Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TPP1
  • Mouse genes Tpp1
  • Rat genes Tpp1
  • Zfish genes tpp1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tpp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	TPP1	IMP		Human	PMID:10679303
Molecular Function	GO:0004175	endopeptidase activity	TPP1	IDA		Human	PMID:10965052
Molecular Function	GO:0004175	endopeptidase activity	Tpp1	IDA		Rat	PMID:10679303|RGD:1581099
Molecular Function	GO:0035727	lysophosphatidic acid binding	TPP1	IDA		Human	PMID:18317235
Molecular Function	GO:0008233	peptidase activity	TPP1	IMP		Human	PMID:9295267
Molecular Function	GO:0042277	peptide binding	Tpp1	IDA		Rat	PMID:10679303|RGD:1581099
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:O75503	Human	PMID:12134079
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:P50897	Human	PMID:17237713
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:Q13286	Human	PMID:17237713
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:Q3UMW8	Human	PMID:19941651
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:Q92900	Human	PMID:21829167
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:E5LBV4	Human	PMID:25544563
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:O00308	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:P45974-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:Q53EZ4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:Q6P3S6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:Q8NAP3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:Q96D59	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:Q96FW1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:Q9BUZ4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:Q9NSE2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:Q9NWX5-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPP1	IPI	UniProtKB:Q9UKA2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Tpp1	IPI	UniProtKB:Q3UMW8	Mouse	MGI:MGI:5795821|PMID:19941651
Molecular Function	GO:0005515	protein binding	Tpp1	IPI	UniProtKB:Q91WC1	Mouse	MGI:MGI:3692019|PMID:17053789
Molecular Function	GO:0008236	serine-type peptidase activity	TPP1	IMP		Human	PMID:11054422
Molecular Function	GO:0120146	sulfatide binding	TPP1	IDA		Human	PMID:18317235
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	TPP1	IMP		Human	PMID:10617131
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	TPP1	IMP		Human	PMID:10679303
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	TPP1	IDA		Human	PMID:10965052
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	TPP1	IDA		Human	PMID:11054422
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	TPP1	IDA		Human	PMID:12134079
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	Tpp1	IDA		Mouse	PMID:28728022
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	Tpp1	IDA		Rat	PMID:10679303|RGD:1581099
Cellular Component	GO:0070062	extracellular exosome	TPP1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	TPP1	HDA		Human	PMID:23533145
Cellular Component	GO:0005794	Golgi apparatus	TPP1	IDA		Human	PMID:17237713
Cellular Component	GO:0005764	lysosome	TPP1	IDA		Human	PMID:15317752
Cellular Component	GO:0005764	lysosome	TPP1	IDA		Human	PMID:17237713
Cellular Component	GO:0005764	lysosome	TPP1	IDA		Human	PMID:19941651
Cellular Component	GO:0005764	lysosome	TPP1	IMP		Human	PMID:9295267
Cellular Component	GO:0005764	lysosome	Tpp1	IDA		Mouse	MGI:MGI:5795821|PMID:19941651
Cellular Component	GO:0045121	membrane raft	TPP1	IDA		Human	PMID:17237713
Cellular Component	GO:0005739	mitochondrion	Tpp1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0055037	recycling endosome	TPP1	IDA		Human	PMID:17237713
Biological Process	GO:0045453	bone resorption	TPP1	IMP		Human	PMID:8215436
Biological Process	GO:0007417	central nervous system development	tpp1	IMP	ZFIN:ZDB-MRPHLNO-130718-1	Zfish	PMID:23587805
Biological Process	GO:0007417	central nervous system development	tpp1	IMP	ZFIN:ZDB-MRPHLNO-130718-2	Zfish	PMID:23587805
Biological Process	GO:0007417	central nervous system development	tpp1	IMP	ZFIN:ZDB-GENO-100507-6	Zfish	PMID:23587805
Biological Process	GO:0030855	epithelial cell differentiation	TPP1	IEP		Human	PMID:21492153
Biological Process	GO:0007626	locomotory behavior	tpp1	IMP	ZFIN:ZDB-GENO-100507-6	Zfish	PMID:23587805
Biological Process	GO:1905146	lysosomal protein catabolic process	Tpp1	IMP		Mouse	PMID:28728022
Biological Process	GO:0007040	lysosome organization	Tpp1	IMP	MGI:MGI:3521972	Mouse	PMID:15483130
Biological Process	GO:0007399	nervous system development	TPP1	IMP		Human	PMID:9295267
Biological Process	GO:0022008	neurogenesis	tpp1	IMP	ZFIN:ZDB-GENO-100507-6	Zfish	PMID:23587805
Biological Process	GO:0022008	neurogenesis	tpp1	IMP	ZFIN:ZDB-MRPHLNO-130718-1	Zfish	PMID:23587805
Biological Process	GO:0022008	neurogenesis	tpp1	IMP	ZFIN:ZDB-MRPHLNO-130718-2	Zfish	PMID:23587805
Biological Process	GO:0050885	neuromuscular process controlling balance	Tpp1	IMP	MGI:MGI:3521972	Mouse	PMID:15483130
Biological Process	GO:0043171	peptide catabolic process	TPP1	IMP		Human	PMID:15158442
Biological Process	GO:0043171	peptide catabolic process	TPP1	IMP		Human	PMID:9989590
Biological Process	GO:0030163	protein catabolic process	Tpp1	IDA		Rat	PMID:10679303|RGD:1581099
Biological Process	GO:0070198	protein localization to chromosome, telomeric region	TPP1	IMP		Human	PMID:20404094
Biological Process	GO:0006508	proteolysis	TPP1	IMP		Human	PMID:10965052
Biological Process	GO:0006508	proteolysis	TPP1	IMP		Human	PMID:9295267

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern