Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TOP2B
  • Mouse genes Top2b
  • Rat genes
  • Zfish genes top2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Top2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	TOP2B	IDA		Human	PMID:9049244
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	TOP2B	IDA		Human	PMID:10684600
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	TOP2B	IMP		Human	PMID:31409799
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	TOP2B	IMP		Human	PMID:32128574
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Top2b	IMP		Mouse	MGI:MGI:6362312|PMID:31409799
Molecular Function	GO:0005515	protein binding	TOP2B	IPI	UniProtKB:P11388	Human	PMID:10473615
Molecular Function	GO:0005515	protein binding	TOP2B	IPI	UniProtKB:P04637	Human	PMID:10666337
Molecular Function	GO:0005515	protein binding	TOP2B	IPI	UniProtKB:Q13547	Human	PMID:11062478
Molecular Function	GO:0005515	protein binding	TOP2B	IPI	UniProtKB:Q92769	Human	PMID:11062478
Molecular Function	GO:0005515	protein binding	TOP2B	IPI	UniProtKB:Q13547	Human	PMID:11136718
Molecular Function	GO:0005515	protein binding	TOP2B	IPI	UniProtKB:Q05655	Human	PMID:16611985
Molecular Function	GO:0005515	protein binding	TOP2B	IPI	UniProtKB:O15162	Human	PMID:17567603
Molecular Function	GO:0005515	protein binding	Top2b	IPI	UniProtKB:Q9WVE0	Mouse	MGI:MGI:4946885|PMID:21186367
Cellular Component	GO:0005829	cytosol	TOP2B	IDA		Human	PMID:9049244
Cellular Component	GO:0000792	heterochromatin	TOP2B	IDA		Human	PMID:9049244
Cellular Component	GO:0005730	nucleolus	TOP2B	IDA		Human	PMID:8299728
Cellular Component	GO:0005730	nucleolus	TOP2B	IDA		Human	PMID:9155056
Cellular Component	GO:0005654	nucleoplasm	TOP2B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TOP2B	IDA		Human	PMID:9049244
Cellular Component	GO:0005634	nucleus	TOP2B	IDA		Human	PMID:17567603
Cellular Component	GO:0005634	nucleus	TOP2B	IDA		Human	PMID:9049244
Cellular Component	GO:0005634	nucleus	TOP2B	IDA		Human	PMID:9155056
Cellular Component	GO:0005634	nucleus	Top2b	IDA		Mouse	PMID:9224616
Cellular Component	GO:0005634	nucleus	Top2b	IDA		Mouse	PMID:11835579
Biological Process	GO:0007412	axon target recognition	top2b	IMP	ZFIN:ZDB-GENO-110729-5	Zfish	PMID:21610027
Biological Process	GO:0007409	axonogenesis	Top2b	IMP	MGI:MGI:2179201	Mouse	PMID:10615047
Biological Process	GO:0030183	B cell differentiation	TOP2B	IMP		Human	PMID:31409799
Biological Process	GO:0030183	B cell differentiation	TOP2B	IMP		Human	PMID:32128574
Biological Process	GO:0030183	B cell differentiation	Top2b	IMP		Mouse	MGI:MGI:6362312|PMID:31409799
Biological Process	GO:0006265	DNA topological change	TOP2B	IDA		Human	PMID:10684600
Biological Process	GO:0030900	forebrain development	Top2b	IMP	MGI:MGI:3521923	Mouse	PMID:12773624
Biological Process	GO:0048884	neuromast development	top2b	IMP	ZFIN:ZDB-MRPHLNO-200916-1	Zfish	PMID:31198993
Biological Process	GO:0048884	neuromast development	top2b	IMP	ZFIN:ZDB-MRPHLNO-200916-2	Zfish	PMID:31198993
Biological Process	GO:0001764	neuron migration	Top2b	IMP	MGI:MGI:3521923	Mouse	PMID:12773624
Biological Process	GO:0045870	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	TOP2B	IMP		Human	PMID:16712776
Biological Process	GO:0010842	retina layer formation	top2b	IMP	ZFIN:ZDB-GENO-110729-5	Zfish	PMID:21610027
Biological Process	GO:0031290	retinal ganglion cell axon guidance	top2b	IMP	ZFIN:ZDB-GENO-110729-5	Zfish	PMID:21610027

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern