Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TOP1
  • Mouse genes Top1
  • Rat genes Top1
  • Zfish genes top1a,top1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Top1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	TOP1	IMP		Human	PMID:8631793
Molecular Function	GO:0005524	ATP binding	TOP1	IMP		Human	PMID:9611241
Molecular Function	GO:0003682	chromatin binding	TOP1	IDA		Human	PMID:9049244
Molecular Function	GO:0031490	chromatin DNA binding	Top1	IDA		Rat	PMID:1332866|RGD:1580856
Molecular Function	GO:0003677	DNA binding	TOP1	IMP		Human	PMID:10497031
Molecular Function	GO:0003677	DNA binding	TOP1	EXP		Human	PMID:11283003
Molecular Function	GO:0003677	DNA binding	TOP1	IDA		Human	PMID:17355975
Molecular Function	GO:0003677	DNA binding	Top1	IDA		Rat	PMID:10469141|RGD:2317063
Molecular Function	GO:0008301	DNA binding, bending	TOP1	EXP		Human	PMID:11283003
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	TOP1	IDA		Human	PMID:14594810
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	TOP1	IMP		Human	PMID:14654701
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	TOP1	IMP		Human	PMID:17355975
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	TOP1	IMP		Human	PMID:8567649
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	TOP1	IMP		Human	PMID:8631793
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	TOP1	IMP		Human	PMID:8631794
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	TOP1	IMP		Human	PMID:9611241
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	Top1	IDA		Mouse	PMID:9094096
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	Top1	IDA		Mouse	PMID:16261531
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	Top1	IDA		Mouse	PMID:7842491
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	Top1	IDA		Rat	PMID:1332866|RGD:1580856
Molecular Function	GO:0003690	double-stranded DNA binding	TOP1	IMP		Human	PMID:8631794
Molecular Function	GO:0005515	protein binding	TOP1	IPI	UniProtKB:Q9NS56	Human	PMID:10352183
Molecular Function	GO:0005515	protein binding	TOP1	IPI	UniProtKB:Q9BX70	Human	PMID:12878161
Molecular Function	GO:0005515	protein binding	TOP1	IPI	UniProtKB:Q9H0C5	Human	PMID:12878161
Molecular Function	GO:0005515	protein binding	TOP1	IPI	UniProtKB:P00519	Human	PMID:15448168
Molecular Function	GO:0005515	protein binding	TOP1	IPI	UniProtKB:Q99801	Human	PMID:17234752
Molecular Function	GO:0005515	protein binding	TOP1	IPI	UniProtKB:P01106	Human	PMID:17314511
Molecular Function	GO:0005515	protein binding	TOP1	IPI	UniProtKB:P01106	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	TOP1	IPI	UniProtKB:Q03468	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	TOP1	IPI	UniProtKB:P42768	Human	PMID:29248492
Molecular Function	GO:0005515	protein binding	TOP1	IPI	UniProtKB:P19338	Human	PMID:8567649
Molecular Function	GO:0019904	protein domain specific binding	TOP1	IPI	UniProtKB:Q07955	Human	PMID:9611241
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TOP1	IMP		Human	PMID:9611241
Molecular Function	GO:0044877	protein-containing complex binding	Top1	IDA		Rat	PMID:2851418|RGD:2317067
Molecular Function	GO:0003723	RNA binding	TOP1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	TOP1	HDA		Human	PMID:22681889
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	TOP1	IDA		Human	PMID:22904072
Molecular Function	GO:0003697	single-stranded DNA binding	TOP1	IMP		Human	PMID:8631794
Molecular Function	GO:0097100	supercoiled DNA binding	TOP1	IMP		Human	PMID:14654701
Molecular Function	GO:0097100	supercoiled DNA binding	TOP1	IMP		Human	PMID:8631793
Molecular Function	GO:0097100	supercoiled DNA binding	TOP1	IMP		Human	PMID:9611241
Cellular Component	GO:0005737	cytoplasm	Top1	IDA		Mouse	PMID:16261531
Cellular Component	GO:0001651	dense fibrillar component	Top1	IDA		Rat	PMID:11170002|RGD:8693630
Cellular Component	GO:0001650	fibrillar center	TOP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001650	fibrillar center	Top1	IDA		Rat	PMID:17587596|RGD:2301351
Cellular Component	GO:0001673	male germ cell nucleus	Top1	IDA		Mouse	PMID:9094096
Cellular Component	GO:0000228	nuclear chromosome	TOP1	IDA		Human	PMID:9049244
Cellular Component	GO:0005730	nucleolus	TOP1	IMP		Human	PMID:14654701
Cellular Component	GO:0005730	nucleolus	TOP1	IDA		Human	PMID:9049244
Cellular Component	GO:0005654	nucleoplasm	TOP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TOP1	IMP		Human	PMID:14654701
Cellular Component	GO:0005654	nucleoplasm	TOP1	IDA		Human	PMID:9049244
Cellular Component	GO:0005634	nucleus	TOP1	IDA		Human	PMID:11016921
Cellular Component	GO:0005634	nucleus	TOP1	HDA		Human	PMID:16791210
Cellular Component	GO:0005634	nucleus	TOP1	IDA		Human	PMID:9049244
Cellular Component	GO:0005634	nucleus	Top1	IDA		Mouse	PMID:8943335
Cellular Component	GO:0005634	nucleus	Top1	IDA		Mouse	PMID:16261531
Cellular Component	GO:0005634	nucleus	Top1	IDA		Rat	PMID:1332866|RGD:1580856
Cellular Component	GO:0000932	P-body	TOP1	IDA		Human	PMID:12878161
Cellular Component	GO:0043204	perikaryon	Top1	IDA		Mouse	PMID:16261531
Cellular Component	GO:0032993	protein-DNA complex	TOP1	IMP		Human	PMID:10497031
Biological Process	GO:0031100	animal organ regeneration	Top1	IEP		Rat	PMID:1332866|RGD:1580856
Biological Process	GO:0071373	cellular response to luteinizing hormone stimulus	Top1	IEP		Rat	PMID:2822514|RGD:2317068
Biological Process	GO:0006338	chromatin remodeling	TOP1	IMP		Human	PMID:22904072
Biological Process	GO:0032922	circadian regulation of gene expression	TOP1	IMP		Human	PMID:22904072
Biological Process	GO:0007623	circadian rhythm	TOP1	IEP		Human	PMID:22904072
Biological Process	GO:0006260	DNA replication	Top1	IMP		Mouse	PMID:11756244
Biological Process	GO:0006265	DNA topological change	TOP1	IDA		Human	PMID:14594810
Biological Process	GO:0006265	DNA topological change	TOP1	IMP		Human	PMID:14654701
Biological Process	GO:0006265	DNA topological change	TOP1	IMP		Human	PMID:8567649
Biological Process	GO:0006265	DNA topological change	TOP1	IMP		Human	PMID:8631793
Biological Process	GO:0006265	DNA topological change	TOP1	IMP		Human	PMID:8631794
Biological Process	GO:0006265	DNA topological change	TOP1	IMP		Human	PMID:9611241
Biological Process	GO:0006265	DNA topological change	Top1	IDA		Mouse	PMID:16261531
Biological Process	GO:0006265	DNA topological change	Top1	IDA		Mouse	PMID:7842491
Biological Process	GO:0006265	DNA topological change	Top1	IDA		Rat	PMID:1332866|RGD:1580856
Biological Process	GO:0040016	embryonic cleavage	Top1	IMP	MGI:MGI:2678314	Mouse	PMID:8943335
Biological Process	GO:0018105	peptidyl-serine phosphorylation	TOP1	IMP		Human	PMID:9611241
Biological Process	GO:0051591	response to cAMP	Top1	IEP		Rat	PMID:2822514|RGD:2317068
Biological Process	GO:0010332	response to gamma radiation	Top1	IEP		Rat	PMID:2853856|RGD:2317066
Biological Process	GO:0009266	response to temperature stimulus	Top1	IEP		Rat	PMID:9076473|RGD:2317065
Biological Process	GO:0009410	response to xenobiotic stimulus	TOP1	IEP		Human	PMID:16127745
Biological Process	GO:0009303	rRNA transcription	Top1	IMP		Rat	PMID:3033639|RGD:2317069

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern