Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TOPBP1
  • Mouse genes Topbp1
  • Rat genes Topbp1
  • Zfish genes topbp1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Topbp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TOPBP1	IPI	UniProtKB:Q92547	Human	PMID:17006541
Molecular Function	GO:0005515	protein binding	TOPBP1	IPI	UniProtKB:P29590-5	Human	PMID:12773567
Molecular Function	GO:0005515	protein binding	TOPBP1	IPI	UniProtKB:P03120	Human	PMID:17006541
Molecular Function	GO:0005515	protein binding	TOPBP1	IPI	UniProtKB:P31749	Human	PMID:17006541
Molecular Function	GO:0005515	protein binding	TOPBP1	IPI	UniProtKB:Q01094	Human	PMID:17006541
Molecular Function	GO:0005515	protein binding	TOPBP1	IPI	UniProtKB:O75419	Human	PMID:17887956
Molecular Function	GO:0005515	protein binding	TOPBP1	IPI	UniProtKB:Q9UGU0	Human	PMID:17913746
Molecular Function	GO:0005515	protein binding	TOPBP1	IPI	UniProtKB:Q13105	Human	PMID:18923429
Molecular Function	GO:0005515	protein binding	TOPBP1	IPI	UniProtKB:Q7Z2Z1	Human	PMID:20080954
Molecular Function	GO:0005515	protein binding	TOPBP1	IPI	UniProtKB:Q9BSD3	Human	PMID:21659603
Cellular Component	GO:0015629	actin cytoskeleton	TOPBP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070532	BRCA1-B complex	TOPBP1	IPI		Human	PMID:16391231
Cellular Component	GO:0005694	chromosome	TOPBP1	IDA		Human	PMID:21659603
Cellular Component	GO:0005694	chromosome	Topbp1	IDA		Mouse	MGI:MGI:5319701|PMID:22549958
Cellular Component	GO:0000794	condensed nuclear chromosome	Topbp1	IDA		Mouse	PMID:14718568
Cellular Component	GO:0001673	male germ cell nucleus	Topbp1	IDA		Mouse	PMID:17696610
Cellular Component	GO:0016604	nuclear body	TOPBP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TOPBP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	topbp1	IDA		Zfish	PMID:26131719
Cellular Component	GO:0005886	plasma membrane	TOPBP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016605	PML body	TOPBP1	IDA		Human	PMID:12773567
Biological Process	GO:0060216	definitive hemopoiesis	topbp1	IMP	ZFIN:ZDB-GENO-151215-1	Zfish	PMID:26131719
Biological Process	GO:0006974	DNA damage response	TOPBP1	IDA		Human	PMID:12773567
Biological Process	GO:0006974	DNA damage response	topbp1	IMP	ZFIN:ZDB-GENO-151215-1	Zfish	PMID:26131719
Biological Process	GO:1902165	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	topbp1	IMP	ZFIN:ZDB-GENO-151215-1	Zfish	PMID:26131719
Biological Process	GO:0010212	response to ionizing radiation	TOPBP1	IDA		Human	PMID:12773567

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern