Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRADD
  • Mouse genes Tradd
  • Rat genes Tradd
  • Zfish genes tradd
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tradd

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070513	death domain binding	TRADD	IPI	UniProtKB:Q13546	Human	PMID:8612133
Molecular Function	GO:0042802	identical protein binding	TRADD	IPI	UniProtKB:Q15628	Human	PMID:11684708
Molecular Function	GO:0042802	identical protein binding	TRADD	IPI	UniProtKB:Q15628	Human	PMID:30561431
Molecular Function	GO:0042802	identical protein binding	TRADD	IPI	UniProtKB:Q15628	Human	PMID:7758105
Molecular Function	GO:0019900	kinase binding	TRADD	IPI	UniProtKB:Q13546	Human	PMID:8612133
Molecular Function	GO:0060090	molecular adaptor activity	TRADD	IDA		Human	PMID:7758105
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:O95999	Human	PMID:1040062
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P42224	Human	PMID:10848577
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q12933	Human	PMID:10892748
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q13158	Human	PMID:11112409
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P25118	Human	PMID:11374864
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P02533	Human	PMID:11684708
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P05783	Human	PMID:11684708
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P19438	Human	PMID:11684708
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q12933	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P19438	Human	PMID:16611992
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P03230	Human	PMID:18198944
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P03230	Human	PMID:19379743
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P19438	Human	PMID:19524513
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P19438	Human	PMID:19641494
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P19438	Human	PMID:19781631
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:O94826	Human	PMID:20628368
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P23396	Human	PMID:22510408
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q12933	Human	PMID:23429285
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q8IU68	Human	PMID:23429285
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:B7UI21	Human	PMID:23955153
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P19438	Human	PMID:23955153
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q12933	Human	PMID:23955153
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q13158	Human	PMID:23955153
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:B7UI21	Human	PMID:24025841
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P19438	Human	PMID:24130170
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q12933	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q13158	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q12933	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q13158	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P19438	Human	PMID:7758105
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P19438	Human	PMID:8565075
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q12933	Human	PMID:8565075
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P19438	Human	PMID:8943045
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:P78560	Human	PMID:8985253
Molecular Function	GO:0005515	protein binding	TRADD	IPI	UniProtKB:Q12933	Human	PMID:9020361
Molecular Function	GO:0005515	protein binding	Tradd	IPI	UniProtKB:Q3U0V2|UniProtKB:Q61781|UniProtKB:Q9QWL7|UniProtKB:Q9Z2K1	Mouse	MGI:MGI:3624581|PMID:16702408
Molecular Function	GO:0005515	protein binding	Tradd	IPI	UniProtKB:Q61160	Mouse	MGI:MGI:6377951|PMID:30185824
Molecular Function	GO:0005515	protein binding	Tradd	IPI	UniProtKB:P01375	Mouse	MGI:MGI:5706670|PMID:26649818
Molecular Function	GO:0005515	protein binding	Tradd	IPI	UniProtKB:Q60855|UniProtKB:Q9QUK6	Mouse	MGI:MGI:3806433|PMID:18719121
Molecular Function	GO:0005515	protein binding	Tradd	IPI	PR:Q8CFV9	Mouse	PMID:19641494
Molecular Function	GO:0005515	protein binding	Tradd	IPI	RGD:1310158	Rat	PMID:12786973|RGD:2298728
Molecular Function	GO:0044877	protein-containing complex binding	Tradd	IPI	RGD:621237|RGD:1560875	Rat	PMID:12786973|RGD:2298728
Molecular Function	GO:0044877	protein-containing complex binding	Tradd	IPI	RGD:621237|RGD:1310457	Rat	PMID:15590916|RGD:1624191
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	TRADD	IPI	UniProtKB:Q13546	Human	PMID:8612133
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	Tradd	IPI	RGD:621237	Rat	PMID:20649583|RGD:5130976
Cellular Component	GO:0005737	cytoplasm	TRADD	IDA		Human	PMID:11684708
Cellular Component	GO:0005737	cytoplasm	TRADD	IDA		Human	PMID:22510408
Cellular Component	GO:0005737	cytoplasm	Tradd	IDA		Mouse	MGI:MGI:3624581|PMID:16702408
Cellular Component	GO:0045121	membrane raft	Tradd	IDA		Rat	PMID:15590916|RGD:1624191
Cellular Component	GO:0005886	plasma membrane	TRADD	IDA		Human	PMID:22510408
Cellular Component	GO:0032991	protein-containing complex	Tradd	IDA		Rat	PMID:12786973|RGD:2298728
Cellular Component	GO:0032991	protein-containing complex	Tradd	IDA		Rat	PMID:15590916|RGD:1624191
Cellular Component	GO:0043235	receptor complex	TRADD	IDA		Human	PMID:8612133
Cellular Component	GO:0002947	tumor necrosis factor receptor superfamily complex	TRADD	IDA		Human	PMID:23429285
Biological Process	GO:0071356	cellular response to tumor necrosis factor	TRADD	IMP		Human	PMID:25732226
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	TRADD	IMP		Human	PMID:16611992
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Tradd	IGI	MGI:MGI:104798	Mouse	PMID:22089168
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Tradd	IGI	MGI:MGI:108212	Mouse	PMID:22089168
Biological Process	GO:0043065	positive regulation of apoptotic process	tradd	IDA		Zfish	PMID:16888647
Biological Process	GO:0030335	positive regulation of cell migration	TRADD	IMP		Human	PMID:25732226
Biological Process	GO:0051798	positive regulation of hair follicle development	Tradd	IMP		Mouse	MGI:MGI:3624581|PMID:16702408
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TRADD	IEP		Human	PMID:12761501
Biological Process	GO:0050729	positive regulation of inflammatory response	TRADD	IMP		Human	PMID:25732226
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TRADD	IMP		Human	PMID:25732226
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	TRADD	IMP		Human	PMID:25732226
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	TRADD	IDA		Human	PMID:7758105

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern