Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TREM2
  • Mouse genes Trem2
  • Rat genes Trem2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trem2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	TREM2	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:29518356
Molecular Function	GO:0034186	apolipoprotein A-I binding	TREM2	IPI	UniProtKB:P02647	Human	PMID:27477018
Molecular Function	GO:0034185	apolipoprotein binding	TREM2	IPI	UniProtKB:P02649	Human	PMID:27477018
Molecular Function	GO:0034185	apolipoprotein binding	TREM2	IPI	UniProtKB:P02652	Human	PMID:27477018
Molecular Function	GO:0034185	apolipoprotein binding	TREM2	IPI	UniProtKB:P04114	Human	PMID:27477018
Molecular Function	GO:0034185	apolipoprotein binding	TREM2	IPI	UniProtKB:P10909	Human	PMID:27477018
Molecular Function	GO:0008035	high-density lipoprotein particle binding	TREM2	IDA		Human	PMID:27477018
Molecular Function	GO:0019209	kinase activator activity	TREM2	IMP		Human	PMID:31902528
Molecular Function	GO:0001530	lipopolysaccharide binding	Trem2	IDA		Mouse	MGI:MGI:5572888|PMID:12847223
Molecular Function	GO:0001530	lipopolysaccharide binding	Trem2	IDA		Mouse	PMID:19079182
Molecular Function	GO:0071813	lipoprotein particle binding	TREM2	IDA		Human	PMID:27477018
Molecular Function	GO:0070891	lipoteichoic acid binding	Trem2	IDA		Mouse	MGI:MGI:5572888|PMID:12847223
Molecular Function	GO:0030169	low-density lipoprotein particle binding	TREM2	IDA		Human	PMID:27477018
Molecular Function	GO:0140677	molecular function activator activity	TREM2	IDA		Human	PMID:29518356
Molecular Function	GO:0042834	peptidoglycan binding	Trem2	IDA		Mouse	MGI:MGI:5572888|PMID:12847223
Molecular Function	GO:0008429	phosphatidylethanolamine binding	TREM2	IDA		Human	PMID:31101881
Molecular Function	GO:0001786	phosphatidylserine binding	TREM2	IDA		Human	PMID:31101881
Molecular Function	GO:0001786	phosphatidylserine binding	TREM2	IDA		Human	PMID:31902528
Molecular Function	GO:0005543	phospholipid binding	TREM2	IDA		Human	PMID:27995897
Molecular Function	GO:0005515	protein binding	TREM2	IPI	UniProtKB:O43914	Human	PMID:11602640
Molecular Function	GO:0005515	protein binding	TREM2	IPI	UniProtKB:O43914	Human	PMID:28490631
Molecular Function	GO:0005515	protein binding	TREM2	IPI	UniProtKB:P49768	Human	PMID:29611543
Molecular Function	GO:0005515	protein binding	TREM2	IPI	UniProtKB:P02649	Human	PMID:30341064
Molecular Function	GO:0005515	protein binding	TREM2	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:30341064
Molecular Function	GO:0005515	protein binding	Trem2	IPI	UniProtKB:P05067:PRO_0000000092	Mouse	MGI:MGI:6355593|PMID:30341064
Molecular Function	GO:0005515	protein binding	Trem2	IPI	UniProtKB:P70206	Mouse	MGI:MGI:5319714|PMID:22522930
Molecular Function	GO:0005515	protein binding	Trem2	IPI	PR:P58281	Mouse	PMID:19079182
Molecular Function	GO:1990782	protein tyrosine kinase binding	Trem2	IPI	UniProtKB:O54885	Mouse	MGI:MGI:6150565|PMID:29518356
Molecular Function	GO:0044877	protein-containing complex binding	TREM2	IPI	ComplexPortal:CPX-1120	Human	PMID:29518356
Molecular Function	GO:0097110	scaffold protein binding	TREM2	IPI	UniProtKB:O43914	Human	PMID:11602640
Molecular Function	GO:0038023	signaling receptor activity	TREM2	IMP		Human	PMID:32514138
Molecular Function	GO:0038023	signaling receptor activity	Trem2	IMP		Mouse	MGI:MGI:6150565|PMID:29518356
Molecular Function	GO:0120146	sulfatide binding	TREM2	IDA		Human	PMID:31902528
Molecular Function	GO:0004888	transmembrane signaling receptor activity	TREM2	IDA		Human	PMID:29518356
Molecular Function	GO:0034189	very-low-density lipoprotein particle binding	TREM2	IDA		Human	PMID:27477018
Cellular Component	GO:0009986	cell surface	TREM2	IDA		Human	PMID:24078628
Cellular Component	GO:0016020	membrane	TREM2	IDA		Human	PMID:11602640
Cellular Component	GO:0005886	plasma membrane	TREM2	IMP		Human	PMID:24990881
Cellular Component	GO:0005886	plasma membrane	TREM2	IMP		Human	PMID:27589997
Cellular Component	GO:0005886	plasma membrane	TREM2	IDA		Human	PMID:27995897
Cellular Component	GO:0005886	plasma membrane	TREM2	IMP		Human	PMID:28855300
Cellular Component	GO:0005886	plasma membrane	TREM2	IMP		Human	PMID:28855301
Cellular Component	GO:0005886	plasma membrane	Trem2	IMP		Mouse	MGI:MGI:5606096|PMID:24990881
Cellular Component	GO:0005886	plasma membrane	Trem2	IDA		Mouse	MGI:MGI:6294200|PMID:28855301
Cellular Component	GO:0005886	plasma membrane	Trem2	IMP		Mouse	MGI:MGI:6193432|PMID:29859094
Cellular Component	GO:0044853	plasma membrane raft	TREM2	IDA		Human	PMID:31413141
Biological Process	GO:0097242	amyloid-beta clearance	Trem2	IMP		Mouse	MGI:MGI:6193432|PMID:29859094
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	TREM2	IMP		Human	PMID:33097708
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	Trem2	IMP		Mouse	MGI:MGI:6313424|PMID:30617257
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	Trem2	IMP		Mouse	MGI:MGI:6393391|PMID:31980586
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	Trem2	IMP		Mouse	MGI:MGI:6695864|PMID:31134514
Biological Process	GO:0043277	apoptotic cell clearance	Trem2	IMP		Mouse	MGI:MGI:3531054|PMID:15728241
Biological Process	GO:0048143	astrocyte activation	Trem2	IGI	UniProtKB:P10636	Mouse	MGI:MGI:6095556|PMID:29073081
Biological Process	GO:1904646	cellular response to amyloid-beta	Trem2	IGI	ComplexPortal:CPX-1120	Mouse	MGI:MGI:6150565|PMID:29518356
Biological Process	GO:0071333	cellular response to glucose stimulus	Trem2	IMP		Rat	PMID:31900229|RGD:126781734
Biological Process	GO:0071456	cellular response to hypoxia	Trem2	IMP		Rat	PMID:31900229|RGD:126781734
Biological Process	GO:0071396	cellular response to lipid	TREM2	IMP		Human	PMID:32514138
Biological Process	GO:0071223	cellular response to lipoteichoic acid	Trem2	IDA		Mouse	MGI:MGI:5572888|PMID:12847223
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	TREM2	IDA		Human	PMID:31902528
Biological Process	GO:0071224	cellular response to peptidoglycan	Trem2	IDA		Mouse	MGI:MGI:5572888|PMID:12847223
Biological Process	GO:0150062	complement-mediated synapse pruning	Trem2	IMP		Mouse	MGI:MGI:6275756|PMID:30548312
Biological Process	GO:0038160	CXCL12-activated CXCR4 signaling pathway	TREM2	IMP		Human	PMID:33097708
Biological Process	GO:0042742	defense response to bacterium	Trem2	IMP		Mouse	MGI:MGI:6201658|PMID:30232263
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Trem2	IMP		Mouse	MGI:MGI:6391726|PMID:29887864
Biological Process	GO:0097028	dendritic cell differentiation	TREM2	IDA		Human	PMID:11602640
Biological Process	GO:0097062	dendritic spine maintenance	Trem2	IMP		Mouse	MGI:MGI:6393391|PMID:31980586
Biological Process	GO:0032497	detection of lipopolysaccharide	Trem2	IDA		Mouse	MGI:MGI:5572888|PMID:12847223
Biological Process	GO:0070392	detection of lipoteichoic acid	Trem2	IDA		Mouse	MGI:MGI:5572888|PMID:12847223
Biological Process	GO:0032499	detection of peptidoglycan	Trem2	IDA		Mouse	MGI:MGI:5572888|PMID:12847223
Biological Process	GO:1905805	excitatory synapse pruning	Trem2	IMP		Mouse	MGI:MGI:6284411|PMID:29752066
Biological Process	GO:0098657	import into cell	Trem2	IGI	UniProtKB:P10636	Mouse	MGI:MGI:6095556|PMID:29073081
Biological Process	GO:0055088	lipid homeostasis	Trem2	IMP		Mouse	MGI:MGI:6342648|PMID:31257031
Biological Process	GO:0007613	memory	TREM2	IMP		Human	PMID:29518357
Biological Process	GO:0007613	memory	TREM2	IDA		Human	PMID:31462511
Biological Process	GO:0001774	microglial cell activation	Trem2	IMP		Mouse	MGI:MGI:5906931|PMID:28802038
Biological Process	GO:0001774	microglial cell activation	Trem2	IMP		Mouse	MGI:MGI:6294162|PMID:28592261
Biological Process	GO:0001774	microglial cell activation	Trem2	IMP		Mouse	MGI:MGI:6695683|PMID:29663649
Biological Process	GO:0001774	microglial cell activation	Trem2	IGI	UniProtKB:P10636	Mouse	MGI:MGI:6095556|PMID:29073081
Biological Process	GO:0001774	microglial cell activation	Trem2	IGI	ComplexPortal:CPX-1120	Mouse	MGI:MGI:6150565|PMID:29518356
Biological Process	GO:0002282	microglial cell activation involved in immune response	Trem2	IMP		Mouse	MGI:MGI:6201658|PMID:30232263
Biological Process	GO:0061518	microglial cell proliferation	Trem2	IMP		Mouse	MGI:MGI:6304666|PMID:25631124
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	Trem2	IMP		Mouse	MGI:MGI:6313424|PMID:30617257
Biological Process	GO:0043066	negative regulation of apoptotic process	Trem2	IMP		Mouse	MGI:MGI:6294162|PMID:28592261
Biological Process	GO:0061889	negative regulation of astrocyte activation	Trem2	IDA		Mouse	MGI:MGI:6152919|PMID:29407460
Biological Process	GO:1904093	negative regulation of autophagic cell death	Trem2	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:5906931|PMID:28802038
Biological Process	GO:0010507	negative regulation of autophagy	Trem2	IMP		Mouse	MGI:MGI:5906931|PMID:28802038
Biological Process	GO:0010507	negative regulation of autophagy	Trem2	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:5906931|PMID:28802038
Biological Process	GO:0050866	negative regulation of cell activation	Trem2	IDA		Mouse	MGI:MGI:6152919|PMID:29407460
Biological Process	GO:0010887	negative regulation of cholesterol storage	Trem2	IMP		Mouse	MGI:MGI:6448697|PMID:31902528
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	Trem2	IMP		Mouse	MGI:MGI:6391726|PMID:29887864
Biological Process	GO:0070345	negative regulation of fat cell proliferation	Trem2	IMP		Mouse	MGI:MGI:6342648|PMID:31257031
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	Trem2	IMP		Mouse	MGI:MGI:6695683|PMID:29663649
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	Trem2	IMP		Mouse	MGI:MGI:6695683|PMID:29663649
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	Trem2	IMP		Mouse	MGI:MGI:6695683|PMID:29663649
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	Trem2	IMP		Mouse	MGI:MGI:6294162|PMID:28592261
Biological Process	GO:1902227	negative regulation of macrophage colony-stimulating factor signaling pathway	TREM2	IMP		Human	PMID:33097708
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	TREM2	IMP		Human	PMID:32514138
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	Trem2	IMP		Mouse	MGI:MGI:6695864|PMID:31134514
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	Trem2	IMP		Mouse	MGI:MGI:6695687|PMID:31900229
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	Trem2	IDA		Mouse	MGI:MGI:6152919|PMID:29407460
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	TREM2	IMP		Human	PMID:32514138
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	Trem2	IMP		Mouse	MGI:MGI:6391726|PMID:29887864
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	Trem2	IMP		Mouse	MGI:MGI:6695687|PMID:31900229
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	Trem2	IMP		Mouse	MGI:MGI:6695683|PMID:29663649
Biological Process	GO:0010891	negative regulation of sequestering of triglyceride	Trem2	IMP		Mouse	MGI:MGI:6448697|PMID:31902528
Biological Process	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	Trem2	IMP		Mouse	MGI:MGI:6695864|PMID:31134514
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	Trem2	IMP		Mouse	MGI:MGI:6695864|PMID:31134514
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	Trem2	IDA		Mouse	MGI:MGI:6152919|PMID:29407460
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Trem2	IMP		Mouse	MGI:MGI:6294162|PMID:28592261
Biological Process	GO:0150076	neuroinflammatory response	Trem2	IMP		Mouse	MGI:MGI:6193432|PMID:29859094
Biological Process	GO:0030316	osteoclast differentiation	TREM2	IMP		Human	PMID:21841309
Biological Process	GO:0030316	osteoclast differentiation	TREM2	IMP		Human	PMID:12925681
Biological Process	GO:0006911	phagocytosis, engulfment	Trem2	IMP		Mouse	MGI:MGI:5606096|PMID:24990881
Biological Process	GO:0006911	phagocytosis, engulfment	Trem2	IDA		Mouse	PMID:19155473
Biological Process	GO:0006910	phagocytosis, recognition	TREM2	IMP		Human	PMID:32514138
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	TREM2	IMP		Human	PMID:31235932
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	Trem2	IMP		Mouse	MGI:MGI:6313424|PMID:30617257
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	Trem2	IMP		Mouse	MGI:MGI:6378367|PMID:31235932
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	Trem2	IMP		Mouse	MGI:MGI:6254954|PMID:26949937
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	Trem2	IMP		Mouse	MGI:MGI:5906931|PMID:28802038
Biological Process	GO:0002588	positive regulation of antigen processing and presentation of peptide antigen via MHC class II	TREM2	IDA		Human	PMID:11602640
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	Trem2	IMP		Mouse	MGI:MGI:5906931|PMID:28802038
Biological Process	GO:1903082	positive regulation of C-C chemokine receptor CCR7 signaling pathway	TREM2	IDA		Human	PMID:11602640
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	TREM2	IDA		Human	PMID:11602640
Biological Process	GO:1905291	positive regulation of CAMKK-AMPK signaling cascade	Trem2	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:5906931|PMID:28802038
Biological Process	GO:2000350	positive regulation of CD40 signaling pathway	TREM2	IDA		Human	PMID:11602640
Biological Process	GO:0050921	positive regulation of chemotaxis	Trem2	IGI	UniProtKB:P06684:PRO_0000005993|UniProtKB:P10148	Mouse	MGI:MGI:5909167|PMID:28483841
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Trem2	IMP		Mouse	MGI:MGI:6448697|PMID:31902528
Biological Process	GO:0045960	positive regulation of complement activation, classical pathway	Trem2	IMP		Mouse	MGI:MGI:6275756|PMID:30548312
Biological Process	GO:1901076	positive regulation of engulfment of apoptotic cell	TREM2	IMP		Human	PMID:24990881
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	TREM2	IDA		Human	PMID:11602640
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	TREM2	IMP		Human	PMID:27995897
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Trem2	IMP		Mouse	MGI:MGI:6294162|PMID:28592261
Biological Process	GO:1904951	positive regulation of establishment of protein localization	Trem2	IMP		Mouse	MGI:MGI:6313424|PMID:30617257
Biological Process	GO:0010628	positive regulation of gene expression	TREM2	IMP		Human	PMID:32514138
Biological Process	GO:0010628	positive regulation of gene expression	Trem2	IGI	UniProtKB:P10636	Mouse	MGI:MGI:6095556|PMID:29073081
Biological Process	GO:0010983	positive regulation of high-density lipoprotein particle clearance	Trem2	IMP		Mouse	MGI:MGI:6342648|PMID:31257031
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Trem2	IMP		Mouse	MGI:MGI:6294162|PMID:28592261
Biological Process	GO:1901980	positive regulation of inward rectifier potassium channel activity	Trem2	IMP		Mouse	MGI:MGI:6150565|PMID:29518356
Biological Process	GO:0033674	positive regulation of kinase activity	TREM2	IDA		Human	PMID:31902528
Biological Process	GO:1905581	positive regulation of low-density lipoprotein particle clearance	Trem2	IMP		Mouse	MGI:MGI:6342648|PMID:31257031
Biological Process	GO:0034241	positive regulation of macrophage fusion	Trem2	IMP		Mouse	MGI:MGI:6142486|PMID:18957693
Biological Process	GO:1903980	positive regulation of microglial cell activation	TREM2	IMP		Human	PMID:24990881
Biological Process	GO:1903980	positive regulation of microglial cell activation	Trem2	IDA		Mouse	MGI:MGI:6391511|PMID:31370707
Biological Process	GO:1903980	positive regulation of microglial cell activation	Trem2	IMP		Mouse	MGI:MGI:5606096|PMID:24990881
Biological Process	GO:1903980	positive regulation of microglial cell activation	Trem2	IMP		Mouse	MGI:MGI:6313424|PMID:30617257
Biological Process	GO:1903980	positive regulation of microglial cell activation	Trem2	IMP		Mouse	MGI:MGI:6304666|PMID:25631124
Biological Process	GO:1903980	positive regulation of microglial cell activation	Trem2	IMP		Mouse	MGI:MGI:6284411|PMID:29752066
Biological Process	GO:1904141	positive regulation of microglial cell migration	TREM2	IMP		Human	PMID:33097708
Biological Process	GO:1904141	positive regulation of microglial cell migration	Trem2	IMP		Mouse	MGI:MGI:5909167|PMID:28483841
Biological Process	GO:1904141	positive regulation of microglial cell migration	Trem2	IMP		Mouse	MGI:MGI:6313424|PMID:30617257
Biological Process	GO:1904141	positive regulation of microglial cell migration	Trem2	IGI	ComplexPortal:CPX-1120	Mouse	MGI:MGI:6150565|PMID:29518356
Biological Process	GO:1904141	positive regulation of microglial cell migration	Trem2	IGI	UniProtKB:P06684:PRO_0000005993|UniProtKB:P10148	Mouse	MGI:MGI:5909167|PMID:28483841
Biological Process	GO:1904141	positive regulation of microglial cell migration	Trem2	IMP		Mouse	MGI:MGI:6201658|PMID:30232263
Biological Process	GO:0010822	positive regulation of mitochondrion organization	Trem2	IMP		Mouse	MGI:MGI:5906931|PMID:28802038
Biological Process	GO:0150078	positive regulation of neuroinflammatory response	Trem2	IMP		Mouse	MGI:MGI:6304666|PMID:25631124
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Trem2	IMP		Mouse	MGI:MGI:6294162|PMID:28592261
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Trem2	IMP		Mouse	MGI:MGI:6294223|PMID:16418779
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	TREM2	IDA		Human	PMID:32514138
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	TREM2	IDA		Human	PMID:11602640
Biological Process	GO:0050766	positive regulation of phagocytosis	TREM2	IMP		Human	PMID:29518357
Biological Process	GO:0050766	positive regulation of phagocytosis	Trem2	IMP		Mouse	MGI:MGI:6448697|PMID:31902528
Biological Process	GO:0050766	positive regulation of phagocytosis	Trem2	IMP		Mouse	MGI:MGI:6391511|PMID:31370707
Biological Process	GO:0050766	positive regulation of phagocytosis	Trem2	IMP		Mouse	MGI:MGI:6695683|PMID:29663649
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	TREM2	IMP		Human	PMID:32514138
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	TREM2	IMP		Human	PMID:28855300
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	TREM2	IMP		Human	PMID:33097708
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	Trem2	IMP		Mouse	MGI:MGI:6284411|PMID:29752066
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	Trem2	IMP		Mouse	MGI:MGI:6304666|PMID:25631124
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Trem2	IMP		Mouse	MGI:MGI:6458378|PMID:30684126
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	Trem2	IMP		Mouse	MGI:MGI:6150565|PMID:29518356
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	TREM2	IDA		Human	PMID:11602640
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Trem2	IGI	ComplexPortal:CPX-1120	Mouse	MGI:MGI:6150565|PMID:29518356
Biological Process	GO:0050714	positive regulation of protein secretion	TREM2	IMP		Human	PMID:27044754
Biological Process	GO:1905808	positive regulation of synapse pruning	TREM2	IMP		Human	PMID:33097708
Biological Process	GO:0032008	positive regulation of TOR signaling	Trem2	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:5906931|PMID:28802038
Biological Process	GO:0070269	pyroptosis	Trem2	IMP		Mouse	MGI:MGI:6391726|PMID:29887864
Biological Process	GO:1900015	regulation of cytokine production involved in inflammatory response	Trem2	IMP		Mouse	MGI:MGI:6695683|PMID:29663649
Biological Process	GO:0010468	regulation of gene expression	Trem2	IMP		Mouse	MGI:MGI:6275756|PMID:30548312
Biological Process	GO:0010468	regulation of gene expression	Trem2	IGI	ComplexPortal:CPX-1120	Mouse	MGI:MGI:6150565|PMID:29518356
Biological Process	GO:0110089	regulation of hippocampal neuron apoptotic process	Trem2	IMP		Mouse	MGI:MGI:6458378|PMID:30684126
Biological Process	GO:0045088	regulation of innate immune response	Trem2	IMP		Mouse	MGI:MGI:6275756|PMID:30548312
Biological Process	GO:0032675	regulation of interleukin-6 production	Trem2	IGI	ComplexPortal:CPX-1120	Mouse	MGI:MGI:6150565|PMID:29518356
Biological Process	GO:1902531	regulation of intracellular signal transduction	Trem2	IGI	ComplexPortal:CPX-1120	Mouse	MGI:MGI:6150565|PMID:29518356
Biological Process	GO:0019216	regulation of lipid metabolic process	TREM2	IMP		Human	PMID:32514138
Biological Process	GO:0071640	regulation of macrophage inflammatory protein 1 alpha production	Trem2	IGI	ComplexPortal:CPX-1120	Mouse	MGI:MGI:6150565|PMID:29518356
Biological Process	GO:1903376	regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	Trem2	IMP		Mouse	MGI:MGI:6458378|PMID:30684126
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Trem2	IGI	ComplexPortal:CPX-1120	Mouse	MGI:MGI:6150565|PMID:29518356
Biological Process	GO:0120035	regulation of plasma membrane bounded cell projection organization	TREM2	IGI	ComplexPortal:CPX-1120	Human	PMID:29518356
Biological Process	GO:0120035	regulation of plasma membrane bounded cell projection organization	Trem2	IMP		Mouse	MGI:MGI:6201658|PMID:30232263
Biological Process	GO:0120035	regulation of plasma membrane bounded cell projection organization	Trem2	IMP		Mouse	MGI:MGI:5909167|PMID:28483841
Biological Process	GO:0060075	regulation of resting membrane potential	Trem2	IMP		Mouse	MGI:MGI:6150565|PMID:29518356
Biological Process	GO:0034151	regulation of toll-like receptor 6 signaling pathway	Trem2	IMP		Mouse	MGI:MGI:6695864|PMID:31134514
Biological Process	GO:0032006	regulation of TOR signaling	Trem2	IMP		Mouse	MGI:MGI:5906931|PMID:28802038
Biological Process	GO:0045728	respiratory burst after phagocytosis	Trem2	IMP		Mouse	MGI:MGI:6275756|PMID:30548312
Biological Process	GO:0048678	response to axon injury	TREM2	IMP		Human	PMID:31235932
Biological Process	GO:0048678	response to axon injury	TREM2	IMP		Human	PMID:32514138
Biological Process	GO:0048678	response to axon injury	Trem2	IMP		Mouse	MGI:MGI:6378367|PMID:31235932
Biological Process	GO:0048678	response to axon injury	Trem2	IMP		Mouse	MGI:MGI:6448697|PMID:31902528
Biological Process	GO:0002931	response to ischemia	Trem2	IMP		Mouse	MGI:MGI:6294162|PMID:28592261
Biological Process	GO:0035176	social behavior	TREM2	IMP		Human	PMID:29752066
Biological Process	GO:0035176	social behavior	Trem2	IMP		Mouse	MGI:MGI:6284411|PMID:29752066

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern