Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TOPORS
  • Mouse genes Topors
  • Rat genes Topors
  • Zfish genes toporsa,toporsb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Topors

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003823	antigen binding	TOPORS	IPI	UniProtKB:P04637	Human	PMID:10415337
Molecular Function	GO:0003677	DNA binding	TOPORS	IDA		Human	PMID:11278651
Molecular Function	GO:0044547	DNA topoisomerase binding	TOPORS	IPI	UniProtKB:P11387	Human	PMID:10352183
Molecular Function	GO:0005515	protein binding	TOPORS	IPI	UniProtKB:P03132	Human	PMID:11842245
Molecular Function	GO:0005515	protein binding	TOPORS	IPI	UniProtKB:P63165	Human	PMID:14516784
Molecular Function	GO:0005515	protein binding	TOPORS	IPI	UniProtKB:P63279	Human	PMID:14516784
Molecular Function	GO:0005515	protein binding	TOPORS	IPI	UniProtKB:Q96ST3	Human	PMID:17803295
Molecular Function	GO:0005515	protein binding	TOPORS	IPI	UniProtKB:Q99801	Human	PMID:18077445
Molecular Function	GO:0005515	protein binding	TOPORS	IPI	UniProtKB:P53350	Human	PMID:19473992
Molecular Function	GO:0005515	protein binding	TOPORS	IPI	UniProtKB:Q14164	Human	PMID:20188669
Molecular Function	GO:0005515	protein binding	Topors	IPI	PR:Q9QWH1	Mouse	PMID:15735665
Molecular Function	GO:0005515	protein binding	Topors	IPI	PR:P02340	Mouse	PMID:15735665
Molecular Function	GO:0005515	protein binding	toporsb	IPI	ZFIN:ZDB-GENE-090618-1	Zfish	PMID:25190811
Molecular Function	GO:0005515	protein binding	toporsb	IPI	ZFIN:ZDB-GENE-050306-15	Zfish	PMID:25190811
Molecular Function	GO:0019789	SUMO transferase activity	TOPORS	EXP		Human	PMID:17803295
Molecular Function	GO:0019789	SUMO transferase activity	TOPORS	IDA		Human	PMID:17803295
Molecular Function	GO:0019789	SUMO transferase activity	TOPORS	IMP		Human	PMID:19473992
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TOPORS	IDA		Human	PMID:15247280
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TOPORS	IDA		Human	PMID:18077445
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TOPORS	IMP		Human	PMID:19473992
Cellular Component	GO:0005814	centriole	TOPORS	IDA		Human	PMID:21159800
Cellular Component	GO:0005814	centriole	TOPORS	IDA		Human	PMID:26872363
Cellular Component	GO:0036064	ciliary basal body	TOPORS	IDA		Human	PMID:21159800
Cellular Component	GO:0036064	ciliary basal body	Topors	IDA		Mouse	MGI:MGI:4939557|PMID:21159800
Cellular Component	GO:0000930	gamma-tubulin complex	TOPORS	IDA		Human	PMID:21159800
Cellular Component	GO:0016607	nuclear speck	TOPORS	IDA		Human	PMID:14516784
Cellular Component	GO:0005654	nucleoplasm	TOPORS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TOPORS	IDA		Human	PMID:18077445
Cellular Component	GO:0005634	nucleus	Topors	IDA		Mouse	MGI:MGI:4939557|PMID:21159800
Cellular Component	GO:0005634	nucleus	Topors	IDA		Mouse	PMID:15735665
Cellular Component	GO:0032391	photoreceptor connecting cilium	TOPORS	IDA		Human	PMID:21159800
Cellular Component	GO:0032391	photoreceptor connecting cilium	Topors	IDA		Mouse	MGI:MGI:4939557|PMID:21159800
Cellular Component	GO:0016605	PML body	TOPORS	IDA		Human	PMID:21159800
Cellular Component	GO:0016605	PML body	TOPORS	IDA		Human	PMID:20188669
Cellular Component	GO:0000922	spindle pole	TOPORS	IDA		Human	PMID:21159800
Cellular Component	GO:0000151	ubiquitin ligase complex	TOPORS	IDA		Human	PMID:15247280
Biological Process	GO:0006974	DNA damage response	TOPORS	IDA		Human	PMID:15735665
Biological Process	GO:0006974	DNA damage response	Topors	IDA		Mouse	PMID:15735665
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	TOPORS	IDA		Human	PMID:20188669
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Topors	IDA		Mouse	PMID:15735665
Biological Process	GO:0051457	maintenance of protein location in nucleus	TOPORS	IDA		Human	PMID:14516784
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Topors	IGI	MGI:MGI:98834	Mouse	PMID:15735665
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	TOPORS	IDA		Human	PMID:15247280
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	TOPORS	IMP		Human	PMID:18077445
Biological Process	GO:0070936	protein K48-linked ubiquitination	TOPORS	IDA		Human	PMID:15247280
Biological Process	GO:0034504	protein localization to nucleus	TOPORS	IMP		Human	PMID:20188669
Biological Process	GO:0006513	protein monoubiquitination	TOPORS	IDA		Human	PMID:15247280
Biological Process	GO:0000209	protein polyubiquitination	TOPORS	IDA		Human	PMID:15247280
Biological Process	GO:0016925	protein sumoylation	TOPORS	IDA		Human	PMID:17803295
Biological Process	GO:0016925	protein sumoylation	TOPORS	IMP		Human	PMID:20188669
Biological Process	GO:0042127	regulation of cell population proliferation	Topors	IDA		Mouse	PMID:15735665
Biological Process	GO:0010842	retina layer formation	toporsa	IMP	ZFIN:ZDB-MRPHLNO-110331-5	Zfish	PMID:21159800
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	TOPORS	IMP		Human	PMID:19473992

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern