Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TOP3A
  • Mouse genes Top3a
  • Rat genes Top3a
  • Zfish genes top3a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Top3a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	TOP3A	IDA		Human	PMID:20445207
Molecular Function	GO:0005515	protein binding	TOP3A	IPI	UniProtKB:P54132	Human	PMID:10728666
Molecular Function	GO:0005515	protein binding	TOP3A	IPI	UniProtKB:P54132	Human	PMID:15775963
Molecular Function	GO:0005515	protein binding	TOP3A	IPI	UniProtKB:Q9H9A7	Human	PMID:15775963
Molecular Function	GO:0005515	protein binding	TOP3A	IPI	UniProtKB:Q9H9A7	Human	PMID:16537486
Molecular Function	GO:0005515	protein binding	TOP3A	IPI	UniProtKB:P54132	Human	PMID:20360068
Molecular Function	GO:0005515	protein binding	TOP3A	IPI	UniProtKB:Q9H9A7	Human	PMID:20360068
Molecular Function	GO:0005515	protein binding	TOP3A	IPI	UniProtKB:P54132	Human	PMID:20711169
Molecular Function	GO:0005515	protein binding	TOP3A	IPI	UniProtKB:Q9H9A7	Human	PMID:20711169
Molecular Function	GO:0005515	protein binding	TOP3A	IPI	UniProtKB:Q9H9A7	Human	PMID:20826342
Molecular Function	GO:0005515	protein binding	TOP3A	IPI	UniProtKB:P54132	Human	PMID:23509288
Molecular Function	GO:0005515	protein binding	TOP3A	IPI	UniProtKB:Q9H9A7	Human	PMID:24509834
Molecular Function	GO:0005515	protein binding	TOP3A	IPI	UniProtKB:P54132	Human	PMID:26496610
Molecular Function	GO:0003697	single-stranded DNA binding	TOP3A	IDA		Human	PMID:29290614
Cellular Component	GO:0016605	PML body	TOP3A	IDA		Human	PMID:10728666
Cellular Component	GO:0031422	RecQ family helicase-topoisomerase III complex	TOP3A	IPI		Human	PMID:24984776
Biological Process	GO:0051304	chromosome separation	TOP3A	IMP		Human	PMID:30057030
Biological Process	GO:0006265	DNA topological change	TOP3A	IDA		Human	PMID:20445207
Biological Process	GO:0000724	double-strand break repair via homologous recombination	TOP3A	IDA		Human	PMID:23543748
Biological Process	GO:0032042	mitochondrial DNA metabolic process	TOP3A	IMP		Human	PMID:29290614
Biological Process	GO:0071139	resolution of recombination intermediates	TOP3A	IDA		Human	PMID:23543748

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern