Source |
Alliance of Genome Resources |
Category | ID | Classification term | Gene | Evidence | Inferred from | Organism | Reference |
---|---|---|---|---|---|---|---|
Molecular Function | GO:0008408 | 3'-5' exonuclease activity | TREX1 | IDA | Human | PMID:10391904 | |
Molecular Function | GO:0008408 | 3'-5' exonuclease activity | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:15254239 |
Molecular Function | GO:0008296 | 3'-5'-DNA exonuclease activity | TREX1 | IDA | Human | PMID:33476576 | |
Molecular Function | GO:0008296 | 3'-5'-DNA exonuclease activity | Trex1 | IDA | Mouse | MGI:MGI:5493219|PMID:11279105 | |
Molecular Function | GO:0032558 | adenyl deoxyribonucleotide binding | Trex1 | IDA | Mouse | PMID:17293595 | |
Molecular Function | GO:0003677 | DNA binding | Trex1 | IDA | Mouse | PMID:20871604 | |
Molecular Function | GO:0008301 | DNA binding, bending | Trex1 | IDA | Mouse | PMID:25848017 | |
Molecular Function | GO:0008311 | double-stranded DNA 3'-5' DNA exonuclease activity | TREX1 | IDA | Human | PMID:33476576 | |
Molecular Function | GO:0003690 | double-stranded DNA binding | Trex1 | IDA | Mouse | PMID:25848017 | |
Molecular Function | GO:0003690 | double-stranded DNA binding | Trex1 | IDA | Mouse | PMID:19158679 | |
Molecular Function | GO:0042802 | identical protein binding | Trex1 | IPI | PR:Q91XB0 | Mouse | PMID:17293595 |
Molecular Function | GO:0000287 | magnesium ion binding | Trex1 | IDA | Mouse | PMID:25848017 | |
Molecular Function | GO:0140678 | molecular function inhibitor activity | TREX1 | IDA | Human | PMID:33476576 | |
Molecular Function | GO:0032405 | MutLalpha complex binding | TREX1 | IDA | Human | PMID:16713580 | |
Molecular Function | GO:0032407 | MutSalpha complex binding | TREX1 | IDA | Human | PMID:16713580 | |
Molecular Function | GO:0005515 | protein binding | Trex1 | IPI | UniProtKB:Q91XB0 | Mouse | MGI:MGI:5493219|PMID:11279105 |
Molecular Function | GO:0005515 | protein binding | Trex1 | IPI | UniProtKB:Q9BQ50 | Mouse | MGI:MGI:5493219|PMID:11279105 |
Molecular Function | GO:0005515 | protein binding | Trex1 | IPI | PR:P35564 | Mouse | PMID:18724932 |
Molecular Function | GO:0042803 | protein homodimerization activity | Trex1 | IPI | UniProtKB:Q91XB0 | Mouse | MGI:MGI:5493219|PMID:11279105 |
Molecular Function | GO:0003697 | single-stranded DNA binding | Trex1 | IDA | Mouse | PMID:17355961 | |
Molecular Function | GO:0003697 | single-stranded DNA binding | Trex1 | IDA | Mouse | PMID:17293595 | |
Molecular Function | GO:0050699 | WW domain binding | Trex1 | IDA | Mouse | PMID:17355961 | |
Cellular Component | GO:0005737 | cytoplasm | Trex1 | IDA | Mouse | PMID:20511593 | |
Cellular Component | GO:0005737 | cytoplasm | Trex1 | IDA | Mouse | PMID:17355961 | |
Cellular Component | GO:0005829 | cytosol | TREX1 | IDA | Human | GO_REF:0000052 | |
Cellular Component | GO:0005829 | cytosol | Trex1 | IDA | Mouse | PMID:28351661 | |
Cellular Component | GO:0005783 | endoplasmic reticulum | Trex1 | IDA | Mouse | PMID:26320659 | |
Cellular Component | GO:0005783 | endoplasmic reticulum | Trex1 | IDA | Mouse | PMID:18724932 | |
Cellular Component | GO:0005789 | endoplasmic reticulum membrane | TREX1 | IDA | Human | PMID:33476576 | |
Cellular Component | GO:0043596 | nuclear replication fork | Trex1 | IDA | Mouse | PMID:18045533 | |
Cellular Component | GO:0005634 | nucleus | Trex1 | IDA | Mouse | PMID:20511593 | |
Cellular Component | GO:0005634 | nucleus | Trex1 | IDA | Mouse | PMID:18045533 | |
Cellular Component | GO:0008250 | oligosaccharyltransferase complex | Trex1 | IDA | Mouse | PMID:26320659 | |
Cellular Component | GO:0032993 | protein-DNA complex | Trex1 | IDA | Mouse | PMID:25848017 | |
Biological Process | GO:0002253 | activation of immune response | Trex1 | IMP | Mouse | PMID:18045533 | |
Biological Process | GO:0002250 | adaptive immune response | Trex1 | IMP | MGI:MGI:5751220 | Mouse | PMID:25848017 |
Biological Process | GO:0043277 | apoptotic cell clearance | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:24218451 |
Biological Process | GO:0003228 | atrial cardiac muscle tissue development | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:15254239 |
Biological Process | GO:0001568 | blood vessel development | Trex1 | IMP | MGI:MGI:5751220 | Mouse | PMID:25848017 |
Biological Process | GO:0035781 | CD86 biosynthetic process | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:24218451 |
Biological Process | GO:0071480 | cellular response to gamma radiation | Trex1 | IMP | Mouse | PMID:18045533 | |
Biological Process | GO:0072711 | cellular response to hydroxyurea | Trex1 | IMP | Mouse | PMID:18045533 | |
Biological Process | GO:0035458 | cellular response to interferon-beta | Trex1 | IDA | Mouse | PMID:19158679 | |
Biological Process | GO:0071310 | cellular response to organic substance | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:28351661 |
Biological Process | GO:0034599 | cellular response to oxidative stress | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:23993650 |
Biological Process | GO:0034614 | cellular response to reactive oxygen species | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:23993650 |
Biological Process | GO:0071357 | cellular response to type I interferon | Trex1 | IMP | Mouse | PMID:28835460 | |
Biological Process | GO:0034644 | cellular response to UV | Trex1 | IDA | Mouse | PMID:20511593 | |
Biological Process | GO:0051607 | defense response to virus | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:23160154 |
Biological Process | GO:0051607 | defense response to virus | Trex1 | IMP | Mouse | PMID:20871604 | |
Biological Process | GO:0008340 | determination of adult lifespan | Trex1 | IGI | MGI:MGI:104663 | Mouse | PMID:28069950 |
Biological Process | GO:0008340 | determination of adult lifespan | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:15254239 |
Biological Process | GO:0008340 | determination of adult lifespan | Trex1 | IGI | MGI:MGI:2442261 | Mouse | PMID:26371324 |
Biological Process | GO:0006308 | DNA catabolic process | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:19923437 |
Biological Process | GO:0006308 | DNA catabolic process | Trex1 | IMP | MGI:MGI:5751220 | Mouse | PMID:25848017 |
Biological Process | GO:0006308 | DNA catabolic process | Trex1 | IDA | Mouse | PMID:20871604 | |
Biological Process | GO:0006308 | DNA catabolic process | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:18724932 |
Biological Process | GO:0006308 | DNA catabolic process | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:23993650 |
Biological Process | GO:0000077 | DNA damage checkpoint signaling | Trex1 | IMP | Mouse | PMID:18045533 | |
Biological Process | GO:0006974 | DNA damage response | Trex1 | IDA | Mouse | PMID:20511593 | |
Biological Process | GO:0032508 | DNA duplex unwinding | Trex1 | IDA | Mouse | PMID:25848017 | |
Biological Process | GO:0006259 | DNA metabolic process | Trex1 | IDA | Mouse | MGI:MGI:5493219|PMID:11279105 | |
Biological Process | GO:0006304 | DNA modification | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:24205360 |
Biological Process | GO:0006260 | DNA replication | Trex1 | IMP | Mouse | PMID:20511593 | |
Biological Process | GO:1904161 | DNA synthesis involved in UV-damage excision repair | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:23993650 |
Biological Process | GO:0045184 | establishment of protein localization | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:23160154 |
Biological Process | GO:0051319 | G2 phase | Trex1 | IMP | Mouse | PMID:18045533 | |
Biological Process | GO:0006091 | generation of precursor metabolites and energy | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:28069950 |
Biological Process | GO:0003007 | heart morphogenesis | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:15254239 |
Biological Process | GO:0003015 | heart process | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:15254239 |
Biological Process | GO:0097281 | immune complex formation | Trex1 | IMP | MGI:MGI:5751220 | Mouse | PMID:25848017 |
Biological Process | GO:0006955 | immune response | Trex1 | IMP | Mouse | PMID:28835460 | |
Biological Process | GO:0002383 | immune response in brain or nervous system | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:24218451 |
Biological Process | GO:0002381 | immunoglobulin production involved in immunoglobulin-mediated immune response | Trex1 | IMP | MGI:MGI:5751220 | Mouse | PMID:25848017 |
Biological Process | GO:0006954 | inflammatory response | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:28351661 |
Biological Process | GO:0006954 | inflammatory response | Trex1 | IMP | MGI:MGI:5751220 | Mouse | PMID:25848017 |
Biological Process | GO:0006954 | inflammatory response | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:15254239 |
Biological Process | GO:0002437 | inflammatory response to antigenic stimulus | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:24218451 |
Biological Process | GO:0045087 | innate immune response | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:23160154 |
Biological Process | GO:0032607 | interferon-alpha production | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:24218451 |
Biological Process | GO:0001822 | kidney development | Trex1 | IMP | MGI:MGI:5751220 | Mouse | PMID:25848017 |
Biological Process | GO:0002320 | lymphoid progenitor cell differentiation | Trex1 | IMP | MGI:MGI:5751220 | Mouse | PMID:25848017 |
Biological Process | GO:0002281 | macrophage activation involved in immune response | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:24218451 |
Biological Process | GO:0031571 | mitotic G1 DNA damage checkpoint signaling | Trex1 | IMP | Mouse | PMID:18045533 | |
Biological Process | GO:0031571 | mitotic G1 DNA damage checkpoint signaling | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:23993650 |
Biological Process | GO:0045824 | negative regulation of innate immune response | TREX1 | IDA | Human | PMID:33476576 | |
Biological Process | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:18724932 |
Biological Process | GO:0002251 | organ or tissue specific immune response | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:24218451 |
Biological Process | GO:0050821 | protein stabilization | Trex1 | IDA | Mouse | PMID:26320659 | |
Biological Process | GO:0050790 | regulation of catalytic activity | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:23160154 |
Biological Process | GO:0031323 | regulation of cellular metabolic process | Trex1 | IGI | MGI:MGI:1929658 | Mouse | PMID:28069950 |
Biological Process | GO:0031323 | regulation of cellular metabolic process | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:28069950 |
Biological Process | GO:0031323 | regulation of cellular metabolic process | Trex1 | IGI | MGI:MGI:1919762 | Mouse | PMID:28069950 |
Biological Process | GO:0043457 | regulation of cellular respiration | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:28069950 |
Biological Process | GO:0019217 | regulation of fatty acid metabolic process | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:28069950 |
Biological Process | GO:0010468 | regulation of gene expression | Trex1 | IGI | MGI:MGI:1859212 | Mouse | PMID:23160154 |
Biological Process | GO:0010468 | regulation of gene expression | Trex1 | IGI | MGI:MGI:1929658 | Mouse | PMID:23160154 |
Biological Process | GO:0010468 | regulation of gene expression | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:23160154 |
Biological Process | GO:0010468 | regulation of gene expression | Trex1 | IGI | MGI:MGI:1859179 | Mouse | PMID:23160154 |
Biological Process | GO:0010468 | regulation of gene expression | Trex1 | IGI | MGI:MGI:1919762 | Mouse | PMID:23160154 |
Biological Process | GO:0006110 | regulation of glycolytic process | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:28069950 |
Biological Process | GO:0002637 | regulation of immunoglobulin production | Trex1 | IMP | Mouse | PMID:26320659 | |
Biological Process | GO:0002637 | regulation of immunoglobulin production | Trex1 | IGI | MGI:MGI:2442261 | Mouse | PMID:26371324 |
Biological Process | GO:0050727 | regulation of inflammatory response | Trex1 | IGI | MGI:MGI:1919762 | Mouse | PMID:28069950 |
Biological Process | GO:0050727 | regulation of inflammatory response | Trex1 | IGI | MGI:MGI:1859179 | Mouse | PMID:28069950 |
Biological Process | GO:0045088 | regulation of innate immune response | Trex1 | IMP | Mouse | PMID:26320659 | |
Biological Process | GO:0045088 | regulation of innate immune response | Trex1 | IMP | Mouse | PMID:20871604 | |
Biological Process | GO:0046890 | regulation of lipid biosynthetic process | Trex1 | IGI | MGI:MGI:104663 | Mouse | PMID:28069950 |
Biological Process | GO:1905671 | regulation of lysosome organization | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:23160154 |
Biological Process | GO:0061635 | regulation of protein complex stability | Trex1 | IMP | Mouse | PMID:26320659 | |
Biological Process | GO:0050863 | regulation of T cell activation | Trex1 | IGI | MGI:MGI:2442261 | Mouse | PMID:26371324 |
Biological Process | GO:0032680 | regulation of tumor necrosis factor production | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:24218451 |
Biological Process | GO:0032479 | regulation of type I interferon production | Trex1 | IGI | MGI:MGI:2442261 | Mouse | PMID:26371324 |
Biological Process | GO:0032479 | regulation of type I interferon production | Trex1 | IMP | Mouse | PMID:20871604 | |
Biological Process | GO:0032479 | regulation of type I interferon production | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:24154727 |
Biological Process | GO:0009411 | response to UV | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:28351661 |
Biological Process | GO:0032197 | retrotransposition | Trex1 | IMP | Mouse | PMID:28835460 | |
Biological Process | GO:0002457 | T cell antigen processing and presentation | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:24218451 |
Biological Process | GO:0060337 | type I interferon-mediated signaling pathway | Trex1 | IMP | MGI:MGI:3052754 | Mouse | PMID:28351661 |
EXP Inferred from experiment |
IDA Inferred from direct assay |
IEP Inferred from expression pattern |
IGI Inferred from genetic interaction |
IMP Inferred from mutant phenotype |
IPI Inferred from physical interaction |
HTP Inferred from High Throughput Experiment |
HDA Inferred from High Throughput Direct Assay |
HMP Inferred from High Throughput Mutant Phenotype |
HGI Inferred from High Throughput Genetic Interaction |
HEP Inferred from High Throughput Expression Pattern |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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