Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRIM21
  • Mouse genes Trim21
  • Rat genes Trim21
  • Zfish genes btr04,btr20,btr21,btr25
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trim21

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TRIM21	IPI	UniProtKB:P19474	Human	PMID:17156811
Molecular Function	GO:0042802	identical protein binding	TRIM21	IPI	UniProtKB:P19474	Human	PMID:22493164
Molecular Function	GO:0042802	identical protein binding	TRIM21	IPI	UniProtKB:P19474	Human	PMID:22829933
Molecular Function	GO:0042802	identical protein binding	TRIM21	IPI	UniProtKB:P19474	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	TRIM21	IPI	UniProtKB:P19474	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q13107-1	Human	PMID:11461834
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:P63208	Human	PMID:16880511
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q13309	Human	PMID:16880511
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q13616	Human	PMID:16880511
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q9UKB1	Human	PMID:16880511
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:O14920	Human	PMID:19675099
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q9HCM9	Human	PMID:22493164
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q13588	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q7KZS0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q99757	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q9HCM9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q9Y4E8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:O15553	Human	PMID:26347139
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:O75385|UniProtKB:O95166|UniProtKB:Q13501|UniProtKB:Q14457|UniProtKB:Q14653	Human	PMID:26347139
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:P14240	Human	PMID:29261807
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:P17813	Human	PMID:31540324
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:O00257-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:O15296	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:O75382	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q05516	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q08426	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q13588	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q6GPH4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q7KZS0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q86VF2-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q8IYI6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q8IZW8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q96IK5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q99757	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q9BW85	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q9HCM9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q9NPF5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q9NUJ3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q9NXE8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q9Y2B5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q9Y613	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:O60260-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:P09936	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q14203-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:P11021	Human	PMID:8666824
Molecular Function	GO:0005515	protein binding	TRIM21	IPI	UniProtKB:P27797	Human	PMID:8666824
Molecular Function	GO:0005515	protein binding	Trim21	IPI	UniProtKB:Q91VN6	Mouse	MGI:MGI:5465368|PMID:23222971
Molecular Function	GO:0005515	protein binding	Trim21	IPI	UniProtKB:O41974	Mouse	MGI:MGI:5787727|PMID:26581985
Molecular Function	GO:0003713	transcription coactivator activity	TRIM21	IDA		Human	PMID:23077300
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TRIM21	IDA		Human	PMID:26342464
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TRIM21	IDA		Human	PMID:36359729
Molecular Function	GO:0061630	ubiquitin protein ligase activity	btr20	IDA		Zfish	PMID:25542153
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TRIM21	IDA		Human	PMID:16297862
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TRIM21	IDA		Human	PMID:16472766
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TRIM21	IDA		Human	PMID:16880511
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TRIM21	IDA		Human	PMID:18845142
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TRIM21	IDA		Human	PMID:19675099
Cellular Component	GO:0005737	cytoplasm	TRIM21	IDA		Human	PMID:16316627
Cellular Component	GO:0005737	cytoplasm	TRIM21	IDA		Human	PMID:18845142
Cellular Component	GO:0005737	cytoplasm	Trim21	IDA		Mouse	PMID:11331580
Cellular Component	GO:0005737	cytoplasm	btr20	IDA		Zfish	PMID:25542153
Cellular Component	GO:0005654	nucleoplasm	TRIM21	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TRIM21	IDA		Human	PMID:18845142
Biological Process	GO:0045087	innate immune response	TRIM21	IDA		Human	PMID:18248090
Biological Process	GO:0045824	negative regulation of innate immune response	TRIM21	IDA		Human	PMID:26342464
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	TRIM21	IDA		Human	PMID:19675099
Biological Process	GO:0090086	negative regulation of protein deubiquitination	TRIM21	IMP		Human	PMID:16472766
Biological Process	GO:0032897	negative regulation of viral transcription	TRIM21	IDA		Human	PMID:18248090
Biological Process	GO:0010508	positive regulation of autophagy	TRIM21	IMP		Human	PMID:26347139
Biological Process	GO:0045787	positive regulation of cell cycle	TRIM21	IMP		Human	PMID:16880511
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	TRIM21	IDA		Human	PMID:23077300
Biological Process	GO:0032092	positive regulation of protein binding	TRIM21	IMP		Human	PMID:26342464
Biological Process	GO:0046598	positive regulation of viral entry into host cell	Trim21	IDA		Mouse	MGI:MGI:5545996|PMID:18248090
Biological Process	GO:0010498	proteasomal protein catabolic process	TRIM21	IDA		Human	PMID:36359729
Biological Process	GO:0051865	protein autoubiquitination	TRIM21	IDA		Human	PMID:16880511
Biological Process	GO:0031648	protein destabilization	TRIM21	IMP		Human	PMID:16880511
Biological Process	GO:0070936	protein K48-linked ubiquitination	TRIM21	IDA		Human	PMID:36359729
Biological Process	GO:0070534	protein K63-linked ubiquitination	TRIM21	IMP		Human	PMID:26342464
Biological Process	GO:0006513	protein monoubiquitination	TRIM21	IDA		Human	PMID:16297862
Biological Process	GO:0006513	protein monoubiquitination	TRIM21	IDA		Human	PMID:19675099
Biological Process	GO:0000209	protein polyubiquitination	TRIM21	IDA		Human	PMID:16297862
Biological Process	GO:0016567	protein ubiquitination	TRIM21	IDA		Human	PMID:16472766
Biological Process	GO:0016567	protein ubiquitination	TRIM21	IDA		Human	PMID:16880511
Biological Process	GO:0016567	protein ubiquitination	TRIM21	IDA		Human	PMID:18845142
Biological Process	GO:0034341	response to type II interferon	TRIM21	IDA		Human	PMID:26347139
Biological Process	GO:0044790	suppression of viral release by host	TRIM21	IDA		Human	PMID:18248090

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern