouse	PMID:10449439
Biological Process	GO:0045214	sarcomere organization	Tnnt2	IMP	MGI:MGI:3692451	Mouse	PMID:10449439
Biological Process	GO:0045214	sarcomere organization	tnnt2a	IMP	ZFIN:ZDB-GENO-980202-320	Zfish	PMID:11967535
Biological Process	GO:0045214	sarcomere organization	tnnt2c	IGI	ZFIN:ZDB-MRPHLNO-110228-1,ZFIN:ZDB-MRPHLNO-110228-2	Zfish	PMID:21245197
Biological Process	GO:0045214	sarcomere organization	tnnt2c	IGI	ZFIN:ZDB-MRPHLNO-110228-1,ZFIN:ZDB-MRPHLNO-110228-3,ZFIN:ZDB-MRPHLNO-110228-4	Zfish	PMID:21245197
Biological Process	GO:0006941	striated muscle contraction	tnnt2a	IMP	ZFIN:ZDB-GENO-980202-320	Zfish	PMID:11967535
Biological Process	GO:0001944	vasculature development	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:22860064
Biological Process	GO:0048845	venous blood vessel morphogenesis	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:19815777
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	TNNT2	IMP		Human	PMID:16754800
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	Tnnt2	IMP	MGI:MGI:3693250	Mouse	PMID:16326803
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	tnnt2a	IMP	ZFIN:ZDB-MRPHLNO-110616-1	Zfish	PMID:21245263
Biological Process	GO:0021591	ventricular system development	tnnt2a	IMP	ZFIN:ZDB-GENO-980202-320	Zfish	PMID:9007238

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern