Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tpcn2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TPCN2
- Mouse genes Tpcn2
- Rat genes Tpcn2
- Zfish genes tpcn2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tpcn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005262	calcium channel activity	TPCN2	IDA		Human	PMID:27140606
Molecular Function	GO:0042802	identical protein binding	TPCN2	IPI	UniProtKB:Q8NHX9	Human	PMID:21903581
Molecular Function	GO:0042802	identical protein binding	TPCN2	IDA		Human	PMID:30860481
Molecular Function	GO:0097682	intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity	TPCN2	IDA		Human	PMID:23063126
Molecular Function	GO:0097682	intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity	TPCN2	IDA		Human	PMID:30860481
Molecular Function	GO:0097682	intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity	TPCN2	IDA		Human	PMID:32167471
Molecular Function	GO:0015280	ligand-gated sodium channel activity	TPCN2	IDA		Human	PMID:23063126
Molecular Function	GO:0015280	ligand-gated sodium channel activity	TPCN2	IDA		Human	PMID:30860481
Molecular Function	GO:0015280	ligand-gated sodium channel activity	TPCN2	IDA		Human	PMID:32167471
Molecular Function	GO:0015280	ligand-gated sodium channel activity	Tpcn2	IDA		Mouse	MGI:MGI:6219928\|PMID:27231233
Molecular Function	GO:0072345	NAADP-sensitive calcium-release channel activity	TPCN2	IDA		Human	PMID:19387438
Molecular Function	GO:0072345	NAADP-sensitive calcium-release channel activity	TPCN2	IDA		Human	PMID:19620632
Molecular Function	GO:0072345	NAADP-sensitive calcium-release channel activity	TPCN2	IDA		Human	PMID:20880839
Molecular Function	GO:0072345	NAADP-sensitive calcium-release channel activity	TPCN2	IDA		Human	PMID:32167471
Molecular Function	GO:0072345	NAADP-sensitive calcium-release channel activity	Tpcn2	IDA		Mouse	MGI:MGI:5285171\|PMID:19557428
Molecular Function	GO:0072345	NAADP-sensitive calcium-release channel activity	Tpcn2	IMP		Mouse	MGI:MGI:5691857\|PMID:25144390
Molecular Function	GO:0072345	NAADP-sensitive calcium-release channel activity	Tpcn2	IMP		Mouse	MGI:MGI:5285159\|PMID:20495006
Molecular Function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	TPCN2	IDA		Human	PMID:23063126
Molecular Function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	TPCN2	IDA		Human	PMID:30860481
Molecular Function	GO:0005515	protein binding	TPCN2	IPI	UniProtKB:Q9ULQ1	Human	PMID:21903581
Molecular Function	GO:0005515	protein binding	TPCN2	IPI	UniProtKB:P42345	Human	PMID:23394946
Molecular Function	GO:0005515	protein binding	TPCN2	IPI	UniProtKB:O00165	Human	PMID:24188827
Molecular Function	GO:0019901	protein kinase binding	TPCN2	IPI	UniProtKB:Q5S007	Human	PMID:22012985
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Tpcn2	IMP		Mouse	MGI:MGI:5285159\|PMID:20495006
Cellular Component	GO:0036020	endolysosome membrane	TPCN2	IDA		Human	PMID:32167471
Cellular Component	GO:0010008	endosome membrane	TPCN2	IDA		Human	PMID:19620632
Cellular Component	GO:0005765	lysosomal membrane	TPCN2	IDA		Human	PMID:19387438
Cellular Component	GO:0005765	lysosomal membrane	TPCN2	IDA		Human	PMID:19620632
Cellular Component	GO:0005765	lysosomal membrane	TPCN2	IDA		Human	PMID:20880839
Cellular Component	GO:0005765	lysosomal membrane	TPCN2	IDA		Human	PMID:23063126
Cellular Component	GO:0005765	lysosomal membrane	Tpcn2	IDA		Mouse	MGI:MGI:6716973\|PMID:32167471
Cellular Component	GO:0005765	lysosomal membrane	Tpcn2	IDA		Mouse	MGI:MGI:5285171\|PMID:19557428
Cellular Component	GO:0005764	lysosome	TPCN2	IDA		Human	PMID:22012985
Cellular Component	GO:0005764	lysosome	Tpcn2	IDA		Mouse	MGI:MGI:5285159\|PMID:20495006
Cellular Component	GO:0005764	lysosome	Tpcn2	IDA		Mouse	MGI:MGI:5691857\|PMID:25144390
Cellular Component	GO:0033162	melanosome membrane	TPCN2	IDA		Human	PMID:27140606
Cellular Component	GO:0033162	melanosome membrane	Tpcn2	IDA		Mouse	MGI:MGI:6219928\|PMID:27231233
Biological Process	GO:0019722	calcium-mediated signaling	TPCN2	IGI	UniProtKB:Q5S007	Human	PMID:25416817
Biological Process	GO:0019722	calcium-mediated signaling	Tpcn2	IMP		Mouse	MGI:MGI:5691857\|PMID:25144390
Biological Process	GO:0019722	calcium-mediated signaling	tpcn2	IMP	ZFIN:ZDB-MRPHLNO-160427-2	Zfish	PMID:28390800
Biological Process	GO:0075509	endocytosis involved in viral entry into host cell	TPCN2	IMP		Human	PMID:25722412
Biological Process	GO:0075509	endocytosis involved in viral entry into host cell	Tpcn2	IMP		Mouse	MGI:MGI:6716961\|PMID:25722412
Biological Process	GO:0090117	endosome to lysosome transport of low-density lipoprotein particle	Tpcn2	IMP		Mouse	MGI:MGI:5691857\|PMID:25144390
Biological Process	GO:0006874	intracellular calcium ion homeostasis	TPCN2	IDA		Human	PMID:19387438
Biological Process	GO:0051452	intracellular pH reduction	TPCN2	IDA		Human	PMID:27140606
Biological Process	GO:0051452	intracellular pH reduction	Tpcn2	IDA		Mouse	MGI:MGI:6219928\|PMID:27231233
Biological Process	GO:0007040	lysosome organization	TPCN2	IGI	UniProtKB:Q8NHX9	Human	PMID:25416817
Biological Process	GO:0048086	negative regulation of developmental pigmentation	TPCN2	IDA		Human	PMID:27140606
Biological Process	GO:0048086	negative regulation of developmental pigmentation	Tpcn2	IDA		Mouse	MGI:MGI:6219928\|PMID:27231233
Biological Process	GO:0019065	receptor-mediated endocytosis of virus by host cell	TPCN2	IDA		Human	PMID:32221306
Biological Process	GO:0010506	regulation of autophagy	TPCN2	IGI	UniProtKB:Q5S007	Human	PMID:22012985
Biological Process	GO:0017157	regulation of exocytosis	Tpcn2	IMP		Mouse	MGI:MGI:6716973\|PMID:32167471
Biological Process	GO:2000290	regulation of myotome development	tpcn2	IMP	ZFIN:ZDB-MRPHLNO-170630-2	Zfish	PMID:28390800
Biological Process	GO:2000290	regulation of myotome development	tpcn2	IMP	ZFIN:ZDB-MRPHLNO-160427-2	Zfish	PMID:28390800
Biological Process	GO:2000290	regulation of myotome development	tpcn2	IMP	ZFIN:ZDB-GENO-170926-4	Zfish	PMID:28390800
Biological Process	GO:2000290	regulation of myotome development	tpcn2	IMP	ZFIN:ZDB-MRPHLNO-160427-2,ZFIN:ZDB-MRPHLNO-170630-2	Zfish	PMID:28390800
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Tpcn2	IMP		Mouse	MGI:MGI:5285159\|PMID:20495006
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Tpcn2	IMP		Mouse	MGI:MGI:5691857\|PMID:25144390
Biological Process	GO:0033280	response to vitamin D	Tpcn2	IEP		Rat	PMID:20197420\|RGD:9585651
Biological Process	GO:0014866	skeletal myofibril assembly	tpcn2	IMP	ZFIN:ZDB-MRPHLNO-170630-2	Zfish	PMID:28390800
Biological Process	GO:0014866	skeletal myofibril assembly	tpcn2	IMP	ZFIN:ZDB-GENO-170926-4	Zfish	PMID:28390800
Biological Process	GO:0014866	skeletal myofibril assembly	tpcn2	IMP	ZFIN:ZDB-MRPHLNO-160427-2,ZFIN:ZDB-MRPHLNO-170630-2	Zfish	PMID:28390800
Biological Process	GO:0014866	skeletal myofibril assembly	tpcn2	IMP	ZFIN:ZDB-MRPHLNO-160427-2	Zfish	PMID:28390800
Biological Process	GO:0006939	smooth muscle contraction	Tpcn2	IMP		Mouse	MGI:MGI:4838733\|PMID:20547763
Biological Process	GO:0035725	sodium ion transmembrane transport	TPCN2	IDA		Human	PMID:30860481

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.