Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TF
  • Mouse genes Trf
  • Rat genes Tf
  • Zfish genes tfa
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008199	ferric iron binding	Tf	IDA		Rat	PMID:17373738|RGD:1601530
Molecular Function	GO:0008198	ferrous iron binding	TF	IDA		Human	PMID:18353247
Molecular Function	GO:0034986	iron chaperone activity	TF	IDA		Human	PMID:18353247
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:P02786	Human	PMID:14691533
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:P49281	Human	PMID:15880641
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q30201	Human	PMID:15880641
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:P02786	Human	PMID:16271884
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:P02786	Human	PMID:16354665
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:P01350	Human	PMID:19664057
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:P02786	Human	PMID:20404192
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:P02786	Human	PMID:21788477
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q9K0U9	Human	PMID:22327295
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q9K0V0	Human	PMID:22327295
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q09057	Human	PMID:22343719
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:P02786	Human	PMID:29302006
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:A8MZ59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:O00501	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:O15173	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:O15529	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:O43278-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:O43315	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:P08034	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q3KNW5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q4KMG9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q7Z7G2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q8N9I0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q8NBJ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q8TED1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q96KR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q96TC7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q99523	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q9BXS9-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q9GZR5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TF	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Trf	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:1990459	transferrin receptor binding	TF	IPI	UniProtKB:P02786	Human	PMID:18353247
Molecular Function	GO:1990459	transferrin receptor binding	TF	IPI	UniProtKB:Q9UP52	Human	PMID:18353247
Molecular Function	GO:1990459	transferrin receptor binding	TF	IPI	UniProtKB:P02786	Human	PMID:29388418
Molecular Function	GO:1990459	transferrin receptor binding	TF	IPI	UniProtKB:Q9UP52	Human	PMID:29388418
Molecular Function	GO:1990459	transferrin receptor binding	TF	IPI	UniProtKB:P02786	Human	PMID:9546397
Cellular Component	GO:0016324	apical plasma membrane	TF	IDA		Human	PMID:11208127
Cellular Component	GO:0045178	basal part of cell	TF	IDA		Human	PMID:15880641
Cellular Component	GO:0009925	basal plasma membrane	TF	IDA		Human	PMID:15880641
Cellular Component	GO:0005604	basement membrane	Tf	IDA		Rat	PMID:1723977|RGD:1625719
Cellular Component	GO:0072562	blood microparticle	TF	HDA		Human	PMID:22516433
Cellular Component	GO:0009986	cell surface	TF	IDA		Human	PMID:16195351
Cellular Component	GO:0051286	cell tip	Tf	IDA		Rat	PMID:17373738|RGD:1601530
Cellular Component	GO:0005905	clathrin-coated pit	TF	IDA		Human	PMID:12857860
Cellular Component	GO:0005905	clathrin-coated pit	Trf	IDA		Mouse	PMID:20427320
Cellular Component	GO:0031410	cytoplasmic vesicle	TF	IDA		Human	PMID:12857860
Cellular Component	GO:0030425	dendrite	Tf	IDA		Rat	PMID:26109571|RGD:152995513
Cellular Component	GO:0005769	early endosome	TF	IDA		Human	PMID:15880641
Cellular Component	GO:0005769	early endosome	Trf	IDA		Mouse	PMID:23416069
Cellular Component	GO:0005769	early endosome	Trf	IDA		Mouse	PMID:24035762
Cellular Component	GO:0030139	endocytic vesicle	TF	IDA		Human	PMID:15229288
Cellular Component	GO:0030139	endocytic vesicle	TF	IDA		Human	PMID:15292400
Cellular Component	GO:0030139	endocytic vesicle	Trf	IDA		Mouse	PMID:12121420
Cellular Component	GO:0005768	endosome	Trf	IDA		Mouse	PMID:18477453
Cellular Component	GO:0005768	endosome	Trf	IDA		Mouse	PMID:23416069
Cellular Component	GO:0005768	endosome	Trf	IDA		Mouse	PMID:15247266
Cellular Component	GO:0005768	endosome	Trf	IDA		Mouse	PMID:23303939
Cellular Component	GO:0005768	endosome	Trf	IDA		Mouse	PMID:16227996
Cellular Component	GO:0070062	extracellular exosome	TF	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	TF	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	TF	IGI	UniProtKB:Q9UP52	Human	PMID:18353247
Cellular Component	GO:0005576	extracellular region	TF	IDA		Human	PMID:9990067
Cellular Component	GO:0005615	extracellular space	TF	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	TF	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	TF	HDA		Human	PMID:23580065
Cellular Component	GO:0005615	extracellular space	Tf	IDA		Rat	PMID:17350134|RGD:1601515
Cellular Component	GO:1990712	HFE-transferrin receptor complex	TF	IDA		Human	PMID:9546397
Cellular Component	GO:0005770	late endosome	TF	IDA		Human	PMID:15880641
Cellular Component	GO:0016020	membrane	Trf	IMP		Mouse	MGI:MGI:4420830|PMID:20080761
Cellular Component	GO:0048471	perinuclear region of cytoplasm	TF	IDA		Human	PMID:15880641
Cellular Component	GO:0048471	perinuclear region of cytoplasm	TF	IDA		Human	PMID:20202662
Cellular Component	GO:0055037	recycling endosome	TF	IDA		Human	PMID:15880641
Cellular Component	GO:0055037	recycling endosome	Trf	IDA		Mouse	PMID:11739192
Cellular Component	GO:0055037	recycling endosome	Trf	IDA		Mouse	PMID:19061864
Cellular Component	GO:0031982	vesicle	TF	IDA		Human	PMID:18353773
Biological Process	GO:0007015	actin filament organization	Trf	IDA		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0006953	acute-phase response	Tf	IEP		Rat	PMID:17417667|RGD:1601529
Biological Process	GO:0071320	cellular response to cAMP	Tf	IEP		Rat	PMID:15831523|RGD:8553441
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Tf	IEP		Rat	PMID:15831523|RGD:8553441
Biological Process	GO:0071281	cellular response to iron ion	TF	IGI	UniProtKB:Q07891,UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Trf	IDA		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0042541	hemoglobin biosynthetic process	tfa	IMP	ZFIN:ZDB-MRPHLNO-090609-8	Zfish	PMID:19047682
Biological Process	GO:0042541	hemoglobin biosynthetic process	tfa	IMP	ZFIN:ZDB-MRPHLNO-090609-8,ZFIN:ZDB-MRPHLNO-090609-9	Zfish	PMID:19047682
Biological Process	GO:0042541	hemoglobin biosynthetic process	tfa	IMP	ZFIN:ZDB-MRPHLNO-090609-9	Zfish	PMID:19047682
Biological Process	GO:0006879	intracellular iron ion homeostasis	TF	IGI	UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0006826	iron ion transport	Trf	IMP	MGI:MGI:1856905	Mouse	PMID:11230685
Biological Process	GO:0006826	iron ion transport	Tf	IDA		Rat	PMID:17373738|RGD:1601530
Biological Process	GO:0006826	iron ion transport	tfa	IMP	ZFIN:ZDB-MRPHLNO-090609-8	Zfish	PMID:19047682
Biological Process	GO:0030316	osteoclast differentiation	Trf	IDA		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0045780	positive regulation of bone resorption	Trf	IDA		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:2000147	positive regulation of cell motility	Trf	IDA		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Trf	IDA		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0031643	positive regulation of myelination	Tf	IDA		Rat	PMID:16480980|RGD:1601540
Biological Process	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	Tf	IDA		Rat	PMID:23368675|RGD:7244376
Biological Process	GO:0042327	positive regulation of phosphorylation	Trf	IDA		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	TF	IDA		Human	PMID:12704209
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	TF	IGI	UniProtKB:Q07891,UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0034756	regulation of iron ion transport	TF	IGI	UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0009617	response to bacterium	Trf	IEP		Mouse	PMID:23012479
Biological Process	GO:0009617	response to bacterium	tfa	IDA		Zfish	PMID:17804254
Biological Process	GO:0001666	response to hypoxia	Tf	IEP		Rat	PMID:16479386|RGD:1601542
Biological Process	GO:0010288	response to lead ion	Tf	IEP		Rat	PMID:23007736|RGD:7244378
Biological Process	GO:0014070	response to organic cyclic compound	Tf	IEP		Rat	PMID:16519141|RGD:1601539
Biological Process	GO:0001895	retina homeostasis	TF	HEP		Human	PMID:23580065
Biological Process	GO:0060395	SMAD protein signal transduction	Trf	IDA		Mouse	PMID:9420335

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern