Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TPH1
  • Mouse genes Tph1
  • Rat genes Tph1
  • Zfish genes tph1a,tph1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tph1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TPH1	IPI	UniProtKB:O43586	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TPH1	IPI	UniProtKB:Q9H8Y8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TPH1	IPI	UniProtKB:O95789-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPH1	IPI	UniProtKB:Q14457	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPH1	IPI	UniProtKB:Q96IK1-2	Human	PMID:32814053
Molecular Function	GO:0004510	tryptophan 5-monooxygenase activity	Tph1	IDA		Mouse	PMID:2110547
Molecular Function	GO:0004510	tryptophan 5-monooxygenase activity	Tph1	IDA		Rat	PMID:12354109|RGD:724750
Cellular Component	GO:0005737	cytoplasm	Tph1	IDA		Mouse	PMID:23500099
Cellular Component	GO:0043005	neuron projection	Tph1	IDA		Rat	PMID:14744469|RGD:1580443
Biological Process	GO:0046849	bone remodeling	Tph1	IGI	MGI:MGI:1278315	Mouse	PMID:19041748
Biological Process	GO:0046849	bone remodeling	Tph1	IGI	MGI:MGI:96274	Mouse	PMID:19041748
Biological Process	GO:0007623	circadian rhythm	Tph1	IEP		Rat	PMID:18705647|RGD:5686363
Biological Process	GO:0060749	mammary gland alveolus development	Tph1	IMP	MGI:MGI:2450301	Mouse	PMID:14960274
Biological Process	GO:0030279	negative regulation of ossification	Tph1	IMP		Rat	PMID:20139991|RGD:5686362
Biological Process	GO:0002576	platelet degranulation	Tph1	IMP		Mouse	MGI:MGI:2683993|PMID:14697203
Biological Process	GO:0045600	positive regulation of fat cell differentiation	Tph1	IMP		Mouse	PMID:20719859
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	tph1a	IGI	ZFIN:ZDB-MRPHLNO-170908-2	Zfish	PMID:27424782
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	tph1a	IGI	ZFIN:ZDB-GENE-030805-6	Zfish	PMID:27424782
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	tph1a	IGI	ZFIN:ZDB-GENE-030805-6,ZFIN:ZDB-GENE-040624-4	Zfish	PMID:27424782
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	tph1b	IMP	ZFIN:ZDB-MRPHLNO-170908-3	Zfish	PMID:27424782
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	tph1b	IGI	ZFIN:ZDB-GENE-030317-1	Zfish	PMID:27424782
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	tph1b	IGI	ZFIN:ZDB-GENE-030317-1,ZFIN:ZDB-GENE-040624-4	Zfish	PMID:27424782
Biological Process	GO:1900046	regulation of hemostasis	Tph1	IMP		Mouse	MGI:MGI:2683993|PMID:14697203
Biological Process	GO:0001666	response to hypoxia	tph1a	IMP	ZFIN:ZDB-GENO-220610-1	Zfish	PMID:33271304
Biological Process	GO:0001666	response to hypoxia	tph1b	IMP	ZFIN:ZDB-GENO-220610-3	Zfish	PMID:33271304
Biological Process	GO:0001666	response to hypoxia	tph1a	IMP	ZFIN:ZDB-GENO-220610-3	Zfish	PMID:33271304
Biological Process	GO:0001666	response to hypoxia	tph1b	IMP	ZFIN:ZDB-GENO-220610-4	Zfish	PMID:33271304
Biological Process	GO:0001666	response to hypoxia	tph1b	IMP	ZFIN:ZDB-GENO-201015-6	Zfish	PMID:33271304
Biological Process	GO:0001666	response to hypoxia	tph1a	IMP	ZFIN:ZDB-GENO-220610-2	Zfish	PMID:33271304
Biological Process	GO:0001666	response to hypoxia	tph1a	IMP	ZFIN:ZDB-GENO-220610-4	Zfish	PMID:33271304
Biological Process	GO:0035902	response to immobilization stress	Tph1	IEP		Rat	PMID:14744469|RGD:1580443
Biological Process	GO:0042427	serotonin biosynthetic process	Tph1	IMP		Mouse	MGI:MGI:2683993|PMID:14697203

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern