Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Top2a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TOP2A
- Mouse genes Top2a
- Rat genes Top2a
- Zfish genes top2a
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Top2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Top2a	IDA		Rat	PMID:11334111\|RGD:1580614
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	TOP2A	IDA		Human	PMID:12079377
Molecular Function	GO:0003682	chromatin binding	TOP2A	IDA		Human	PMID:9049244
Molecular Function	GO:0003682	chromatin binding	Top2a	IDA		Rat	PMID:11334111\|RGD:1580614
Molecular Function	GO:0003677	DNA binding	TOP2A	IDA		Human	PMID:10788521
Molecular Function	GO:0003677	DNA binding	TOP2A	IDA		Human	PMID:12079377
Molecular Function	GO:0003677	DNA binding	TOP2A	IDA		Human	PMID:9049244
Molecular Function	GO:0003677	DNA binding	Top2a	IDA		Rat	PMID:11334111\|RGD:1580614
Molecular Function	GO:0008301	DNA binding, bending	TOP2A	IDA		Human	PMID:22323612
Molecular Function	GO:0003916	DNA topoisomerase activity	Top2a	IDA		Rat	PMID:11334111\|RGD:1580614
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	TOP2A	IMP		Human	PMID:12711669
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	TOP2A	IDA		Human	PMID:16611985
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Top2a	IDA		Mouse	MGI:MGI:51613\|PMID:1331984
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Top2a	IDA		Mouse	PMID:7842491
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Top2a	IDA		Mouse	PMID:9094096
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Top2a	IDA		Mouse	PMID:1331984
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Top2a	IGI	SGD:S000005032	Mouse	PMID:1331984
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Top2a	IGI	SGD:S000005032	Mouse	PMID:7937150
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Top2a	IDA		Rat	PMID:11334111\|RGD:1580614
Molecular Function	GO:0000287	magnesium ion binding	TOP2A	IDA		Human	PMID:22323612
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:P04637	Human	PMID:10666337
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:P62258	Human	PMID:10788521
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:O76075	Human	PMID:10959840
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:Q13547	Human	PMID:11062478
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:Q92769	Human	PMID:11062478
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:Q13547	Human	PMID:11136718
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:Q08211	Human	PMID:12711669
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:P38398	Human	PMID:15965487
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:Q05655	Human	PMID:16611985
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:O15162	Human	PMID:17567603
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:P35222	Human	PMID:17983804
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:Q53H47	Human	PMID:18790802
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:Q53H47	Human	PMID:19390626
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:Q53H47	Human	PMID:20457750
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:O60318	Human	PMID:23652018
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:O14497-1	Human	PMID:23698369
Molecular Function	GO:0005515	protein binding	TOP2A	IPI	UniProtKB:Q03468	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	Top2a	IPI	UniProtKB:Q3TKT4	Mouse	MGI:MGI:5499063\|PMID:23698369
Molecular Function	GO:0005515	protein binding	Top2a	IPI	PR:A0A1D9BZF0	Mouse	PMID:31839538
Molecular Function	GO:0046982	protein heterodimerization activity	TOP2A	IPI	UniProtKB:Q02880	Human	PMID:10473615
Molecular Function	GO:0042803	protein homodimerization activity	TOP2A	IPI	UniProtKB:P11388	Human	PMID:10473615
Molecular Function	GO:0005080	protein kinase C binding	TOP2A	IPI	UniProtKB:Q05655	Human	PMID:16611985
Molecular Function	GO:0003723	RNA binding	TOP2A	HDA		Human	PMID:22681889
Molecular Function	GO:0043565	sequence-specific DNA binding	Top2a	IDA		Rat	PMID:11334111\|RGD:1580614
Molecular Function	GO:0043130	ubiquitin binding	TOP2A	IMP		Human	PMID:15965487
Cellular Component	GO:0005814	centriole	TOP2A	IDA		Human	PMID:9049244
Cellular Component	GO:0000775	chromosome, centromeric region	Top2a	IDA		Mouse	PMID:26919979
Cellular Component	GO:0000793	condensed chromosome	Top2a	IMP		Mouse	PMID:21795393
Cellular Component	GO:0000793	condensed chromosome	Top2a	IDA		Mouse	PMID:11835579
Cellular Component	GO:0005737	cytoplasm	TOP2A	IDA		Human	PMID:9155056
Cellular Component	GO:0009330	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	TOP2A	IDA		Human	PMID:10473615
Cellular Component	GO:0009330	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	Top2a	IDA		Rat	PMID:11334111\|RGD:1580614
Cellular Component	GO:0001673	male germ cell nucleus	Top2a	IDA		Mouse	PMID:9094096
Cellular Component	GO:0000228	nuclear chromosome	TOP2A	IDA		Human	PMID:9049244
Cellular Component	GO:0005730	nucleolus	TOP2A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	TOP2A	IDA		Human	PMID:17567603
Cellular Component	GO:0005730	nucleolus	TOP2A	IDA		Human	PMID:8299728
Cellular Component	GO:0005730	nucleolus	TOP2A	IDA		Human	PMID:9155056
Cellular Component	GO:0005730	nucleolus	Top2a	IDA		Mouse	PMID:11835579
Cellular Component	GO:0005730	nucleolus	Top2a	IDA		Rat	PMID:11170002\|RGD:8693630
Cellular Component	GO:0005654	nucleoplasm	TOP2A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TOP2A	IDA		Human	PMID:8299728
Cellular Component	GO:0005654	nucleoplasm	TOP2A	IDA		Human	PMID:9049244
Cellular Component	GO:0005634	nucleus	TOP2A	IDA		Human	PMID:10788521
Cellular Component	GO:0005634	nucleus	TOP2A	IDA		Human	PMID:10959840
Cellular Component	GO:0005634	nucleus	TOP2A	IDA		Human	PMID:16611985
Cellular Component	GO:0005634	nucleus	TOP2A	IDA		Human	PMID:9155056
Cellular Component	GO:0005634	nucleus	Top2a	IDA		Mouse	PMID:25961503
Cellular Component	GO:0005634	nucleus	Top2a	IDA		Mouse	PMID:9224616
Cellular Component	GO:0005634	nucleus	Top2a	IDA		Rat	PMID:11334111\|RGD:1580614
Cellular Component	GO:0005634	nucleus	Top2a	IDA		Rat	PMID:8390253\|RGD:61772
Cellular Component	GO:0032991	protein-containing complex	TOP2A	IDA		Human	PMID:16611985
Cellular Component	GO:1990904	ribonucleoprotein complex	TOP2A	IDA		Human	PMID:12711669
Biological Process	GO:0007568	aging	Top2a	IEP		Rat	PMID:19204916\|RGD:2315123
Biological Process	GO:0031100	animal organ regeneration	top2a	IMP	ZFIN:ZDB-GENO-090727-2	Zfish	PMID:19380487
Biological Process	GO:0031100	animal organ regeneration	top2a	IMP	ZFIN:ZDB-GENO-090727-1	Zfish	PMID:19380487
Biological Process	GO:0030263	apoptotic chromosome condensation	TOP2A	IDA		Human	PMID:10959840
Biological Process	GO:0007420	brain development	Top2a	IEP		Rat	PMID:8008235\|RGD:8693613
Biological Process	GO:0021707	cerebellar granule cell differentiation	Top2a	IEP		Rat	PMID:11170002\|RGD:8693630
Biological Process	GO:0021702	cerebellar Purkinje cell differentiation	Top2a	IEP		Rat	PMID:11170002\|RGD:8693630
Biological Process	GO:0030261	chromosome condensation	Top2a	IMP		Mouse	PMID:11835580
Biological Process	GO:0007059	chromosome segregation	TOP2A	IMP		Human	PMID:11136718
Biological Process	GO:0007059	chromosome segregation	TOP2A	IMP		Human	PMID:15456904
Biological Process	GO:0007059	chromosome segregation	TOP2A	IMP		Human	PMID:15965487
Biological Process	GO:0007059	chromosome segregation	Top2a	IMP		Mouse	PMID:11835580
Biological Process	GO:0007059	chromosome segregation	Top2a	IDA		Mouse	PMID:7842491
Biological Process	GO:0007059	chromosome segregation	top2a	IMP	ZFIN:ZDB-GENO-090714-1	Zfish	PMID:19380487
Biological Process	GO:0007059	chromosome segregation	top2a	IMP	ZFIN:ZDB-MRPHLNO-090713-1	Zfish	PMID:19380487
Biological Process	GO:0006974	DNA damage response	TOP2A	IDA		Human	PMID:16611985
Biological Process	GO:0006266	DNA ligation	TOP2A	IDA		Human	PMID:15491148
Biological Process	GO:0006265	DNA topological change	TOP2A	IMP		Human	PMID:12711669
Biological Process	GO:0006265	DNA topological change	TOP2A	IDA		Human	PMID:22323612
Biological Process	GO:0006265	DNA topological change	Top2a	IDA		Mouse	PMID:9224616
Biological Process	GO:0006265	DNA topological change	Top2a	IDA		Mouse	PMID:1331984
Biological Process	GO:0006265	DNA topological change	Top2a	IDA		Rat	PMID:11334111\|RGD:1580614
Biological Process	GO:0040016	embryonic cleavage	Top2a	IMP		Mouse	PMID:11835580
Biological Process	GO:0007143	female meiotic nuclear division	Top2a	IMP		Mouse	PMID:25961503
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Top2a	IMP		Mouse	PMID:24029230
Biological Process	GO:1905463	negative regulation of DNA duplex unwinding	TOP2A	IMP		Human	PMID:12711669
Biological Process	GO:0043065	positive regulation of apoptotic process	TOP2A	IDA		Human	PMID:16611985
Biological Process	GO:0045870	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	TOP2A	IMP		Human	PMID:16712776
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Top2a	IMP		Mouse	PMID:1683482
Biological Process	GO:0042752	regulation of circadian rhythm	Top2a	IMP		Mouse	MGI:MGI:5613450\|PMID:24321095
Biological Process	GO:0010212	response to ionizing radiation	Top2a	IEP		Rat	PMID:22965249\|RGD:13432139
Biological Process	GO:0071107	response to parathyroid hormone	Top2a	IEP		Rat	PMID:10709994\|RGD:2315136
Biological Process	GO:0009410	response to xenobiotic stimulus	Top2a	IEP		Rat	PMID:14766721\|RGD:2315135
Biological Process	GO:0009410	response to xenobiotic stimulus	Top2a	IEP		Rat	PMID:15033592\|RGD:2315134

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.