Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRIM25
  • Mouse genes Trim25
  • Rat genes Trim25
  • Zfish genes trim25
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trim25

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	TRIM25	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:P03496	Human	PMID:19454348
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:O95786	Human	PMID:20818395
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:Q15911	Human	PMID:22452784
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:O95786	Human	PMID:24478431
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:K9N4V7	Human	PMID:32295922
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:P0DTC9	Human	PMID:34029587
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:P0DTC9	Human	PMID:34110264
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:O95786	Human	PMID:34452305
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:P0DTC9	Human	PMID:34452305
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:O95786	Human	PMID:34471099
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:P0DTC9	Human	PMID:34471099
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:P0DTC9	Human	PMID:34578187
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:Q13283	Human	PMID:34799561
Molecular Function	GO:0005515	protein binding	TRIM25	IPI	UniProtKB:O95786	Human	PMID:35075101
Molecular Function	GO:0005515	protein binding	Trim25	IPI	UniProtKB:O88700|UniProtKB:Q9CWE6|UniProtKB:Q9CWU5	Mouse	MGI:MGI:6467697|PMID:29125140
Molecular Function	GO:0039552	RIG-I binding	TRIM25	IPI	UniProtKB:O95786	Human	PMID:23950712
Molecular Function	GO:0003723	RNA binding	TRIM25	HDA		Human	PMID:22658674
Molecular Function	GO:0003713	transcription coactivator activity	TRIM25	IDA		Human	PMID:23077300
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TRIM25	IDA		Human	PMID:16352599
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TRIM25	IMP		Human	PMID:24810856
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TRIM25	EXP		Human	PMID:17392790
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TRIM25	EXP		Human	PMID:19017631
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TRIM25	EXP		Human	PMID:19484123
Cellular Component	GO:0005737	cytoplasm	TRIM25	IDA		Human	PMID:23950712
Cellular Component	GO:0005737	cytoplasm	Trim25	IDA		Mouse	PMID:11331580
Cellular Component	GO:0010494	cytoplasmic stress granule	TRIM25	IDA		Human	PMID:23950712
Cellular Component	GO:0005829	cytosol	TRIM25	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	TRIM25	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TRIM25	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Trim25	IDA		Mouse	MGI:MGI:6467697|PMID:29125140
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Trim25	IEP		Mouse	PMID:20439489
Biological Process	GO:0002753	cytosolic pattern recognition receptor signaling pathway	TRIM25	IDA		Human	PMID:17392790
Biological Process	GO:0045087	innate immune response	TRIM25	IDA		Human	PMID:18248090
Biological Process	GO:0045087	innate immune response	Trim25	IDA		Mouse	MGI:MGI:5545996|PMID:18248090
Biological Process	GO:0046597	negative regulation of viral entry into host cell	Trim25	IDA		Mouse	MGI:MGI:5545996|PMID:18248090
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	TRIM25	IMP		Human	PMID:23077300
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TRIM25	IDA		Human	PMID:23077300
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TRIM25	IMP		Human	PMID:23077300
Biological Process	GO:0006513	protein monoubiquitination	TRIM25	IMP		Human	PMID:24810856
Biological Process	GO:0032880	regulation of protein localization	Trim25	IMP		Mouse	MGI:MGI:6467697|PMID:29125140
Biological Process	GO:0039535	regulation of RIG-I signaling pathway	trim25	IMP	ZFIN:ZDB-MRPHLNO-150320-1	Zfish	PMID:25265425
Biological Process	GO:0046596	regulation of viral entry into host cell	TRIM25	IDA		Human	PMID:18248090
Biological Process	GO:0043627	response to estrogen	TRIM25	IDA		Human	PMID:22452784
Biological Process	GO:0043627	response to estrogen	Trim25	IEP		Rat	PMID:10425199|RGD:1300518
Biological Process	GO:0033280	response to vitamin D	Trim25	IEP		Rat	PMID:10425199|RGD:1300518
Biological Process	GO:0044790	suppression of viral release by host	Trim25	IDA		Mouse	MGI:MGI:5545996|PMID:18248090
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	TRIM25	IMP		Human	PMID:24810856
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	TRIM25	IMP		Human	PMID:22452784
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	TRIM25	IMP		Human	PMID:24810856
Biological Process	GO:0019076	viral release from host cell	TRIM25	IMP		Human	PMID:18248090

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern