Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TOMM70
  • Mouse genes Tomm70a
  • Rat genes Tomm70
  • Zfish genes tomm70a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tomm70a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0060090	molecular adaptor activity	TOMM70	IDA		Human	PMID:20628368
Molecular Function	GO:0140677	molecular function activator activity	TOMM70	IDA		Human	PMID:20628368
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P07900	Human	PMID:12526792
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P07900,UniProtKB:Q14653,UniProtKB:Q9UHD2|UniProtKB:Q15628|UniProtKB:Q7Z434|UniProtKB:Q86WV6|UniProtKB:Q9Y4K3	Human	PMID:20628368
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P23396	Human	PMID:23911537
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P07900,UniProtKB:Q07812,UniProtKB:Q14653	Human	PMID:25609812
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P0DTD2	Human	PMID:32353859
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P0DTD2	Human	PMID:32728199
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P59636	Human	PMID:32728199
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P0DTD2	Human	PMID:33060197
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P0DTD2|UniProtKB:P59636	Human	PMID:33060197
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P59636	Human	PMID:33060197
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P0DTD2	Human	PMID:33845483
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P07900	Human	PMID:33990585
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P0DTD2	Human	PMID:33990585
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P0DTD2	Human	PMID:34232536
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P0DTD2	Human	PMID:34502139
Molecular Function	GO:0005515	protein binding	TOMM70	IPI	UniProtKB:P0DTD2	Human	PMID:34942634
Molecular Function	GO:0005515	protein binding	Tomm70a	IPI	UniProtKB:Q8K443	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Tomm70	IPI	RGD:1303260|RGD:708467	Rat	PMID:11956321|RGD:1303951
Cellular Component	GO:0070062	extracellular exosome	TOMM70	HDA		Human	PMID:18570454
Cellular Component	GO:0016020	membrane	TOMM70	HDA		Human	PMID:19946888
Cellular Component	GO:0031966	mitochondrial membrane	TOMM70	IDA		Human	PMID:20628368
Cellular Component	GO:0005741	mitochondrial outer membrane	Tomm70	IDA		Rat	PMID:11956321|RGD:1303951
Cellular Component	GO:0005739	mitochondrion	TOMM70	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	TOMM70	IDA		Human	PMID:20531390
Cellular Component	GO:0005739	mitochondrion	TOMM70	IDA		Human	PMID:20628368
Cellular Component	GO:0005739	mitochondrion	TOMM70	IDA		Human	PMID:25609812
Cellular Component	GO:0005739	mitochondrion	Tomm70a	IDA		Mouse	PMID:23303939
Cellular Component	GO:0005739	mitochondrion	Tomm70a	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Tomm70a	HDA		Mouse	PMID:18614015
Biological Process	GO:0002218	activation of innate immune response	TOMM70	IDA		Human	PMID:20628368
Biological Process	GO:0098586	cellular response to virus	TOMM70	IDA		Human	PMID:25609812
Biological Process	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	Tomm70	IMP		Rat	PMID:25022898|RGD:13464131
Biological Process	GO:0002230	positive regulation of defense response to virus by host	TOMM70	IDA		Human	PMID:20628368
Biological Process	GO:0032728	positive regulation of interferon-beta production	TOMM70	IDA		Human	PMID:20628368
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	Tomm70	IMP		Rat	PMID:11956321|RGD:1303951
Biological Process	GO:0006626	protein targeting to mitochondrion	Tomm70	IMP		Rat	PMID:19401463|RGD:13838795
Biological Process	GO:0042981	regulation of apoptotic process	TOMM70	IDA		Human	PMID:25609812
Biological Process	GO:0097068	response to thyroxine	Tomm70	IEP		Rat	PMID:10582581|RGD:11522362
Biological Process	GO:0055015	ventricular cardiac muscle cell development	tomm70a	IMP	ZFIN:ZDB-MRPHLNO-170522-1	Zfish	PMID:25022898

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern