Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TREX1
  • Mouse genes Trex1
  • Rat genes Trex1
  • Zfish genes plex9.1,plex9.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trex1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008408	3'-5' exonuclease activity	TREX1	IDA		Human	PMID:10391904
Molecular Function	GO:0008408	3'-5' exonuclease activity	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:15254239
Molecular Function	GO:0008296	3'-5'-DNA exonuclease activity	TREX1	IDA		Human	PMID:33476576
Molecular Function	GO:0008296	3'-5'-DNA exonuclease activity	Trex1	IDA		Mouse	MGI:MGI:5493219|PMID:11279105
Molecular Function	GO:0032558	adenyl deoxyribonucleotide binding	Trex1	IDA		Mouse	PMID:17293595
Molecular Function	GO:0003677	DNA binding	Trex1	IDA		Mouse	PMID:20871604
Molecular Function	GO:0008301	DNA binding, bending	Trex1	IDA		Mouse	PMID:25848017
Molecular Function	GO:0008311	double-stranded DNA 3'-5' DNA exonuclease activity	TREX1	IDA		Human	PMID:33476576
Molecular Function	GO:0003690	double-stranded DNA binding	Trex1	IDA		Mouse	PMID:25848017
Molecular Function	GO:0003690	double-stranded DNA binding	Trex1	IDA		Mouse	PMID:19158679
Molecular Function	GO:0042802	identical protein binding	Trex1	IPI	PR:Q91XB0	Mouse	PMID:17293595
Molecular Function	GO:0000287	magnesium ion binding	Trex1	IDA		Mouse	PMID:25848017
Molecular Function	GO:0140678	molecular function inhibitor activity	TREX1	IDA		Human	PMID:33476576
Molecular Function	GO:0032405	MutLalpha complex binding	TREX1	IDA		Human	PMID:16713580
Molecular Function	GO:0032407	MutSalpha complex binding	TREX1	IDA		Human	PMID:16713580
Molecular Function	GO:0005515	protein binding	Trex1	IPI	UniProtKB:Q91XB0	Mouse	MGI:MGI:5493219|PMID:11279105
Molecular Function	GO:0005515	protein binding	Trex1	IPI	UniProtKB:Q9BQ50	Mouse	MGI:MGI:5493219|PMID:11279105
Molecular Function	GO:0005515	protein binding	Trex1	IPI	PR:P35564	Mouse	PMID:18724932
Molecular Function	GO:0042803	protein homodimerization activity	Trex1	IPI	UniProtKB:Q91XB0	Mouse	MGI:MGI:5493219|PMID:11279105
Molecular Function	GO:0003697	single-stranded DNA binding	Trex1	IDA		Mouse	PMID:17355961
Molecular Function	GO:0003697	single-stranded DNA binding	Trex1	IDA		Mouse	PMID:17293595
Molecular Function	GO:0050699	WW domain binding	Trex1	IDA		Mouse	PMID:17355961
Cellular Component	GO:0005737	cytoplasm	Trex1	IDA		Mouse	PMID:20511593
Cellular Component	GO:0005737	cytoplasm	Trex1	IDA		Mouse	PMID:17355961
Cellular Component	GO:0005829	cytosol	TREX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Trex1	IDA		Mouse	PMID:28351661
Cellular Component	GO:0005783	endoplasmic reticulum	Trex1	IDA		Mouse	PMID:26320659
Cellular Component	GO:0005783	endoplasmic reticulum	Trex1	IDA		Mouse	PMID:18724932
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TREX1	IDA		Human	PMID:33476576
Cellular Component	GO:0043596	nuclear replication fork	Trex1	IDA		Mouse	PMID:18045533
Cellular Component	GO:0005634	nucleus	Trex1	IDA		Mouse	PMID:20511593
Cellular Component	GO:0005634	nucleus	Trex1	IDA		Mouse	PMID:18045533
Cellular Component	GO:0008250	oligosaccharyltransferase complex	Trex1	IDA		Mouse	PMID:26320659
Cellular Component	GO:0032993	protein-DNA complex	Trex1	IDA		Mouse	PMID:25848017
Biological Process	GO:0002253	activation of immune response	Trex1	IMP		Mouse	PMID:18045533
Biological Process	GO:0002250	adaptive immune response	Trex1	IMP	MGI:MGI:5751220	Mouse	PMID:25848017
Biological Process	GO:0043277	apoptotic cell clearance	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:24218451
Biological Process	GO:0003228	atrial cardiac muscle tissue development	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:15254239
Biological Process	GO:0001568	blood vessel development	Trex1	IMP	MGI:MGI:5751220	Mouse	PMID:25848017
Biological Process	GO:0035781	CD86 biosynthetic process	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:24218451
Biological Process	GO:0071480	cellular response to gamma radiation	Trex1	IMP		Mouse	PMID:18045533
Biological Process	GO:0072711	cellular response to hydroxyurea	Trex1	IMP		Mouse	PMID:18045533
Biological Process	GO:0035458	cellular response to interferon-beta	Trex1	IDA		Mouse	PMID:19158679
Biological Process	GO:0071310	cellular response to organic substance	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:28351661
Biological Process	GO:0034599	cellular response to oxidative stress	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:23993650
Biological Process	GO:0034614	cellular response to reactive oxygen species	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:23993650
Biological Process	GO:0071357	cellular response to type I interferon	Trex1	IMP		Mouse	PMID:28835460
Biological Process	GO:0034644	cellular response to UV	Trex1	IDA		Mouse	PMID:20511593
Biological Process	GO:0051607	defense response to virus	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:23160154
Biological Process	GO:0051607	defense response to virus	Trex1	IMP		Mouse	PMID:20871604
Biological Process	GO:0008340	determination of adult lifespan	Trex1	IGI	MGI:MGI:104663	Mouse	PMID:28069950
Biological Process	GO:0008340	determination of adult lifespan	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:15254239
Biological Process	GO:0008340	determination of adult lifespan	Trex1	IGI	MGI:MGI:2442261	Mouse	PMID:26371324
Biological Process	GO:0006308	DNA catabolic process	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:19923437
Biological Process	GO:0006308	DNA catabolic process	Trex1	IMP	MGI:MGI:5751220	Mouse	PMID:25848017
Biological Process	GO:0006308	DNA catabolic process	Trex1	IDA		Mouse	PMID:20871604
Biological Process	GO:0006308	DNA catabolic process	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:18724932
Biological Process	GO:0006308	DNA catabolic process	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:23993650
Biological Process	GO:0000077	DNA damage checkpoint signaling	Trex1	IMP		Mouse	PMID:18045533
Biological Process	GO:0006974	DNA damage response	Trex1	IDA		Mouse	PMID:20511593
Biological Process	GO:0032508	DNA duplex unwinding	Trex1	IDA		Mouse	PMID:25848017
Biological Process	GO:0006259	DNA metabolic process	Trex1	IDA		Mouse	MGI:MGI:5493219|PMID:11279105
Biological Process	GO:0006304	DNA modification	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:24205360
Biological Process	GO:0006260	DNA replication	Trex1	IMP		Mouse	PMID:20511593
Biological Process	GO:1904161	DNA synthesis involved in UV-damage excision repair	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:23993650
Biological Process	GO:0045184	establishment of protein localization	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:23160154
Biological Process	GO:0051319	G2 phase	Trex1	IMP		Mouse	PMID:18045533
Biological Process	GO:0006091	generation of precursor metabolites and energy	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:28069950
Biological Process	GO:0003007	heart morphogenesis	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:15254239
Biological Process	GO:0003015	heart process	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:15254239
Biological Process	GO:0097281	immune complex formation	Trex1	IMP	MGI:MGI:5751220	Mouse	PMID:25848017
Biological Process	GO:0006955	immune response	Trex1	IMP		Mouse	PMID:28835460
Biological Process	GO:0002383	immune response in brain or nervous system	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:24218451
Biological Process	GO:0002381	immunoglobulin production involved in immunoglobulin-mediated immune response	Trex1	IMP	MGI:MGI:5751220	Mouse	PMID:25848017
Biological Process	GO:0006954	inflammatory response	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:28351661
Biological Process	GO:0006954	inflammatory response	Trex1	IMP	MGI:MGI:5751220	Mouse	PMID:25848017
Biological Process	GO:0006954	inflammatory response	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:15254239
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:24218451
Biological Process	GO:0045087	innate immune response	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:23160154
Biological Process	GO:0032607	interferon-alpha production	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:24218451
Biological Process	GO:0001822	kidney development	Trex1	IMP	MGI:MGI:5751220	Mouse	PMID:25848017
Biological Process	GO:0002320	lymphoid progenitor cell differentiation	Trex1	IMP	MGI:MGI:5751220	Mouse	PMID:25848017
Biological Process	GO:0002281	macrophage activation involved in immune response	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:24218451
Biological Process	GO:0031571	mitotic G1 DNA damage checkpoint signaling	Trex1	IMP		Mouse	PMID:18045533
Biological Process	GO:0031571	mitotic G1 DNA damage checkpoint signaling	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:23993650
Biological Process	GO:0045824	negative regulation of innate immune response	TREX1	IDA		Human	PMID:33476576
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:18724932
Biological Process	GO:0002251	organ or tissue specific immune response	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:24218451
Biological Process	GO:0050821	protein stabilization	Trex1	IDA		Mouse	PMID:26320659
Biological Process	GO:0050790	regulation of catalytic activity	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:23160154
Biological Process	GO:0031323	regulation of cellular metabolic process	Trex1	IGI	MGI:MGI:1929658	Mouse	PMID:28069950
Biological Process	GO:0031323	regulation of cellular metabolic process	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:28069950
Biological Process	GO:0031323	regulation of cellular metabolic process	Trex1	IGI	MGI:MGI:1919762	Mouse	PMID:28069950
Biological Process	GO:0043457	regulation of cellular respiration	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:28069950
Biological Process	GO:0019217	regulation of fatty acid metabolic process	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:28069950
Biological Process	GO:0010468	regulation of gene expression	Trex1	IGI	MGI:MGI:1859212	Mouse	PMID:23160154
Biological Process	GO:0010468	regulation of gene expression	Trex1	IGI	MGI:MGI:1929658	Mouse	PMID:23160154
Biological Process	GO:0010468	regulation of gene expression	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:23160154
Biological Process	GO:0010468	regulation of gene expression	Trex1	IGI	MGI:MGI:1859179	Mouse	PMID:23160154
Biological Process	GO:0010468	regulation of gene expression	Trex1	IGI	MGI:MGI:1919762	Mouse	PMID:23160154
Biological Process	GO:0006110	regulation of glycolytic process	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:28069950
Biological Process	GO:0002637	regulation of immunoglobulin production	Trex1	IMP		Mouse	PMID:26320659
Biological Process	GO:0002637	regulation of immunoglobulin production	Trex1	IGI	MGI:MGI:2442261	Mouse	PMID:26371324
Biological Process	GO:0050727	regulation of inflammatory response	Trex1	IGI	MGI:MGI:1919762	Mouse	PMID:28069950
Biological Process	GO:0050727	regulation of inflammatory response	Trex1	IGI	MGI:MGI:1859179	Mouse	PMID:28069950
Biological Process	GO:0045088	regulation of innate immune response	Trex1	IMP		Mouse	PMID:26320659
Biological Process	GO:0045088	regulation of innate immune response	Trex1	IMP		Mouse	PMID:20871604
Biological Process	GO:0046890	regulation of lipid biosynthetic process	Trex1	IGI	MGI:MGI:104663	Mouse	PMID:28069950
Biological Process	GO:1905671	regulation of lysosome organization	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:23160154
Biological Process	GO:0061635	regulation of protein complex stability	Trex1	IMP		Mouse	PMID:26320659
Biological Process	GO:0050863	regulation of T cell activation	Trex1	IGI	MGI:MGI:2442261	Mouse	PMID:26371324
Biological Process	GO:0032680	regulation of tumor necrosis factor production	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:24218451
Biological Process	GO:0032479	regulation of type I interferon production	Trex1	IGI	MGI:MGI:2442261	Mouse	PMID:26371324
Biological Process	GO:0032479	regulation of type I interferon production	Trex1	IMP		Mouse	PMID:20871604
Biological Process	GO:0032479	regulation of type I interferon production	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:24154727
Biological Process	GO:0009411	response to UV	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:28351661
Biological Process	GO:0032197	retrotransposition	Trex1	IMP		Mouse	PMID:28835460
Biological Process	GO:0002457	T cell antigen processing and presentation	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:24218451
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	Trex1	IMP	MGI:MGI:3052754	Mouse	PMID:28351661

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern