Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TPM1
  • Mouse genes Tpm1
  • Rat genes Tpm1
  • Zfish genes tpm1,tpma
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tpm1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Tpm1	IMP		Rat	PMID:14640678|RGD:1580445
Molecular Function	GO:0003779	actin binding	Tpm1	IDA		Rat	PMID:19041430|RGD:7242195
Molecular Function	GO:0051015	actin filament binding	Tpm1	IDA		Mouse	PMID:16765662
Molecular Function	GO:0051015	actin filament binding	Tpm1	IMP		Rat	PMID:11329279|RGD:1600520
Molecular Function	GO:0051015	actin filament binding	Tpm1	IDA		Rat	PMID:22812662|RGD:12910998
Molecular Function	GO:0051015	actin filament binding	Tpm1	IDA		Rat	PMID:7568216|RGD:12911000
Molecular Function	GO:0008092	cytoskeletal protein binding	TPM1	IPI	UniProtKB:O76041	Human	PMID:17987659
Molecular Function	GO:0097718	disordered domain specific binding	Tpm1	IPI	UniProtKB:Q9DEA6	Rat	PMID:15475586|RGD:12793040
Molecular Function	GO:0042802	identical protein binding	Tpm1	IPI	RGD:3898	Rat	PMID:16420482|RGD:1580448
Molecular Function	GO:0042802	identical protein binding	Tpm1	IDA		Rat	PMID:22812662|RGD:12910998
Molecular Function	GO:0042802	identical protein binding	Tpm1	IDA		Rat	PMID:7568216|RGD:12911000
Molecular Function	GO:0005515	protein binding	TPM1	IPI	UniProtKB:Q9BQD3	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	TPM1	IPI	UniProtKB:P13805	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	TPM1	IPI	UniProtKB:P13805	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TPM1	IPI	UniProtKB:Q08379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TPM1	IPI	UniProtKB:Q8N0S2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TPM1	IPI	UniProtKB:Q8TAB5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TPM1	IPI	UniProtKB:Q8TC20	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TPM1	IPI	UniProtKB:Q9BQD3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TPM1	IPI	UniProtKB:Q9Y6D9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TPM1	IPI	UniProtKB:Q9Y6D9	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	Tpm1	IPI	UniProtKB:P68135	Mouse	MGI:MGI:5917610|PMID:25470062
Molecular Function	GO:0005515	protein binding	Tpm1	IPI	UniProtKB:Q9DEA6	Rat	PMID:15779917|RGD:1600523
Molecular Function	GO:0046982	protein heterodimerization activity	Tpm1	IDA		Rat	PMID:22812662|RGD:12910998
Molecular Function	GO:0046982	protein heterodimerization activity	Tpm1	IDA		Rat	PMID:7568216|RGD:12911000
Molecular Function	GO:0042803	protein homodimerization activity	Tpm1	IDA		Rat	PMID:22812662|RGD:12910998
Molecular Function	GO:0042803	protein homodimerization activity	Tpm1	IDA		Rat	PMID:7568216|RGD:12911000
Cellular Component	GO:0015629	actin cytoskeleton	TPM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0015629	actin cytoskeleton	Tpm1	IDA		Rat	PMID:7568216|RGD:12911000
Cellular Component	GO:0032059	bleb	TPM1	IMP		Human	PMID:12686598
Cellular Component	GO:0005737	cytoplasm	Tpm1	IDA		Mouse	PMID:16765662
Cellular Component	GO:0005829	cytosol	TPM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030016	myofibril	Tpm1	IDA		Mouse	PMID:11356630
Cellular Component	GO:0030016	myofibril	Tpm1	IDA		Mouse	PMID:9440710
Cellular Component	GO:0032991	protein-containing complex	Tpm1	IDA		Rat	PMID:15823548|RGD:1600561
Cellular Component	GO:0032587	ruffle membrane	TPM1	IDA		Human	PMID:12686598
Cellular Component	GO:0001725	stress fiber	TPM1	IDA		Human	PMID:12686598
Biological Process	GO:0051693	actin filament capping	Tpm1	IDA		Rat	PMID:15779917|RGD:1600523
Biological Process	GO:0060048	cardiac muscle contraction	TPM1	IMP		Human	PMID:11136687
Biological Process	GO:0060048	cardiac muscle contraction	Tpm1	IMP		Mouse	MGI:MGI:3802907|PMID:17556658
Biological Process	GO:0060048	cardiac muscle contraction	Tpm1	IDA		Rat	PMID:14551059|RGD:1600569
Biological Process	GO:0034614	cellular response to reactive oxygen species	TPM1	IEP		Human	PMID:12686598
Biological Process	GO:0009790	embryo development	Tpm1	IMP	MGI:MGI:2385810	Mouse	PMID:9400381
Biological Process	GO:0001701	in utero embryonic development	Tpm1	IMP	MGI:MGI:2387893	Mouse	PMID:9440710
Biological Process	GO:0030049	muscle filament sliding	Tpm1	IDA		Rat	PMID:11136687|RGD:1556479
Biological Process	GO:0061515	myeloid cell development	tpma	IMP	ZFIN:ZDB-MRPHLNO-160526-14	Zfish	PMID:22139419
Biological Process	GO:0030336	negative regulation of cell migration	Tpm1	IGI		Rat	PMID:15897890|RGD:8656006
Biological Process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	TPM1	IMP		Human	PMID:21817107
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	TPM1	IMP		Human	PMID:21817107
Biological Process	GO:0032781	positive regulation of ATP-dependent activity	Tpm1	IDA		Rat	PMID:11136687|RGD:1556479
Biological Process	GO:0032781	positive regulation of ATP-dependent activity	Tpm1	IMP		Rat	PMID:11329279|RGD:1600520
Biological Process	GO:0045785	positive regulation of cell adhesion	Tpm1	IGI		Rat	PMID:17721995|RGD:8656010
Biological Process	GO:0003065	positive regulation of heart rate by epinephrine	Tpm1	IMP		Mouse	MGI:MGI:3802907|PMID:17556658
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Tpm1	IGI		Rat	PMID:15897890|RGD:8656006
Biological Process	GO:0043462	regulation of ATP-dependent activity	Tpm1	IDA		Rat	PMID:19041430|RGD:7242195
Biological Process	GO:0008360	regulation of cell shape	TPM1	IMP		Human	PMID:21817107
Biological Process	GO:0031529	ruffle organization	Tpm1	IGI		Rat	PMID:15897890|RGD:8656006
Biological Process	GO:0045214	sarcomere organization	TPM1	IMP		Human	PMID:11273725
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	TPM1	IMP		Human	PMID:11136687
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	Tpm1	IMP		Mouse	MGI:MGI:3802907|PMID:17556658
Biological Process	GO:0042060	wound healing	Tpm1	IGI		Rat	PMID:17721995|RGD:8656010

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern