Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TPR
  • Mouse genes Tpr
  • Rat genes Tpr
  • Zfish genes tpra,tprb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tpr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	TPR	IDA		Human	PMID:17897941
Molecular Function	GO:0070840	dynein complex binding	TPR	IDA		Human	PMID:20133940
Molecular Function	GO:0031072	heat shock protein binding	TPR	IDA		Human	PMID:17897941
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	TPR	IDA		Human	PMID:18794356
Molecular Function	GO:0003729	mRNA binding	TPR	IDA		Human	PMID:17897941
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:P49790	Human	PMID:12802065
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:Q9UKX7	Human	PMID:12802065
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:P42858	Human	PMID:15654337
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:Q00613	Human	PMID:17897941
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:P27361	Human	PMID:18794356
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:P28482	Human	PMID:18794356
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:Q13257	Human	PMID:18981471
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:Q9Y6D9	Human	PMID:18981471
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:P33981	Human	PMID:19273613
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:Q13257	Human	PMID:19273613
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:Q9Y6D9	Human	PMID:19273613
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:P49790	Human	PMID:20133940
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:P63167	Human	PMID:20133940
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:Q13257	Human	PMID:20133940
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:Q14203	Human	PMID:20133940
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:P28482	Human	PMID:22253824
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:Q9Y6D9	Human	PMID:24581499
Molecular Function	GO:0005515	protein binding	TPR	IPI	UniProtKB:Q13330	Human	PMID:24970816
Molecular Function	GO:0005515	protein binding	Tpr	IPI	UniProtKB:P0DOV2	Mouse	MGI:MGI:5487541|PMID:12513910
Molecular Function	GO:0005515	protein binding	Tpr	IPI	UniProtKB:Q9H2G2	Mouse	MGI:MGI:5787763|PMID:26094769
Molecular Function	GO:0042803	protein homodimerization activity	TPR	IDA		Human	PMID:11514627
Molecular Function	GO:0042803	protein homodimerization activity	TPR	IDA		Human	PMID:12802065
Molecular Function	GO:0003723	RNA binding	TPR	HDA		Human	PMID:22658674
Molecular Function	GO:0017056	structural constituent of nuclear pore	TPR	IDA		Human	PMID:22253824
Molecular Function	GO:0015631	tubulin binding	TPR	IDA		Human	PMID:20133940
Cellular Component	GO:0005737	cytoplasm	TPR	IDA		Human	PMID:11952838
Cellular Component	GO:0005737	cytoplasm	TPR	IDA		Human	PMID:12802065
Cellular Component	GO:0005868	cytoplasmic dynein complex	TPR	IDA		Human	PMID:20133940
Cellular Component	GO:0019898	extrinsic component of membrane	TPR	IDA		Human	PMID:12802065
Cellular Component	GO:0000776	kinetochore	TPR	IDA		Human	PMID:20133940
Cellular Component	GO:0072686	mitotic spindle	TPR	IDA		Human	PMID:20133940
Cellular Component	GO:0005635	nuclear envelope	TPR	IDA		Human	PMID:17098863
Cellular Component	GO:0005635	nuclear envelope	TPR	IDA		Human	PMID:24315095
Cellular Component	GO:0005635	nuclear envelope	TPR	IDA		Human	PMID:24970816
Cellular Component	GO:0005635	nuclear envelope	Tpr	IDA		Mouse	MGI:MGI:5487541|PMID:12513910
Cellular Component	GO:0005635	nuclear envelope	Tpr	IDA		Mouse	PMID:12424524
Cellular Component	GO:0042405	nuclear inclusion body	TPR	IDA		Human	PMID:11514627
Cellular Component	GO:0042405	nuclear inclusion body	TPR	IDA		Human	PMID:11839768
Cellular Component	GO:0042405	nuclear inclusion body	Tpr	IDA		Mouse	MGI:MGI:5487541|PMID:12513910
Cellular Component	GO:0042405	nuclear inclusion body	Tpr	IDA		Rat	PMID:11839768|RGD:8553300
Cellular Component	GO:0031965	nuclear membrane	TPR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031965	nuclear membrane	TPR	IDA		Human	PMID:11514627
Cellular Component	GO:0031965	nuclear membrane	TPR	IDA		Human	PMID:11839768
Cellular Component	GO:0031965	nuclear membrane	TPR	IDA		Human	PMID:11952838
Cellular Component	GO:0031965	nuclear membrane	TPR	IDA		Human	PMID:12802065
Cellular Component	GO:0031965	nuclear membrane	TPR	IDA		Human	PMID:15229283
Cellular Component	GO:0031965	nuclear membrane	TPR	IDA		Human	PMID:18794356
Cellular Component	GO:0031965	nuclear membrane	TPR	IDA		Human	PMID:20407419
Cellular Component	GO:0031965	nuclear membrane	TPR	IDA		Human	PMID:22253824
Cellular Component	GO:0031965	nuclear membrane	TPR	IDA		Human	PMID:9024684
Cellular Component	GO:0031965	nuclear membrane	TPR	IDA		Human	PMID:9828100
Cellular Component	GO:0031965	nuclear membrane	TPR	IDA		Human	PMID:9864356
Cellular Component	GO:0031965	nuclear membrane	Tpr	IDA		Rat	PMID:11839768|RGD:8553300
Cellular Component	GO:0034399	nuclear periphery	TPR	IDA		Human	PMID:11514627
Cellular Component	GO:0034399	nuclear periphery	TPR	IDA		Human	PMID:11839768
Cellular Component	GO:0034399	nuclear periphery	TPR	IDA		Human	PMID:11952838
Cellular Component	GO:0034399	nuclear periphery	TPR	IDA		Human	PMID:15229283
Cellular Component	GO:0034399	nuclear periphery	TPR	IDA		Human	PMID:22401879
Cellular Component	GO:0034399	nuclear periphery	TPR	IDA		Human	PMID:9024684
Cellular Component	GO:0034399	nuclear periphery	Tpr	IDA		Mouse	MGI:MGI:5487504|PMID:22401879
Cellular Component	GO:0034399	nuclear periphery	Tpr	IDA		Rat	PMID:11839768|RGD:8553300
Cellular Component	GO:0005643	nuclear pore	TPR	IDA		Human	PMID:11514627
Cellular Component	GO:0005643	nuclear pore	TPR	IDA		Human	PMID:12802065
Cellular Component	GO:0005643	nuclear pore	TPR	IDA		Human	PMID:9828100
Cellular Component	GO:0005643	nuclear pore	TPR	IDA		Human	PMID:9864356
Cellular Component	GO:0005643	nuclear pore	Tpr	IDA		Mouse	MGI:MGI:5487541|PMID:12513910
Cellular Component	GO:0044615	nuclear pore nuclear basket	TPR	IDA		Human	PMID:11839768
Cellular Component	GO:0044615	nuclear pore nuclear basket	TPR	IDA		Human	PMID:15229283
Cellular Component	GO:0044615	nuclear pore nuclear basket	TPR	IDA		Human	PMID:18981471
Cellular Component	GO:0044615	nuclear pore nuclear basket	TPR	IDA		Human	PMID:9024684
Cellular Component	GO:0044615	nuclear pore nuclear basket	Tpr	IDA		Rat	PMID:11839768|RGD:8553300
Cellular Component	GO:0005634	nucleus	TPR	IDA		Human	PMID:15654337
Biological Process	GO:0034605	cellular response to heat	TPR	IDA		Human	PMID:17897941
Biological Process	GO:0035457	cellular response to interferon-alpha	Tpr	IDA		Mouse	MGI:MGI:5487541|PMID:12513910
Biological Process	GO:0007094	mitotic spindle assembly checkpoint signaling	TPR	IMP		Human	PMID:20133940
Biological Process	GO:0031990	mRNA export from nucleus in response to heat stress	TPR	IDA		Human	PMID:17897941
Biological Process	GO:0046832	negative regulation of RNA export from nucleus	TPR	IMP		Human	PMID:21613532
Biological Process	GO:0046832	negative regulation of RNA export from nucleus	TPR	IDA		Human	PMID:22253824
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	TPR	IMP		Human	PMID:21613532
Biological Process	GO:0045947	negative regulation of translational initiation	TPR	IMP		Human	PMID:21613532
Biological Process	GO:0006999	nuclear pore organization	TPR	IMP		Human	PMID:15229283
Biological Process	GO:0031453	positive regulation of heterochromatin formation	TPR	IMP		Human	PMID:20407419
Biological Process	GO:0090316	positive regulation of intracellular protein transport	TPR	IMP		Human	PMID:19273613
Biological Process	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	TPR	IMP		Human	PMID:18981471
Biological Process	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	TPR	IMP		Human	PMID:19273613
Biological Process	GO:0046827	positive regulation of protein export from nucleus	Tpr	IMP		Rat	PMID:11839768|RGD:8553300
Biological Process	GO:0042307	positive regulation of protein import into nucleus	TPR	IMP		Human	PMID:18794356
Biological Process	GO:0006611	protein export from nucleus	Tpr	IMP		Rat	PMID:11839768|RGD:8553300
Biological Process	GO:0006606	protein import into nucleus	TPR	IMP		Human	PMID:18794356
Biological Process	GO:0010965	regulation of mitotic sister chromatid separation	TPR	IMP		Human	PMID:20133940
Biological Process	GO:1901673	regulation of mitotic spindle assembly	TPR	IMP		Human	PMID:19273613
Biological Process	GO:0032880	regulation of protein localization	TPR	IMP		Human	PMID:18981471
Biological Process	GO:0070849	response to epidermal growth factor	TPR	IDA		Human	PMID:18794356
Biological Process	GO:0006405	RNA export from nucleus	TPR	IMP		Human	PMID:11952838
Biological Process	GO:0006404	RNA import into nucleus	TPR	IDA		Human	PMID:9864356

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern