Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TPX2
  • Mouse genes Tpx2
  • Rat genes Tpx2
  • Zfish genes tpx2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tpx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0061676	importin-alpha family protein binding	TPX2	IDA		Human	PMID:26165940
Molecular Function	GO:0061676	importin-alpha family protein binding	Tpx2	IDA		Mouse	MGI:MGI:5689196|PMID:26165940
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:O14965	Human	PMID:14580337
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:P27986	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:O14965	Human	PMID:19357306
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:O14965	Human	PMID:20360068
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:Q00839	Human	PMID:21242313
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:O14965	Human	PMID:22110403
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:O75330	Human	PMID:22110403
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:Q08379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:Q00839	Human	PMID:25986610
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:O14965	Human	PMID:27837025
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:O14965	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:Q08379	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:P12830	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:P27797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:P36957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:Q15078	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:Q8TDX7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TPX2	IPI	UniProtKB:O00629	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Tpx2	IPI	UniProtKB:Q9Z0F3	Mouse	MGI:MGI:6867120|PMID:27753540
Molecular Function	GO:0005515	protein binding	Tpx2	IPI	PR:P97477	Mouse	PMID:19668197
Molecular Function	GO:0019901	protein kinase binding	TPX2	IPI	UniProtKB:O14965	Human	PMID:14580337
Molecular Function	GO:0019901	protein kinase binding	TPX2	IPI	UniProtKB:O14965	Human	PMID:18662907
Molecular Function	GO:0019901	protein kinase binding	TPX2	IPI	UniProtKB:O14965	Human	PMID:19801554
Molecular Function	GO:0019901	protein kinase binding	Tpx2	IPI	UniProtKB:O14965	Mouse	MGI:MGI:4457240|PMID:18663142
Cellular Component	GO:0043203	axon hillock	Tpx2	IDA		Mouse	PMID:19668197
Cellular Component	GO:0045171	intercellular bridge	TPX2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0015630	microtubule cytoskeleton	TPX2	IDA		Human	GO_REF:0000054
Cellular Component	GO:0072686	mitotic spindle	TPX2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TPX2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005819	spindle	Tpx2	IDA		Mouse	MGI:MGI:4457240|PMID:18663142
Cellular Component	GO:0005819	spindle	Tpx2	IDA		Mouse	MGI:MGI:6867120|PMID:27753540
Cellular Component	GO:0000922	spindle pole	TPX2	IDA		Human	PMID:14718566
Biological Process	GO:0032147	activation of protein kinase activity	TPX2	IDA		Human	PMID:14580337
Biological Process	GO:0032147	activation of protein kinase activity	TPX2	IDA		Human	PMID:19801554
Biological Process	GO:0007020	microtubule nucleation	TPX2	IDA		Human	PMID:26414402
Biological Process	GO:0090307	mitotic spindle assembly	TPX2	IDA		Human	PMID:26165940
Biological Process	GO:0090307	mitotic spindle assembly	Tpx2	IMP		Mouse	MGI:MGI:5689196|PMID:26165940
Biological Process	GO:0007026	negative regulation of microtubule depolymerization	TPX2	IDA		Human	PMID:26414402
Biological Process	GO:0060236	regulation of mitotic spindle organization	Tpx2	IMP		Mouse	MGI:MGI:4457240|PMID:18663142

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern