Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TOLLIP
  • Mouse genes Tollip
  • Rat genes Tollip
  • Zfish genes tollip
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tollip

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005150	interleukin-1, type I receptor binding	Tollip	IPI	RGD:2892	Rat	PMID:19198660|RGD:5508208
Molecular Function	GO:0019900	kinase binding	TOLLIP	IPI	UniProtKB:P51617	Human	PMID:10854325
Molecular Function	GO:0060090	molecular adaptor activity	TOLLIP	IDA		Human	PMID:10854325
Molecular Function	GO:0060090	molecular adaptor activity	TOLLIP	IDA		Human	PMID:27368102
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:P51617-2	Human	PMID:11397809
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O60784	Human	PMID:14563850
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O60784	Human	PMID:15047686
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q15038	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q93062	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q9BQY4	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O60784	Human	PMID:16412388
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O75674	Human	PMID:16412388
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q6ZVM7	Human	PMID:16412388
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:P54253	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q15038	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q9BQY4	Human	PMID:19447967
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O75674	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O43187	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O75674	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:P19525	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q05048	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q86TG7	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q86Y13	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q96S55	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O75674	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q9H492	Human	PMID:25042851
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O60784	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O75553	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q15038	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q96HA8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:P35609	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O60784	Human	PMID:26320582
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O60784	Human	PMID:31263572
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O60784	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q96HA8	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q9BQY4	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:A8MTA8-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O60784-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O75674-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:P20618	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:P35548	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:P86480	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q14764	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q15038	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q16656-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q3LI64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q3LI76	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q3SY46	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q3SYF9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q4VC12	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q5BKX5-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q5VYS4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q6ZVM7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q70EL1-9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q86UA1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q8IUC3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q8N5M4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q92567-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q96B67	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q96E35	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q96NT3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q9BQY4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q9BSU1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q9H305	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q9H668	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q9NWB1-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q9UGI0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q9UHG0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:O60260-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q14203-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TOLLIP	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Tollip	IPI	UniProtKB:Q61730|UniProtKB:Q62406	Mouse	MGI:MGI:1889886|PMID:10854325
Molecular Function	GO:0005515	protein binding	Tollip	IPI	UniProtKB:O88746	Mouse	MGI:MGI:3843439|PMID:14563850
Molecular Function	GO:0005515	protein binding	Tollip	IPI	RGD:1321254	Rat	PMID:19198660|RGD:5508208
Molecular Function	GO:0032183	SUMO binding	Tollip	IPI	RGD:1306919	Rat	PMID:19198660|RGD:5508208
Molecular Function	GO:0035325	Toll-like receptor binding	TOLLIP	IPI	UniProtKB:O00206	Human	PMID:11441107
Molecular Function	GO:0035325	Toll-like receptor binding	TOLLIP	IPI	UniProtKB:O60603	Human	PMID:11441107
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	Tollip	IPI	RGD:3926	Rat	PMID:19198660|RGD:5508208
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Tollip	IPI	RGD:1307843	Rat	PMID:19198660|RGD:5508208
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Tollip	IPI	RGD:71056	Rat	PMID:19198660|RGD:5508208
Cellular Component	GO:0070062	extracellular exosome	TOLLIP	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	TOLLIP	HDA		Human	PMID:23533145
Cellular Component	GO:0016604	nuclear body	Tollip	IDA		Rat	PMID:19198660|RGD:5508208
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Tollip	IDA		Rat	PMID:19198660|RGD:5508208
Cellular Component	GO:0032991	protein-containing complex	TOLLIP	IDA		Human	PMID:10854325
Cellular Component	GO:0032991	protein-containing complex	Tollip	IDA		Mouse	MGI:MGI:1889886|PMID:10854325
Biological Process	GO:0030855	epithelial cell differentiation	TOLLIP	IEP		Human	PMID:21492153
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	TOLLIP	IDA		Human	PMID:10854325
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	Tollip	IDA		Mouse	MGI:MGI:1889886|PMID:10854325
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	tollip	IMP	ZFIN:ZDB-MRPHLNO-151109-13	Zfish	PMID:26110841
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	tollip	IMP	ZFIN:ZDB-MRPHLNO-151109-12	Zfish	PMID:26110841
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	tollip	IMP	ZFIN:ZDB-MRPHLNO-151109-11	Zfish	PMID:26110841
Biological Process	GO:0016310	phosphorylation	TOLLIP	IDA		Human	PMID:1085432
Biological Process	GO:0033235	positive regulation of protein sumoylation	Tollip	IDA		Rat	PMID:19198660|RGD:5508208
Biological Process	GO:0036010	protein localization to endosome	TOLLIP	IDA		Human	PMID:16412388
Biological Process	GO:0007165	signal transduction	TOLLIP	IPI	UniProtKB:O60603	Human	PMID:11441107

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern